ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Renal ischemia"

  • 2017 American Transplant Congress

    Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.

    D. Aufhauser,1 D. Murken,1 Z. Wang,1 G. Ge,1 S. Concors,1 T. Bhatti,2 W. Hancock,2,3 M. Levine.1,4

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; 3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; 4Surgery, Children's Hospital of Philadelphia, Philadelphia, PA

    Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…
  • 2017 American Transplant Congress

    Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.

    D. Aufhauser Jr,1 D. Murken,1 Z. Wang,1 A. Samanta,2 G. Ge,1 T. Bhatti,3 P. Cole,4 J. Kalin,4 W. Hancock,2,3 M. Levine.1,5

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Pathology, University of Pennsylvania, Philadelphia, PA; 3Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; 4Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; 5Surgery, Children's Hospital of Philadelphia, Philadelphia, PA

    Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
  • 2017 American Transplant Congress

    Evaluation of Outcomes in Renal Transplantation Using Machine Perfusion for the Preservation of Kidneys from Expanded Criteria Donor.

    E. Savoye, M. Macher, Kidney Working Group, C. Legeai, C. Antoine.

    Agence de la Biomedecine, Saint Denis La Plaine, France

    Introduction:The shortage of kidney grafts led to retrieve organs from old donors with one or more co-morbidities, considered as “expanded criteria donors” (ECD). In France,…
  • 2017 American Transplant Congress

    The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.

    G. Weber,1 N. Ambrosi,2 F. Caro,2 S. Beltramino,1 A. Fernández,1 I. Cabrera,1 G. Hilchenbach,1 D. Fernandez,1 C. Incardona,3 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; 2CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; 3Fundación GADOR, Buenos Aires, Argentina

    A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…
  • 2017 American Transplant Congress

    Organs with Extended Cold Ischemia Time May Offer Aged Kidney Transplant Recipients New Options in an Expanded Donor Pool.

    M. Postalcioglu,1 B. Byun,1 A. Kaze,2 A. Siedlecki,1 E. Milford,2 R. Abdi.1

    1Transplantation Research Center, Brigham and Women's Hospital, Boston, MA; 2Renal Division, Brigham and Women's Hospital, Boston, MA

    Using data from the largest cohort of renal transplants, the aim of this study was to examine the effects of cold ischemia times (CIT) on…
  • 2017 American Transplant Congress

    Omega 3 Attenuates Ischemia Reperfusion Renal Injury via Enhancement of Autophagy Flux.

    J.-J. Kim,1 J. Jeong,2 D. Choi,3 K. Na,3 K. Lee.3

    1Chungnam National University, Anatomy, Daejeon, Korea; 2Chungnam National University, Department of Medical Science, Daejeon, Korea; 3Chungnam National University, Nephrology, Daejeon, Korea

    Purpose: Omega 3 fatty acid showed the protective effect against various renal injuries. Recently, it is reported that Omega 3 regulates the autophagy. Using fat-1…
  • 2017 American Transplant Congress

    Extra-Renal Cardiac Injury Is Associated with Upregulation of NOD2 and Nlrp3 in the Heart After Renal IRI.

    A. Scheinok, S. Kasimsetty, E. Soo, C. Nelson, A. Shigeoka, D. McKay.

    Medicine, Division of Nephrology and Hypertension, University of California San Diego, La Jolla, CA

    Background: Recent studies show renal ischemia reperfusion injury (IRI) is associated with systemic release of danger associated molecular patterns (DAMPs). DMAPs induce significant extra-renal organ…
  • 2017 American Transplant Congress

    Beneficial Effects of Hydrogen Sulfide (H2S) on Renal Ischemia-Reperfusion Injury (IRI) in CLAWN Miniature Swine.

    Y. Ariyoshi, M. Sekijima, H. Sahara, T. Murokawa, A. Shimizu, K. Yamada.

    Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan

    Objective: The prevention of IRI is important for both early and long-term graft function, especially when using extended-criteria or donation after cardiac donors. H2S has…
  • 2017 American Transplant Congress

    Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury.

    H. Dai,1,3 N. Rogers,1,2 A. Watson,1 D. Fantus,1 A. Thomson.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Westmead Institute for Medical Research, Sydney, Australia; 3Urologic Organ Transplantation Department, the Second Xiangya Hospital, Central South University, Changsha, China

    Background: Dendritic cells (DC) are critical initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury (IRI). The mechanistic target of…
  • 2017 American Transplant Congress

    ERK and HIF1 Play a Major Role in Hypothermic Protection Against Renal Ischemia-Reperfusion Injury.

    K. Lee,1 J. Jeong,2 D. Choi,1 K. Na,1 H. Bae,1 Y. Ham.1

    1Chungnam National University, Nephrology, Daejeon, Korea; 2Chungnam National University, Department of Medical Science, Daejeon, Korea

    Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
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