Articles tagged "Renal ischemia"

2016 American Transplant Congress
NecroX-7 Attenuates Ischemia-Reperfusion Renal Injury.
K. Lee,¹ Y. Ham,¹ J. Jeon,¹ Y. Chang,² S. Chung,¹ K. Na,¹ D. Choi.¹
¹Renal Division, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea; ²Internal Medicine, Daejeon Saint Mary Hospital, College of Medicine, Catholic University, Daejeon, Korea.
Introduction: Recently mitochondrial damage has been known to play a major role in various renal injury mechanisms including ischemia-reperfusion (IR) renal injury. Mitochondrial injury and…
2016 American Transplant Congress
Mitochondrial Membrane Potential Correlates with Ischemic Injury and Kidney Graft Function in Rats.
M. Chen, J. Huang, L. Qi, S. Kwon, R. Montgomery, Z. Sun.
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
BackgroundBoth short- and long-term outcomes of all organ transplants depend on the quality of the organ. Presently there is no completely reliable method to evaluate…
2016 American Transplant Congress
C1-Inhibitor Abrogated Ischemia/Reperfusion (I/R) Induced Inflammaging by Inhibiting Senescence-Associated Secretory Phenotype (SASP) in Tubular Epithelial Cells (TEC).
G. Castellano,¹ R. Franzin,¹ A. Stasi,¹ C. Divella,¹ M. Gigante,¹ S. Simone,¹ A. Intini,¹ A. Picerno,¹ P. Pontrelli,¹ A. Crovace,¹ M. Battaglia,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹
¹Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy; ²Pharming Technologies, Leiden, Netherlands; ³Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Inflammaging is a pathogenic process usually associated with chronic kidney disease such as diabetic nephropathy where TEC cells have a diminished regenerative potential and develop…
2016 American Transplant Congress
Predicting Delayed Kidney Graft Function with Gene Expression in Preimplantation Biopsies.
T. Mourão,^1,3 K. Mine,¹ E. Campos,^1,3 J. Medina-Pestana,^2,3 H. Tedesco-Silva,² M. Gerbase-De Lima.
¹Immunogenetics Institute, Associação Fundo de Incentivo à Pesquisa - AFIP, São Paulo, SP, Brazil; ²Hospital do Rim e Hipertensão, Fundação Oswaldo Ramos, São Paulo, SP, Brazil; ³UNIFESP, São Paulo, SP, Brazil.
Aiming to further the investigation of markers in pre-implantation biopsies (PIB) for the prediction of delayed graft function (DGF), we analyzed, in a different cohort…
2016 American Transplant Congress
Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.
A. Thorenz,¹ R. Chen,¹ K. Hueper,² B. Hensen,² C. Klemann,³ M. Meier,⁴ A. Klos,⁵ F. Gueler.¹
¹Nephrology, Medical School, Hannover, Germany; ²Radiology, Medical School, Hannover, Germany; ³Paediatric Surgery, Medical School, Hannover, Germany; ⁴Central Animal Facility, Medical School, Hannover, Germany; ⁵Microbiology, Medical School, Hannover, Germany.
ObjectiveThe complement receptors C5aR1 and C5aR2 serve distinct roles in immune regulation. In kidney transplantation the early post-implant ischemia reperfusion injury (IRI) causes rapid complement…
2016 American Transplant Congress
Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.
J. Leigh,¹ P. Shao,¹ M. Saha,¹ I. Lobb,¹ A. Pasch,⁵ H. van Goor,⁴ M. Feelisch,² R. Wang,³ A. Sener.¹
¹Western University, London, Canada; ²University of Southhampton, Southhampton, United Kingdom; ³Lakehead University, Thunder Bay, Canada; ⁴University of Gronigen, Groningen, Netherlands; ⁵University Hospital Bern, Bern, Switzerland.
Anemia affects 90% of hemodialysis patients and is a tremendous concern for patients and health care providers. CKD leads to chronic interstitial fibrosis which leads…
2016 American Transplant Congress
Ischemia-Reperfusion Injury Following Transplantation: Implications for the Modulation of CXCL8 Chemokine Function.
B. Martinez Burgo,¹ S. Ali,¹ J. Kirby,¹ N. Sheerin,¹ S. Cobb,² D. Kashanin.³
¹Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom; ²Chemistry Department, Durham University, Durham, United Kingdom; ³Cellix Ltd., Dublin, Ireland.
Ischemia-Reperfusion Injury (IRI) is a major contributor to subsequent graft dysfunction. Chemokines play a key role in leukocyte recruitment towards to the injured tissue. CXCL8…
2016 American Transplant Congress
Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank.
M. Kaisar,¹ L. van Dullemen,² Z. Akhtar,¹ M. Lo Faro,¹ H. Huang,¹ H. Leuvenink,² B. Kessler,¹ R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²UMCG, UMCG, Groningen, Netherlands.
The onset of abnormal pathophysiological changes following brain death adversely impact kidney function following transplantation. Understanding the biological mechanisms that affect kidney quality will allow…
2016 American Transplant Congress
Local Infusion of MyD88 Inhibitor Inhibits Ischemia-Reperfusion Kidney Injury.
H. Cho,^1,3 J. Lee,^1,4 H. Kim,^1,2 Y. Han,² B. Kwon,^1,2 S. Park,^1,3 K. Park.⁴
¹Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ²School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea; ³Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ⁴Department of Internal Medicine, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea.
We have previously shown that tubular epithelial cells play a central role in regulating ischemia-reperfusion kidney injury (K-IRI). Tubular epithelial cells damaged by hypoxic insult…
2016 American Transplant Congress
Defective Post-Reperfusion Metabolic Recovery Directly Associates with Incident Delayed Graft Function.
L. Wijermars, A. Schaapherder, J. Lindeman.
Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Delayed graft function (DGF) following kidney transplantation detrimentally affects long-term graft function and survival. DGF is a manifestation of ischemia reperfusion (I/R) injury, yet up…