ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Safety"

  • 2018 American Transplant Congress

    Effect of Early Attainment of Everolimus Target Trough Levels on Efficacy-Safety Outcomes in De Novo Kidney Transplant Recipients: 12-Month Results from US92 and TRANSFORM Studies

    F. Shihab,1 Y. Qazi,1,2 V. Peddi,1 D. Shaffer,1 D. Kim,1,2 K. McCague,3 D. Patel,3 S. Mulgaonkar.1,2

    1US92 Study Group, Salt Lake City; 2TRANSFORM Study Group, East Hanover; 3Novartis Pharmaceuticals Corporation, East Hanover.

    Purpose: Attainment of everolimus (EVR) target trough level (C0 3-8ng/mL) is crucial in achieving comparable efficacy-safety with EVR+reduced (r) calcineurin inhibitor regimen (CNI; tacrolimus [TAC]…
  • 2018 American Transplant Congress

    Pediatric Kidney Transplant in Norway – Results after Switching from Midline to Retroperitoneal Approach in Recipients below 25 kg

    R. Horneland, A. Khan, G. Steinar, T. Thorsen, M. Hagness.

    Section for Transplant Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

    Introduction: Pediatric kidney transplants demand a high level of surgical and medical involvement and skill. In Norway, all organ transplants are centralized and performed at…
  • 2018 American Transplant Congress

    mTOR Inhibition with Everolimus in De Novo Living Donor Liver Transplantation – 24-Months Results from the H2307 Pivotal Trial

    L. Jeng,1 S. Lee,1 A. Soin,1 S. Uemoto,1 D. Maluf,1 J. Emond,1 M. Meier,2 J. Kochuparampil,2 C. Sips,2 S. Kaneko,3 G. Levy.1

    1H2307 Study Group, Taichung, Taiwan; 2Novartis Pharma AG, Basel, Switzerland; 3Novartis Pharma KK, Tokyo, Japan.

    Purpose: Everolimus (EVR) with reduced-dose tacrolimus (rTAC) has been shown to be efficacious in preventing graft rejection and improving renal function in deceased-donor liver transplant…
  • 2018 American Transplant Congress

    Radiation Exposure to the Transplant Surgeon: A Case Study of Recent Yttrium-90 Treatment in an Explanted Liver

    M. Decoteau,1 P. Lewis,1 S. Steuterman,2 R. Schaffer,1 J. Fisher,1 J. Case,1 C. Marsh.1

    1Organ Transplantation, Scripps Green Hospital, La Jolla, CA; 2Medical Physics & Radiation Safety, Scripps Green Hospital, La Jolla, CA.

    BACKGROUND: Yttrium-90 (Y-90) radioembolization for the treatment of hepatocellular carcinoma can present safety challenges to the surgeon when transplanting a recently treated Y-90 patient. To…
  • 2018 American Transplant Congress

    The First Series of Ischemia-Free Liver Transplantation in Human

    X. He,1 Z. Guo,1 S. Huang,1 Q. Zhao,1 Y. Tang,1 Z. Zhang,1 Z. Zhu,1 W. Ju,1 L. Yang,2 G. Chen.1

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; 2Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    BACKGROUND&AIMS: Ischemia and reperfusion injury (IRI) is known as an inevitable event leading to early and late graft failure. We have performed the first case…
  • 2018 American Transplant Congress

    Efficacy and Safety of Immediate- and Prolonged-Release Tacrolimus in De Novo Pediatric Transplantation: Randomized Study

    K. Vondrak,1 F. Parisi,2 A. Dhawan,3 R. Grenda,4 N. Webb,5 S. Marks,6 D. Debray,7 R. Holt,8 A. Lachaux,9 D. Kelly,10 G. Kazeem,11 N. Undre.11

    1University Hospital Motol, Prague, Czech Republic; 2Osp Pediatrico Bambino Ges[ugrave], Rome, Italy; 3King's College Hospital, London, United Kingdom; 4The Children's Memorial Health Institute, Warsaw, Poland; 5Manchester University Foundation Trust, Manchester, United Kingdom; 6Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; 7APHP-Hôpital Universitaire Necker, Paris, France; 8Alder Hey Children's Hospital, Liverpool, United Kingdom; 9Université Lyon 1 et Hospices Civils de Lyon, Lyon, France; 10Birmingham Children's Hospital, Birmingham, United Kingdom; 11Astellas Pharma Europe Ltd, Chertsey, United Kingdom.

    This study assessed long-term efficacy/safety of prolonged-release tacrolimus (PR-T) vs immediate-release tacrolimus (IR-T) in de novo pediatric transplant pts. Phase II, parallel-group, multicenter, open-label study…
  • 2018 American Transplant Congress

    Reducing No-Show Rate and Filling Cancelled Appointments: Multi-Faceted Interventions Markedly Reduced Time to Kidney Transplant Evaluation

    E. Gibney, K. Payne, C. Fowler.

    Piedmont Transplant Institute, Piedmont Atlanta Hospital, Atlanta, GA.

    Introduction: Time from referral to appointment for kidney transplant evaluation is an important metric. Demands of dialysis schedules and transportation logistics typically lead to high…
  • 2018 American Transplant Congress

    Procurement Travel Safety: Current Practices, Accident Frequency, Perceptions of Safety and Means to Reduce Risk

    A. Schenk, A. Adams, R. Lynch.

    Emory Transplant Center, Emory University, Atlanta, GA.

    Transplant procurement teams travel extensively. Though considered hazardous, little data on the necessity and risks of this travel exist. We conducted a survey of ASTS…
  • 2018 American Transplant Congress

    Medication Reconciliation in Abdominal Transplantation

    S. Todd,1 J. Perryman,2 R. Subramanian,2 A. Patel,2 M. Hawthorne,2 R. Buenvenida,2 K. Lee,2 W. Allison,2 D. Lo,2 P. Reshamwala.2

    1Department of Pharmacy, Emory University Hospital, Atlanta, GA; 2Emory Transplant Center, Emory University Hospital, Atlanta, GA.

    Medication adherence post transplantation is vital. Upon discharge, abdominal transplant patients receive a medication list from the electronic medical record (EMR) and obtain a medication…
  • 2018 American Transplant Congress

    12-Months Evolution of Anti-HLA Antibodies Donor Specific Antibodies after Rescue Switch from CNi-Based Immunosuppressive Regimen to Belatacept in Kidney Allograft Recipients

    M. Matignon,1 C. Dudreuilh,1 P. Rémy,1 J-.L. Taupin,2 P. Grimbert.1

    1Nephrology Transplantation, APHP Henri Mondor, Creteil, France; 2Histocompatibility, APHP Saint Louis, Paris, France.

    IntroductionAfter kidney transplantation, long-term immunosuppression with calcineurin inhibitors (CNIs) or mTOR inhibitors (mTORi) leads to adverse effects, such as nephrotoxicity and proteinuria. Currently, available data…
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