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Articles tagged "Safety"

  • 2018 American Transplant Congress

    The First Series of Ischemia-Free Liver Transplantation in Human

    X. He,1 Z. Guo,1 S. Huang,1 Q. Zhao,1 Y. Tang,1 Z. Zhang,1 Z. Zhu,1 W. Ju,1 L. Yang,2 G. Chen.1

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; 2Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    BACKGROUND&AIMS: Ischemia and reperfusion injury (IRI) is known as an inevitable event leading to early and late graft failure. We have performed the first case…
  • 2018 American Transplant Congress

    Efficacy and Safety of Immediate- and Prolonged-Release Tacrolimus in De Novo Pediatric Transplantation: Randomized Study

    K. Vondrak,1 F. Parisi,2 A. Dhawan,3 R. Grenda,4 N. Webb,5 S. Marks,6 D. Debray,7 R. Holt,8 A. Lachaux,9 D. Kelly,10 G. Kazeem,11 N. Undre.11

    1University Hospital Motol, Prague, Czech Republic; 2Osp Pediatrico Bambino Ges[ugrave], Rome, Italy; 3King's College Hospital, London, United Kingdom; 4The Children's Memorial Health Institute, Warsaw, Poland; 5Manchester University Foundation Trust, Manchester, United Kingdom; 6Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; 7APHP-Hôpital Universitaire Necker, Paris, France; 8Alder Hey Children's Hospital, Liverpool, United Kingdom; 9Université Lyon 1 et Hospices Civils de Lyon, Lyon, France; 10Birmingham Children's Hospital, Birmingham, United Kingdom; 11Astellas Pharma Europe Ltd, Chertsey, United Kingdom.

    This study assessed long-term efficacy/safety of prolonged-release tacrolimus (PR-T) vs immediate-release tacrolimus (IR-T) in de novo pediatric transplant pts. Phase II, parallel-group, multicenter, open-label study…
  • 2018 American Transplant Congress

    Reducing No-Show Rate and Filling Cancelled Appointments: Multi-Faceted Interventions Markedly Reduced Time to Kidney Transplant Evaluation

    E. Gibney, K. Payne, C. Fowler.

    Piedmont Transplant Institute, Piedmont Atlanta Hospital, Atlanta, GA.

    Introduction: Time from referral to appointment for kidney transplant evaluation is an important metric. Demands of dialysis schedules and transportation logistics typically lead to high…
  • 2018 American Transplant Congress

    Procurement Travel Safety: Current Practices, Accident Frequency, Perceptions of Safety and Means to Reduce Risk

    A. Schenk, A. Adams, R. Lynch.

    Emory Transplant Center, Emory University, Atlanta, GA.

    Transplant procurement teams travel extensively. Though considered hazardous, little data on the necessity and risks of this travel exist. We conducted a survey of ASTS…
  • 2018 American Transplant Congress

    Medication Reconciliation in Abdominal Transplantation

    S. Todd,1 J. Perryman,2 R. Subramanian,2 A. Patel,2 M. Hawthorne,2 R. Buenvenida,2 K. Lee,2 W. Allison,2 D. Lo,2 P. Reshamwala.2

    1Department of Pharmacy, Emory University Hospital, Atlanta, GA; 2Emory Transplant Center, Emory University Hospital, Atlanta, GA.

    Medication adherence post transplantation is vital. Upon discharge, abdominal transplant patients receive a medication list from the electronic medical record (EMR) and obtain a medication…
  • 2018 American Transplant Congress

    12-Months Evolution of Anti-HLA Antibodies Donor Specific Antibodies after Rescue Switch from CNi-Based Immunosuppressive Regimen to Belatacept in Kidney Allograft Recipients

    M. Matignon,1 C. Dudreuilh,1 P. Rémy,1 J-.L. Taupin,2 P. Grimbert.1

    1Nephrology Transplantation, APHP Henri Mondor, Creteil, France; 2Histocompatibility, APHP Saint Louis, Paris, France.

    IntroductionAfter kidney transplantation, long-term immunosuppression with calcineurin inhibitors (CNIs) or mTOR inhibitors (mTORi) leads to adverse effects, such as nephrotoxicity and proteinuria. Currently, available data…
  • 2018 American Transplant Congress

    Everolimus with Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplant Recipients: Efficacy and Safety Outcomes from the TRANSFORM Study

    S. Mulgaonkar,1 J. Pascual,1 S. Chadban,1 H. Tedesco,1 S. Berger,1 Y. Qazi,1 C. Legendre,1 N. Basic-Jukic,1 P. Bernhardt,2 F. Vincenti.1

    1TRANSFORM Study Group, Livingston; 2Novartis Pharma AG, Basel, Switzerland.

    Purpose: Everolimus (EVR)-facilitated calcineurin inhibitor (CNI) reduction regimens help prevent long-term CNI nephrotoxicity in kidney transplant recipients (KTxRs). TRANSFORM (NCT01950819) is the largest study in…
  • 2018 American Transplant Congress

    Living Donor Nephrectomy: Is It as Safe as It Can Be? Analysis of Living Donor Deaths in the United States

    D. Keith,1 J. Brown,2 K. Andreoni.3

    1Medicine, Sacred Heart Hospital, Pensacola, FL; 2President, Clinical Integration Solutions, LLC, Health Safety Consultancy Company, New York, NY; 3Surgery, University of Florida, Gainesville, FL.

    The reported rate of death from living donor nephrectomy is 3 in 10,000 donations. Although this risk is low, the important question is how many…
  • 2018 American Transplant Congress

    Evaluation of Allergy to Tacrolimus in Kidney Transplant Candidates and Recipients with a History of Macrolide Antibiotic Allergy

    J. Trofe-Clark,1,2 M. Doshi,3 O. Fadugba,4 M. Lim.2

    1Pharmacy Services, Hospital of Univ. of Pennsylvania, Philadelphia, PA; 2Renal Division, Perelman School of Medicine, Univ. of Pennsylvania, Philadelphia, PA; 3Temple Univ. School of Pharmacy, Philadelphia, PA; 4Pulmonary Allergy Critical Care Division, Perelman School of Medicine, Univ. of Pennsylvania, Philadelphia, PA.

    Background: Tacrolimus (TAC) is considered a drug of choice for maintenance immunosuppression among kidney transplant (KTX) recipients. Because of structural resemblances between macrolide antibiotics (azithromycin,…
  • 2018 American Transplant Congress

    Opioid Use Following Ultrasound-Guided Transverse Abdominis Plane Blocks in Living Donor Nephrectomy Patients

    E. Henricksen,1 D. Quan,1 C. Freise.2

    1Department of Pharmacy, University of California, San Francisco, San Francisco, CA; 2Department of Surgery, University of California, San Francisco, San Francisco, CA.

    Purpose: Post-operative pain management is of major concern in living donor nephrectomy patients. Opioids are often used for post-surgical pain, however they are associated with…
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