Articles tagged "Renal ischemia"

2016 American Transplant Congress
The Fine-Tuning of CXCL8 Protects Kidney Against Ischemia-Reperfusion Injury in Mice Lacking MicroRNA-146a.
L. Amrouche,^1,2 G. Desbuissons,¹ M. Rabant,^1,2 C. Legendre,^1,2 F. Terzi,² D. Anglicheau.^1,2
¹U1151, INSERM, Paris, France, Metropolitan; ²Department of Kidney Transplantation, Necker hospital, Paris, France, Metropolitan.
Acute kidney injury leads to the development of tubular injury and interstitial inflammation that need to be controlled to avoid fibrosis development. We hypothesized that…
2016 American Transplant Congress
Persufflation Improves Viability and Function of Porcine Kidneys Relative to Static Cold Storage.
C. Min,¹ L. Steyn,² A. Pandey,³ R. Harland,² J.-P. Galons,⁴ K. Papas.²
¹Physiology, University of Arizona, Tucson, AZ; ²Surgery, University of Arizona, Tucson, AZ; ³Electrical and Chemical Engineering, University of Arizona, Tucson, AZ; ⁴Medical Imaging, University of Arizona, Tucson, AZ.
The use of marginal organs demands optimization of organ storage and quality assessments prior to transplantation. Organs from donors after cardiac death (DCD) are exposed…
2016 American Transplant Congress
Bioinformatic Analysis of Pathways Mediating Clusterin Functions in Kidney Cells Under Normoxia and Hypoxia.
G. Dairi, Q. Guan, C. Collins, C. Ong, M. Gleave, C. Nguan, C. Du.
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Background: Clusterin (CLU) is a chaperone-like protein and contributes to the resistance of the kidney to ischemia-reperfusion injury (IRI), however its pathways are not fully…
2016 American Transplant Congress
NecroX-7 Attenuates Ischemia-Reperfusion Renal Injury.
K. Lee,¹ Y. Ham,¹ J. Jeon,¹ Y. Chang,² S. Chung,¹ K. Na,¹ D. Choi.¹
¹Renal Division, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea; ²Internal Medicine, Daejeon Saint Mary Hospital, College of Medicine, Catholic University, Daejeon, Korea.
Introduction: Recently mitochondrial damage has been known to play a major role in various renal injury mechanisms including ischemia-reperfusion (IR) renal injury. Mitochondrial injury and…
2015 American Transplant Congress
The Effects of Periostin on Renal Fibrosis After Ischemia-Reperfusion Injury Via p38 MAPK Pathway
J. An,^1,2 S. Yang,³ J. Hwang,⁴ J. Kim,¹ S. Kim,^2,5 C. Lim,^1,2 Y. Oh,^1,2 Y. Kim,² J. Lee.^1,2
¹Seoul National University Boramae Medical Center, Seoul, Republic of Korea; ²Seoul National University Hospital, Seoul, Republic of Korea; ³Seoul National University Kidney Research Institute, Seoul, Republic of Korea; ⁴Chung-Ang University Hospital, Seoul, Republic of Korea; ⁵Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Ischemia-reperfusion injury during the transplantation procedure is associated with poor long-term allograft outcomes, such as rejection and fibrosis. Periostin, a matricellular protein, has been reported…
2015 American Transplant Congress
Role of Complement in Mediating Pericyte Trans-Differentiation in Resident Myofibroblasts: A New Hypothesis On Vascular Rarefaction in Renal Ischemia/Reperfusion (I/R) Injury
G. Castellano,¹ R. Franzin,¹ C. Divella,¹ A. Stasi,¹ A. Intini,¹ M. Gigante,¹ G. Lucarelli,¹ P. Ditonno,¹ M. Battaglia,¹ A. Crovace,¹ F. Staffieri,¹ G. Pertosa,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹
¹University of Bari, Bari, Italy; ²Pharming Technologies NV, Leiden, Netherlands; ³University of Foggia, Foggia, Italy.
Vascular rarefaction is critical in the development of renal fibrosis. Pericytes regulate renal blood flow and might be an important source of renal interstitial myofibroblasts;…
2015 American Transplant Congress
Clusterin-Regulated Transcriptome in the Kidney During Ischemia-Reperfusion
G. Dairi, Q. Guan, A. Haegert, C. Collins, M. Gleave, C. Nguan, C. Du.
Department of Urological Sciences, Vancouver, Canada; The University of British Columbia, Vancouver, Canada; Immunity and Infection Research Centre, Vancouver, Canada; Vancouver Coastal Health Research Institute, Vancouver, Canada.
BACKGROUND: Ischemia-reperfusion injury (IRI) has a significate impact on both short and long-term transplant outcomes, and is a major cause of delayed graft function in…
2015 American Transplant Congress
Mitochondrial Hydrogen Sulphide Donor Molecules Are More Effective Against Hypoxic Injury in Renal Tubular Epithelial Cells
G. Aboalsamh,^1,5 M. Saha,² I. Lobb,² J. Grewal,² P. Luke,^1,2,3 M. Wood,⁴ M. Whiteman,⁴ A. Sener.^1,2,3
¹Urology, University of Western Ontario, London, Canada; ²Microbiology and Immunology, University of Western Ontario, London, Canada; ³University of Western Ontario, University of Western Ontario, London, Canada; ⁴Experimental Therapeutics, University of Exeter Medical School, Exeter, England, United Kingdom; ⁵Surgery, King Abdulaziz Medical Center, Jeddah, Saudi Arabia.
Introduction: Ischemia reperfusion injury (IRI) in organ transplant often manifests itself as delayed graft function (DGF). DGF is associated with increased morbidity and deleterious effects…
2015 American Transplant Congress
Phenotype of Renal Tubular Cell Death During Delayed Graft Function
S. Jain,¹ R. Plenter,¹ T. Nydam,¹ C. Ruller,¹ C. Edelstein,^1,2 A. Jani.^1,2
¹University of Colorado, Aurora, CO; ²Veterans Affairs Medical Center, Denver, CO.
Background: Delayed graft function (DGF) independently predicts reduced 5 yr kidney transplant survival. Treatments of DGF are lacking. Cold ischemia (CI) is a significant risk…
2015 American Transplant Congress
Perfusion Disturbances and Local Infarctions After Experimental Kidney Transplantation Corralte With the Duration of Cold Ischemia Time
S. Rong,¹ R. Chen,¹ M. Meier,⁴ B. Hensen,² H. Haller,¹ K. Hueper,² F. Gueler.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Radiology, Hannover Medical School, Hannover, Germany; ³Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ⁴Imaging Center, Hannover Medical School, Hannover, Germany.
Background: Kidney transplantation in mice is challenging but offers good translational models to study mechanisms of disease. In this study allogenic and isogenic kidney transplantation…