Articles tagged "Renal ischemia"

2017 American Transplant Congress
Impact of Belatacept Conversion on Kidney Transplant Function, Histology and Gene Expression.
P. Sanghi,¹ G. Gupta,¹ D. Kumar,¹ J. Reeve,² M. Levy,¹ A. Sharma,¹ H. Fattah,¹ P. Kimball,¹ H. Massey,¹ A. King,¹ P. Halloran.²
¹Virginia Commonwealth University, Richmond; ²Alberta Transplant Applied Genomics Center, Edmonton, Canada
Background: Belatacept (bela) might be an alternative to Calcineurin Inhibitors (CNI) in order to avoid presumed nephrotoxicity. In this study we assessed the impact of…
2017 American Transplant Congress
Direct Comparison of Hypothermic and Normothermic Organ Preservation in a Porcine Ex-Vivo Kidney Model.
N. Vallant,^1,2 B. Sandhu,¹ N. Wolfhagen,¹ C. Pusey,¹ V. Papalois.¹
¹Renal and Transplant Department, Imperial College, London, United Kingdom; ²Department of Visceral-, Transplant- and Thoracic Surgery, Medical University, Innsbruck, Austria
Background: Hypothermic machine perfusion is a well established method for deceased donor organ preservation as well as pre-transplant assessment and preconditioning. Recent translational and clinical…
2017 American Transplant Congress
Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.
N. Rogers,^1,2,3 D. Meijles,³ P. Pagano,³ J. Isenberg.³
¹Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, NSW, Australia; ²Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA; ³Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…
2017 American Transplant Congress
Renoprotective Effects of Carbon Monoxide–Releasing Molecule 3 in Ischemia Reperfusion Injury and Cisplatin-Induced Toxicity.
Y. Yoon,¹ H. Lee,¹ K. Huh,² M. Kim,² S. Kim,² Y. Kim,² W. Han.¹
¹Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; ²Transplantation Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Republic of Korea
Background: We investigated the effects of a soluble carbon monoxide–releasing molecule (CORM) in cisplatin-induced cytotoxicity and ischemia reperfusion injury (IRI) in vitro.Methods: The effects of…
2017 American Transplant Congress
Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.
M. Seyda,^1,2 M. Quante,¹ T. Heinbokel,¹ G. Liu,¹ H. Uehara,¹ J. Schuitenmaker,¹ R. Abdi,³ C. Falk,² A. Elkhal,¹ S. Tullius.¹
¹Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; ³Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston
Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…
2017 American Transplant Congress
Intravoxel Incoherent Motion MRI Is an Effective Way to Monitor Acute Allograft Rejection in Rat Models.
S. Zeng, X. Hu.
Urology, Chao-Yang Hospital, Beijing, China
Objectives: To combine the intravoxel incoherent motion MRI and blood oxygen level-dependent MRI for assessment of the renal allograft pathological process undergoing acute rejection and…
2017 American Transplant Congress
How to Promote Regeneration After Ischemic Reperfusion Injury: Dual Role of CD 137 Agonistic Antibody.
J. Lee,^1,3 H. Kim,³ H. Chung,¹ K. Park,¹ B. Kwon,^3,4 H. Cho.^2,3
¹Internal Medicine, Ulsan University Hospital and College of Medicine, University of Ulsan, Ulsan, Korea; ²Surgery, Ulsan University Hospital and College of Medicine, University, Ulsan, Korea; ³Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea; ⁴School of Biological Science, University of Ulsan, Ulsan, Korea
Acute sterile inflammation can be induced by tissue damage caused by ischemia-reperfusion. In transplantation ischemia reperfusion injury (IRI) is unavoidable procedure. IRI causes delayed graft…
2016 American Transplant Congress
Mitochondrial Membrane Potential Correlates with Ischemic Injury and Kidney Graft Function in Rats.
M. Chen, J. Huang, L. Qi, S. Kwon, R. Montgomery, Z. Sun.
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
BackgroundBoth short- and long-term outcomes of all organ transplants depend on the quality of the organ. Presently there is no completely reliable method to evaluate…
2016 American Transplant Congress
C1-Inhibitor Abrogated Ischemia/Reperfusion (I/R) Induced Inflammaging by Inhibiting Senescence-Associated Secretory Phenotype (SASP) in Tubular Epithelial Cells (TEC).
G. Castellano,¹ R. Franzin,¹ A. Stasi,¹ C. Divella,¹ M. Gigante,¹ S. Simone,¹ A. Intini,¹ A. Picerno,¹ P. Pontrelli,¹ A. Crovace,¹ M. Battaglia,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹
¹Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy; ²Pharming Technologies, Leiden, Netherlands; ³Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Inflammaging is a pathogenic process usually associated with chronic kidney disease such as diabetic nephropathy where TEC cells have a diminished regenerative potential and develop…
2016 American Transplant Congress
Predicting Delayed Kidney Graft Function with Gene Expression in Preimplantation Biopsies.
T. Mourão,^1,3 K. Mine,¹ E. Campos,^1,3 J. Medina-Pestana,^2,3 H. Tedesco-Silva,² M. Gerbase-De Lima.
¹Immunogenetics Institute, Associação Fundo de Incentivo à Pesquisa - AFIP, São Paulo, SP, Brazil; ²Hospital do Rim e Hipertensão, Fundação Oswaldo Ramos, São Paulo, SP, Brazil; ³UNIFESP, São Paulo, SP, Brazil.
Aiming to further the investigation of markers in pre-implantation biopsies (PIB) for the prediction of delayed graft function (DGF), we analyzed, in a different cohort…