2016 American Transplant Congress
Mitochondrial Membrane Potential Correlates with Ischemic Injury and Kidney Graft Function in Rats.
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
BackgroundBoth short- and long-term outcomes of all organ transplants depend on the quality of the organ. Presently there is no completely reliable method to evaluate…2016 American Transplant Congress
C1-Inhibitor Abrogated Ischemia/Reperfusion (I/R) Induced Inflammaging by Inhibiting Senescence-Associated Secretory Phenotype (SASP) in Tubular Epithelial Cells (TEC).
Inflammaging is a pathogenic process usually associated with chronic kidney disease such as diabetic nephropathy where TEC cells have a diminished regenerative potential and develop…2016 American Transplant Congress
Predicting Delayed Kidney Graft Function with Gene Expression in Preimplantation Biopsies.
Aiming to further the investigation of markers in pre-implantation biopsies (PIB) for the prediction of delayed graft function (DGF), we analyzed, in a different cohort…2016 American Transplant Congress
Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.
ObjectiveThe complement receptors C5aR1 and C5aR2 serve distinct roles in immune regulation. In kidney transplantation the early post-implant ischemia reperfusion injury (IRI) causes rapid complement…2015 American Transplant Congress
Phenotype of Renal Tubular Cell Death During Delayed Graft Function
1University of Colorado, Aurora, CO; 2Veterans Affairs Medical Center, Denver, CO.
Background: Delayed graft function (DGF) independently predicts reduced 5 yr kidney transplant survival. Treatments of DGF are lacking. Cold ischemia (CI) is a significant risk…2015 American Transplant Congress
Perfusion Disturbances and Local Infarctions After Experimental Kidney Transplantation Corralte With the Duration of Cold Ischemia Time
Background: Kidney transplantation in mice is challenging but offers good translational models to study mechanisms of disease. In this study allogenic and isogenic kidney transplantation…2015 American Transplant Congress
Chemokine Receptor 5 Blockade Modulates Inflammation and Immunity in Renal Ischemic Reperfusion Injury
Macrophages, which exhibit great pliability, are important components of renal ischemic reperfusion injury (IRI) and are closely correlated with loss of renal function. Chemokine Receptor…2015 American Transplant Congress
Distinct Role of Complement Receptors C5L2 and C5aR in Acute Kidney Injury and Renal Fibrosis
ObjectiveAcute kidney injury (AKI) is a relevant complication in solid organ transplantation with incidence rates of ∼50-75 % after lung- and heart transplantation. In addition,…2015 American Transplant Congress
In Pre-Implantation Biopsies Expression of Micro RNAs Is Not a Good Surrogate for Established mRNA Markers of Kidney Injury
1University of Alberta, Edmonton, Canada; 2University of Marlyland, Baltimore.
Kidneys from brain dead donors>50 years old are often discarded based on conventional (clinical and histologic) criteria, despite their poor predictive value for subsequent performance…2015 American Transplant Congress
Anti-LG3 Antibodies Aggravate Ischemia-Reperfusion Injury
Ischemia-Reperfusion Injury (IRI) is a significant cause of renal allograft dysfunction and a risk factor for poor long-term graft outcomes. Microvascular injury is an important…
American Transplant Congress abstracts