ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Renal ischemia"

  • 2017 American Transplant Congress

    Postoperative Serum Lactate Dehydrogenase Is a "Troponin-Like" Marker of Renal Transplant Distress.

    R. Steiner, J. Halldorson.

    UCSD Center for Transplantation, University of California at San Diego, San Diego, CA

    Lactate dehydrogenase (LDH) is plentiful in renal tubular cells and is released during tubular injury or death. It increases for several days to 1500-2000 U/L…
  • 2017 American Transplant Congress

    Living Kidney Transplant: The Influence of Intraoperative Hemodynamics on Delayed Graft Function.

    R. Schutt,1 J. Case,1 B. Barrick,1 A. Toll,2 C. Marsh.1

    1Scripps Center for Organ and Cell Transplantation, Scripps Green Hospital, La Jolla, CA; 2Research Department and Analytics, UNOS, Richmond, VA

    Despite advantages of living donor kidneys, intraoperative insults may subject these kidneys to poor outcomes. Therefore, we investigated whether intraoperative fluid volumes and hemodynamics in…
  • 2017 American Transplant Congress

    Modulating Ischemia-Reperfusion Injuries with Pharmacological Agents: A Bench-to-Bedside Approach.

    M. Thomas, G. Tardif, A. Melanger, P. Berna.

    Balmes Transplantation, Marseille, France

    Ischemia–reperfusion (IR) is a complex pathophysiological process encompassing activation of inflammatory responses and cell death programs, the severity of which critically influences both the short…
  • 2017 American Transplant Congress

    Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.

    D. Aufhauser,1 D. Murken,1 Z. Wang,1 G. Ge,1 S. Concors,1 T. Bhatti,2 W. Hancock,2,3 M. Levine.1,4

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; 3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; 4Surgery, Children's Hospital of Philadelphia, Philadelphia, PA

    Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…
  • 2017 American Transplant Congress

    Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.

    D. Aufhauser Jr,1 D. Murken,1 Z. Wang,1 A. Samanta,2 G. Ge,1 T. Bhatti,3 P. Cole,4 J. Kalin,4 W. Hancock,2,3 M. Levine.1,5

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Pathology, University of Pennsylvania, Philadelphia, PA; 3Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; 4Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; 5Surgery, Children's Hospital of Philadelphia, Philadelphia, PA

    Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
  • 2017 American Transplant Congress

    Evaluation of Outcomes in Renal Transplantation Using Machine Perfusion for the Preservation of Kidneys from Expanded Criteria Donor.

    E. Savoye, M. Macher, Kidney Working Group, C. Legeai, C. Antoine.

    Agence de la Biomedecine, Saint Denis La Plaine, France

    Introduction:The shortage of kidney grafts led to retrieve organs from old donors with one or more co-morbidities, considered as “expanded criteria donors” (ECD). In France,…
  • 2017 American Transplant Congress

    The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.

    G. Weber,1 N. Ambrosi,2 F. Caro,2 S. Beltramino,1 A. Fernández,1 I. Cabrera,1 G. Hilchenbach,1 D. Fernandez,1 C. Incardona,3 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; 2CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; 3Fundación GADOR, Buenos Aires, Argentina

    A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…
  • 2016 American Transplant Congress

    Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.

    G. Zaza,1 V. Masola,1 G. Gambaro,2 M. Onisto,3 G. Bellin,1 I. Vlodavsky,4 Z. Abassi,5 A. Lupo.1

    1Renal Unit, Department of Medicine, University of Verona, Verona, Italy; 2Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; 3Department of Biomedical Sciences, University of Padova, Padova, Italy; 4Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; 5Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.

    Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
  • 2016 American Transplant Congress

    Role of TGF-β in Ischemia and Reperfusion Injury Induced Renal Fibrosis in Human Proximal Tubular Epithelial Cells.

    R. Kapoor, N. Sheerin, J. Kirby.

    Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.

    Ischemia-reperfusion injury (IRI) leads to an irreversible damage to the tubular epithelium and promotes acute kidney injury (AKI) that is associated with progressive loss of…
  • 2016 American Transplant Congress

    Cold Ischemia Induced Outcomes in Kidney Transplantation: A Meta-Analysis.

    D. Bennett, M. Mustafa, M. Chiles, W. Skillen, S. Mohan.

    Columbia University Medical Center, New York, NY.

    Objective: To examine the association between cold ischemia time (CIT) and delayed graft function (DGF) and death-censored graft failure in kidney transplantation.Methods: To identify relevant…
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