ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Reverse transcriptase PCR"

  • 2022 American Transplant Congress

    EBV+ PTLD Tumor MicroRNAs Detected in Circulating Extracellular Vesicles Are Decreased in Pediatric Transplant Recipients with EBV+ PTLD

    A. Sen1, J. Enriquez1, M. Rao1, M. Glass1, Y. Balachandran1, S. Syed1, C. Twist1, K. Weinberg1, S. D. Boyd1, D. Bernstein1, A. Trickey1, D. Gratzinger1, B. Tan1, M. G. Lapasaran1, M. A. Robien2, M. Brown3, B. Armstrong4, M. Sever4, D. Desai5, G. Mazariegos6, C. Chin7, T. Fishbein8, R. S. Venick9, A. Tekin10, H. Zimmermann11, R. U. Trappe12, C. O. Esquivel1, O. M. Martinez1, S. M. Krams1

    1Stanford U, Palo Alto, CA, 2NIH, Bethesda, MD, 3NIAID, Bethesda, MD, 4Rho, Durham, NC, 5UT Southwestern, Dallas, TX, 6Pittsburgh U, Pittsburgh, PA, 7CCHMC, Cincinnati, OH, 8Georgetown U, Washington, DC, 9UCLA, LA, CA, 10Miami U, Miami, FL, 11DIAKO Ev. Diakonie-Krankenhaus, Bremen, Germany, 12Charité - Universitätsmedizin, Berlin, Germany

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation. Predisposing factors for PTLD include primary Epstein-Barr virus (EBV) infection in children,…
  • 2022 American Transplant Congress

    Kidney Transplantation Utilizing SARS-CoV-2 Rt-PCR Positive Donor Kidneys with Immediate Post Exposure Casirivimab /Imdevimab Followed by Thymoglobulin Induction

    S. K. Patel1, E. Siskind1, M. Laftavi1, J. Splinter1, E. Shipman2, S. Shah1, S. Nijim1, A. Adekile1, S. Asad1

    1Center for Transplantation, University Medical Center of Southern Nevada, Las Vegas, NV, 2Nevada Donor Network, Las Vegas, NV

    *Purpose: At the beginning of the pandemic, kidneys from SARS-CoV-2 (COVID) RT-PCR positive donors were not utilized for transplantation, due to the risk of viral…
  • 2021 American Transplant Congress

    A Noninvasive Diagnostic Approach for Molecular Monitoring of Face Transplant Recipients

    C. Snopkowski1, P. Rabbani2, H. Yang1, Z. Berman2, G. Diep2, C. Li1, T. Muthukumar1, R. Ding1, D. Ceradini2, M. Suthanthiran1

    1Weill Cornell Medical Institute, Department of Medicine, Division of Nephrology, NY, NY, 2NYU Langone Health, Hansjörg Wyss Department of Plastic Surgery, NY, NY

    *Purpose: Skin biopsies are currently the gold standard for evaluating the inflammatory status of face allografts. However, “tape stripping” is emerging as a noninvasive technique…
  • 2021 American Transplant Congress

    Results of Litmus (nct 02541916): The Liver Immune Tolerance Bio Marker Utilization Study

    A. Chruscinski1, V. Rojas-Luengas1, A. Issacher1, L. Lilly1, E. Renner1, M. Epstein1, O. Adeyi1, S. Fischer1, Z. Galvin1, S. Moshkelgosha1, E. Jaeckel2, S. Juvet1, N. Selzner1, G. Levy1

    1Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, 2Hannover Medical School, Hannover, Germany

    *Purpose: Although it is known that some liver transplant recipients are operationally tolerant and can be weaned off immunosuppression (IS), there is not currently a…
  • 2019 American Transplant Congress

    Results of Litmus (nct 02541916): The Liver Immune Tolerance Bio Marker Utilization Study

    A. Chruscinski1, V. Rojas-Luengas1, S. Moshkelgosha1, J. Luo2, H. Yowanto2, Z. Galvin1, L. Lilly1, R. Smith1, E. Renner1, J. Zhang1, D. Grant1, O. Adeyi1, H. Atkins3, P. Juni4, N. Selzner1, S. Juvet1, G. Levy1

    1Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, 2Sciex, Brea, CA, 3Ottawa Hospital Research Institute, Ottawa, ON, Canada, 4University of Toronto, Toronto, ON, Canada

    *Purpose: Previously we reported a novel biomarker gene set for the identification of tolerance in murine models of rapamycin-induced cardiac tolerance and spontaneous hepatic tolerance.…
  • 2017 American Transplant Congress

    Similar Elevation of Gene Expression Associated with Antibody-Mediated Rejection (ABMR) of Renal Allografts Can Be Detected in Both Plasma Exosomes (pExo) and Biopsies (Bx) by Assessing mRNA Transcript Profiles.

    H. Zhang,1 C. Nast,2 J. Doldron,2 M. Cheung,2 J. Mirocha,3 J. Kahwaji,1 A. Vo,1 S. Jordan,1 M. Toyoda.1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles; 2Pathology, Cedars-Sinai Medical Center, Los Angeles; 3Biostatistics Center, Cedars-Sinai Medical Center, Los Angeles

    Background: ABMR is a major obstacle for successful transplant in HLA-sensitized patients (Pts). Prediction of ABMR by non-invasive diagnostic tools is desirable. Previously we showed…
  • 2017 American Transplant Congress

    Biopsies (Bx) of Renal Allografts with Antibody- + Cell-Mediated Rejection (ABMR/CMR) Exhibit Gene Expression Signatures from Both Types of Rejection.

    H. Zhang,1 C. Nast,2 J. Doldron,2 M. Cheung,2 J. Mirocha,3 J. Kahwaji,1 A. Vo,1 S. Jordan,1 M. Toyoda.1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles; 2Pathology, Cedars-Sinai Medical Center, Los Angeles; 3Biostatistics Center, Cedars-Sinai Medical Center, Los Angeles

    Background: In HLA-sensitized kidney transplant patients (Pts) the concomitant presence of ABMR/CMR on Bx is associated with a more severe and (&) usually irreversible injury…
  • 2016 American Transplant Congress

    Identification of MicroRNAs in EBV+ B Cell Lymphomas and Secreted Exosomes.

    V. Kaul, A. Harris-Arnold, C. Esquivel, O. Martinez, S. Krams.

    Division of Abdominal Transplantation, Dept. of Surgery, Stanford University, Stanford.

    Introduction Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation commonly associated with Epstein Barr virus (EBV) infection. EBV viral loads are…
  • 2015 American Transplant Congress

    Non-Invasive Diagnosis of Post Kidney Transplant Complications by Urinary Exosomal mRNA Analysis

    H. Harada,1 T. Murakami,2 C. Yamamoto,2 M. Mitsuhashi.2

    1Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan; 2Hitachi Chemical Research Center, Inc., Irvine, CA.

    IntroductionMonitoring of kidney allograft status is important for the graft longevity. Conventional urinary markers are not sensitive and specific enough to diagnose graft injuries so…
  • 2015 American Transplant Congress

    Hypothermic Machine Preservation Reduces Inflammatory, Hypoxic and Apoptotic Injuries in Human Liver Transplantation

    J. Guarrera, C. Bae, S. Henry.

    Center for Liver Disease and Transplantation, Columbia University Medical Center, New York, NY.

    Introduction: Hypothermic machine perfusion (HMP) is in its infancy in Liver Transplantation. We analyzed all molecular samples from our cumulative clinical experience at Columbia University.Methods:…

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