Articles tagged "Renal ischemia"

2016 American Transplant Congress
Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.
A. Thorenz,¹ R. Chen,¹ K. Hueper,² B. Hensen,² C. Klemann,³ M. Meier,⁴ A. Klos,⁵ F. Gueler.¹
¹Nephrology, Medical School, Hannover, Germany; ²Radiology, Medical School, Hannover, Germany; ³Paediatric Surgery, Medical School, Hannover, Germany; ⁴Central Animal Facility, Medical School, Hannover, Germany; ⁵Microbiology, Medical School, Hannover, Germany.
ObjectiveThe complement receptors C5aR1 and C5aR2 serve distinct roles in immune regulation. In kidney transplantation the early post-implant ischemia reperfusion injury (IRI) causes rapid complement…
2016 American Transplant Congress
Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.
J. Leigh,¹ P. Shao,¹ M. Saha,¹ I. Lobb,¹ A. Pasch,⁵ H. van Goor,⁴ M. Feelisch,² R. Wang,³ A. Sener.¹
¹Western University, London, Canada; ²University of Southhampton, Southhampton, United Kingdom; ³Lakehead University, Thunder Bay, Canada; ⁴University of Gronigen, Groningen, Netherlands; ⁵University Hospital Bern, Bern, Switzerland.
Anemia affects 90% of hemodialysis patients and is a tremendous concern for patients and health care providers. CKD leads to chronic interstitial fibrosis which leads…
2016 American Transplant Congress
Ischemia-Reperfusion Injury Following Transplantation: Implications for the Modulation of CXCL8 Chemokine Function.
B. Martinez Burgo,¹ S. Ali,¹ J. Kirby,¹ N. Sheerin,¹ S. Cobb,² D. Kashanin.³
¹Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom; ²Chemistry Department, Durham University, Durham, United Kingdom; ³Cellix Ltd., Dublin, Ireland.
Ischemia-Reperfusion Injury (IRI) is a major contributor to subsequent graft dysfunction. Chemokines play a key role in leukocyte recruitment towards to the injured tissue. CXCL8…
2016 American Transplant Congress
Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank.
M. Kaisar,¹ L. van Dullemen,² Z. Akhtar,¹ M. Lo Faro,¹ H. Huang,¹ H. Leuvenink,² B. Kessler,¹ R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²UMCG, UMCG, Groningen, Netherlands.
The onset of abnormal pathophysiological changes following brain death adversely impact kidney function following transplantation. Understanding the biological mechanisms that affect kidney quality will allow…
2016 American Transplant Congress
Local Infusion of MyD88 Inhibitor Inhibits Ischemia-Reperfusion Kidney Injury.
H. Cho,^1,3 J. Lee,^1,4 H. Kim,^1,2 Y. Han,² B. Kwon,^1,2 S. Park,^1,3 K. Park.⁴
¹Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ²School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea; ³Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ⁴Department of Internal Medicine, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea.
We have previously shown that tubular epithelial cells play a central role in regulating ischemia-reperfusion kidney injury (K-IRI). Tubular epithelial cells damaged by hypoxic insult…
2016 American Transplant Congress
Defective Post-Reperfusion Metabolic Recovery Directly Associates with Incident Delayed Graft Function.
L. Wijermars, A. Schaapherder, J. Lindeman.
Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Delayed graft function (DGF) following kidney transplantation detrimentally affects long-term graft function and survival. DGF is a manifestation of ischemia reperfusion (I/R) injury, yet up…
2016 American Transplant Congress
Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.
G. Zaza,¹ V. Masola,¹ G. Gambaro,² M. Onisto,³ G. Bellin,¹ I. Vlodavsky,⁴ Z. Abassi,⁵ A. Lupo.¹
¹Renal Unit, Department of Medicine, University of Verona, Verona, Italy; ²Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; ³Department of Biomedical Sciences, University of Padova, Padova, Italy; ⁴Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; ⁵Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
2016 American Transplant Congress
Role of TGF-β in Ischemia and Reperfusion Injury Induced Renal Fibrosis in Human Proximal Tubular Epithelial Cells.
R. Kapoor, N. Sheerin, J. Kirby.
Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Ischemia-reperfusion injury (IRI) leads to an irreversible damage to the tubular epithelium and promotes acute kidney injury (AKI) that is associated with progressive loss of…
2016 American Transplant Congress
Cold Ischemia Induced Outcomes in Kidney Transplantation: A Meta-Analysis.
D. Bennett, M. Mustafa, M. Chiles, W. Skillen, S. Mohan.
Columbia University Medical Center, New York, NY.
Objective: To examine the association between cold ischemia time (CIT) and delayed graft function (DGF) and death-censored graft failure in kidney transplantation.Methods: To identify relevant…
2016 American Transplant Congress
Adopting the Kidney Donor Profile Index (KDPI)/Kidney Donor Risk Index (KDRI) for Japanese Donors After Cardiac Death.
M. Kusaka,¹ A. Kawai,¹ N. Fukami,¹ H. Sasaki,¹ H. Takahashi,² T. Ito,³ T. Kenmochi,³ R. Shiroki,¹ K. Hoshinaga.¹
¹Urology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ²Division of Medical Statistics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ³Organ Transplant Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Introduction: Due to a severe organ shortage, it is important to predict the outcome of grafts prior to kidney transplantation and establish an appropriate allocation…