2016 American Transplant Congress
Ischemia-Reperfusion Injury Following Transplantation: Implications for the Modulation of CXCL8 Chemokine Function.
Ischemia-Reperfusion Injury (IRI) is a major contributor to subsequent graft dysfunction. Chemokines play a key role in leukocyte recruitment towards to the injured tissue. CXCL8…2016 American Transplant Congress
Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank.
The onset of abnormal pathophysiological changes following brain death adversely impact kidney function following transplantation. Understanding the biological mechanisms that affect kidney quality will allow…2016 American Transplant Congress
Local Infusion of MyD88 Inhibitor Inhibits Ischemia-Reperfusion Kidney Injury.
We have previously shown that tubular epithelial cells play a central role in regulating ischemia-reperfusion kidney injury (K-IRI). Tubular epithelial cells damaged by hypoxic insult…2016 American Transplant Congress
Defective Post-Reperfusion Metabolic Recovery Directly Associates with Incident Delayed Graft Function.
Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Delayed graft function (DGF) following kidney transplantation detrimentally affects long-term graft function and survival. DGF is a manifestation of ischemia reperfusion (I/R) injury, yet up…2015 American Transplant Congress
Distinct Role of Complement Receptors C5L2 and C5aR in Acute Kidney Injury and Renal Fibrosis
ObjectiveAcute kidney injury (AKI) is a relevant complication in solid organ transplantation with incidence rates of ∼50-75 % after lung- and heart transplantation. In addition,…2015 American Transplant Congress
In Pre-Implantation Biopsies Expression of Micro RNAs Is Not a Good Surrogate for Established mRNA Markers of Kidney Injury
1University of Alberta, Edmonton, Canada; 2University of Marlyland, Baltimore.
Kidneys from brain dead donors>50 years old are often discarded based on conventional (clinical and histologic) criteria, despite their poor predictive value for subsequent performance…2015 American Transplant Congress
Anti-LG3 Antibodies Aggravate Ischemia-Reperfusion Injury
Ischemia-Reperfusion Injury (IRI) is a significant cause of renal allograft dysfunction and a risk factor for poor long-term graft outcomes. Microvascular injury is an important…2015 American Transplant Congress
Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation
IntroductionDespite the persistent shortage of donor organs, paradoxically, many organs obtained from older higher risk donors are deemed unsuitable for transplantation and discarded. The ability…2015 American Transplant Congress
The Effects of Periostin on Renal Fibrosis After Ischemia-Reperfusion Injury Via p38 MAPK Pathway
Ischemia-reperfusion injury during the transplantation procedure is associated with poor long-term allograft outcomes, such as rejection and fibrosis. Periostin, a matricellular protein, has been reported…2015 American Transplant Congress
Role of Complement in Mediating Pericyte Trans-Differentiation in Resident Myofibroblasts: A New Hypothesis On Vascular Rarefaction in Renal Ischemia/Reperfusion (I/R) Injury
Vascular rarefaction is critical in the development of renal fibrosis. Pericytes regulate renal blood flow and might be an important source of renal interstitial myofibroblasts;…
American Transplant Congress abstracts