2017 American Transplant Congress
Omega 3 Attenuates Ischemia Reperfusion Renal Injury via Enhancement of Autophagy Flux.
Purpose: Omega 3 fatty acid showed the protective effect against various renal injuries. Recently, it is reported that Omega 3 regulates the autophagy. Using fat-1…2017 American Transplant Congress
Extra-Renal Cardiac Injury Is Associated with Upregulation of NOD2 and Nlrp3 in the Heart After Renal IRI.
Medicine, Division of Nephrology and Hypertension, University of California San Diego, La Jolla, CA
Background: Recent studies show renal ischemia reperfusion injury (IRI) is associated with systemic release of danger associated molecular patterns (DAMPs). DMAPs induce significant extra-renal organ…2017 American Transplant Congress
Beneficial Effects of Hydrogen Sulfide (H2S) on Renal Ischemia-Reperfusion Injury (IRI) in CLAWN Miniature Swine.
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
Objective: The prevention of IRI is important for both early and long-term graft function, especially when using extended-criteria or donation after cardiac donors. H2S has…2017 American Transplant Congress
Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury.
Background: Dendritic cells (DC) are critical initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury (IRI). The mechanistic target of…2017 American Transplant Congress
ERK and HIF1 Play a Major Role in Hypothermic Protection Against Renal Ischemia-Reperfusion Injury.
Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…2017 American Transplant Congress
Impact of Belatacept Conversion on Kidney Transplant Function, Histology and Gene Expression.
Background: Belatacept (bela) might be an alternative to Calcineurin Inhibitors (CNI) in order to avoid presumed nephrotoxicity. In this study we assessed the impact of…2017 American Transplant Congress
Direct Comparison of Hypothermic and Normothermic Organ Preservation in a Porcine Ex-Vivo Kidney Model.
Background: Hypothermic machine perfusion is a well established method for deceased donor organ preservation as well as pre-transplant assessment and preconditioning. Recent translational and clinical…2016 American Transplant Congress
The Fine-Tuning of CXCL8 Protects Kidney Against Ischemia-Reperfusion Injury in Mice Lacking MicroRNA-146a.
Acute kidney injury leads to the development of tubular injury and interstitial inflammation that need to be controlled to avoid fibrosis development. We hypothesized that…2016 American Transplant Congress
Persufflation Improves Viability and Function of Porcine Kidneys Relative to Static Cold Storage.
The use of marginal organs demands optimization of organ storage and quality assessments prior to transplantation. Organs from donors after cardiac death (DCD) are exposed…2016 American Transplant Congress
Bioinformatic Analysis of Pathways Mediating Clusterin Functions in Kidney Cells Under Normoxia and Hypoxia.
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Background: Clusterin (CLU) is a chaperone-like protein and contributes to the resistance of the kidney to ischemia-reperfusion injury (IRI), however its pathways are not fully…
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