2018 American Transplant Congress
Many Highly Sensitized Candidates Still Waiting for Transplant Despite the Kidney Allocation System Change: Making the Case for Incompatible Transplantation
Introduction: The rate of kidney transplantation in highly sensitized individuals has increased since the kidney allocation system (KAS) change, but it remains unclear who has…2018 American Transplant Congress
Elevated Skin Specific Non-HLA Antibodies Correlate with Acute Rejection Episodes in Clinical VCA
Introduction: Vascularized composite allotransplantation (VCA) is unique by presence of the skin in the allografts. Due to the high immunogenicity of skin and the presence…2018 American Transplant Congress
Immune Profiling in Highly Sensitized Kidney Transplant Recipients
Surgery, McGill University, Montreal, Canada.
Introduction: Highly sensitized patients (HSP) express foreign HLA antibodies and have poor graft survival due to higher incidences of graft rejection as compared to non-sensitized…2018 American Transplant Congress
Memory T Cell Dysfunction after Pregnancy Alloimmunization Prolongs Transplant Survival
Background Pregnancy alloimmunization can preclude donor compatibility and may diminish transplant lifespan. While these consequences may be attributed to immunologic memory responses that endanger an…2018 American Transplant Congress
Two Similar Risk Models Identify Different Patients for Graft Loss: Implications for Clinical Trials in DSA+ Kidney Transplant Recipients
William J von Liebig Transplant Center, Mayo Clinic, Rochester.
Introduction. Kidney Transplant Recipients (KTx) with donor-specific alloantibody (DSA) at transplantation have increased death-censored graft failure (DCGF) due to chronic antibody mediated rejection (cABMR), but…2018 American Transplant Congress
Acquired Resistance to Transplantation Tolerance as a Result of Prior Pregnancy Requires B Cells
Introduction: Clinical data suggest allogeneic pregnancy is a sensitizing event; yet, recent data from mouse models indicates it induces fetal-specific regulatory T cell (Treg) expansion…2018 American Transplant Congress
Targeting Plasma Cells with Anti-CD38mAb (Daratumumab) and CXCR4 Antagonist (Plerixafor) for Desensitization
1Surgery, Duke University, Durham, NC; 2Surgery, Mayo Clinic, Rochester, MN.
[Introduction] Sensitized patients comprise a significant portion (30%) of candidates on the transplant waiting list. Unfortunately for sensitized patients, the presence of donor-specific antibodies (DSA)…2018 American Transplant Congress
Parsing the 100% CPRA Kidney Transplant Candidates, Who Gets Transplanted?
Medicine, Sacred Heart Hospital, Pensacola, FL.
Currently the United States kidney allocation system gives priority to candidates with a CPRA of 100% by giving them additional allocation points and providing national…2018 American Transplant Congress
TACI-Ig as a Desensitization Agent in a Rat Model of Antibody Mediated Rejection
We examined the effect of APRIL/BLyS blockade on B cell lineages & donor specific antibody (DSA) in preclinical rodent model as a novel desensitization strategy.…2018 American Transplant Congress
Impact of KDPI and CPRA on Outcomes in Kidney Transplant Recipients
Cedars Sinai Medical Center, Los Angeles.
Introduction: The new KAS has led to a marked increase in kidney transplants among highly sensitized recipients, mostly attributable to higher allocation of low KDPI…
- « Previous Page
- 1
- …
- 8
- 9
- 10
- 11
- 12
- …
- 19
- Next Page »