Articles tagged "Renal ischemia"

2016 American Transplant Congress
Adopting the Kidney Donor Profile Index (KDPI)/Kidney Donor Risk Index (KDRI) for Japanese Donors After Cardiac Death.
M. Kusaka,¹ A. Kawai,¹ N. Fukami,¹ H. Sasaki,¹ H. Takahashi,² T. Ito,³ T. Kenmochi,³ R. Shiroki,¹ K. Hoshinaga.¹
¹Urology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ²Division of Medical Statistics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ³Organ Transplant Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Introduction: Due to a severe organ shortage, it is important to predict the outcome of grafts prior to kidney transplantation and establish an appropriate allocation…
2016 American Transplant Congress
The Fine-Tuning of CXCL8 Protects Kidney Against Ischemia-Reperfusion Injury in Mice Lacking MicroRNA-146a.
L. Amrouche,^1,2 G. Desbuissons,¹ M. Rabant,^1,2 C. Legendre,^1,2 F. Terzi,² D. Anglicheau.^1,2
¹U1151, INSERM, Paris, France, Metropolitan; ²Department of Kidney Transplantation, Necker hospital, Paris, France, Metropolitan.
Acute kidney injury leads to the development of tubular injury and interstitial inflammation that need to be controlled to avoid fibrosis development. We hypothesized that…
2016 American Transplant Congress
Persufflation Improves Viability and Function of Porcine Kidneys Relative to Static Cold Storage.
C. Min,¹ L. Steyn,² A. Pandey,³ R. Harland,² J.-P. Galons,⁴ K. Papas.²
¹Physiology, University of Arizona, Tucson, AZ; ²Surgery, University of Arizona, Tucson, AZ; ³Electrical and Chemical Engineering, University of Arizona, Tucson, AZ; ⁴Medical Imaging, University of Arizona, Tucson, AZ.
The use of marginal organs demands optimization of organ storage and quality assessments prior to transplantation. Organs from donors after cardiac death (DCD) are exposed…
2016 American Transplant Congress
Bioinformatic Analysis of Pathways Mediating Clusterin Functions in Kidney Cells Under Normoxia and Hypoxia.
G. Dairi, Q. Guan, C. Collins, C. Ong, M. Gleave, C. Nguan, C. Du.
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Background: Clusterin (CLU) is a chaperone-like protein and contributes to the resistance of the kidney to ischemia-reperfusion injury (IRI), however its pathways are not fully…
2016 American Transplant Congress
NecroX-7 Attenuates Ischemia-Reperfusion Renal Injury.
K. Lee,¹ Y. Ham,¹ J. Jeon,¹ Y. Chang,² S. Chung,¹ K. Na,¹ D. Choi.¹
¹Renal Division, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea; ²Internal Medicine, Daejeon Saint Mary Hospital, College of Medicine, Catholic University, Daejeon, Korea.
Introduction: Recently mitochondrial damage has been known to play a major role in various renal injury mechanisms including ischemia-reperfusion (IR) renal injury. Mitochondrial injury and…
2016 American Transplant Congress
Mitochondrial Membrane Potential Correlates with Ischemic Injury and Kidney Graft Function in Rats.
M. Chen, J. Huang, L. Qi, S. Kwon, R. Montgomery, Z. Sun.
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
BackgroundBoth short- and long-term outcomes of all organ transplants depend on the quality of the organ. Presently there is no completely reliable method to evaluate…
2016 American Transplant Congress
C1-Inhibitor Abrogated Ischemia/Reperfusion (I/R) Induced Inflammaging by Inhibiting Senescence-Associated Secretory Phenotype (SASP) in Tubular Epithelial Cells (TEC).
G. Castellano,¹ R. Franzin,¹ A. Stasi,¹ C. Divella,¹ M. Gigante,¹ S. Simone,¹ A. Intini,¹ A. Picerno,¹ P. Pontrelli,¹ A. Crovace,¹ M. Battaglia,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹
¹Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy; ²Pharming Technologies, Leiden, Netherlands; ³Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Inflammaging is a pathogenic process usually associated with chronic kidney disease such as diabetic nephropathy where TEC cells have a diminished regenerative potential and develop…
2016 American Transplant Congress
Predicting Delayed Kidney Graft Function with Gene Expression in Preimplantation Biopsies.
T. Mourão,^1,3 K. Mine,¹ E. Campos,^1,3 J. Medina-Pestana,^2,3 H. Tedesco-Silva,² M. Gerbase-De Lima.
¹Immunogenetics Institute, Associação Fundo de Incentivo à Pesquisa - AFIP, São Paulo, SP, Brazil; ²Hospital do Rim e Hipertensão, Fundação Oswaldo Ramos, São Paulo, SP, Brazil; ³UNIFESP, São Paulo, SP, Brazil.
Aiming to further the investigation of markers in pre-implantation biopsies (PIB) for the prediction of delayed graft function (DGF), we analyzed, in a different cohort…
2016 American Transplant Congress
Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.
A. Thorenz,¹ R. Chen,¹ K. Hueper,² B. Hensen,² C. Klemann,³ M. Meier,⁴ A. Klos,⁵ F. Gueler.¹
¹Nephrology, Medical School, Hannover, Germany; ²Radiology, Medical School, Hannover, Germany; ³Paediatric Surgery, Medical School, Hannover, Germany; ⁴Central Animal Facility, Medical School, Hannover, Germany; ⁵Microbiology, Medical School, Hannover, Germany.
ObjectiveThe complement receptors C5aR1 and C5aR2 serve distinct roles in immune regulation. In kidney transplantation the early post-implant ischemia reperfusion injury (IRI) causes rapid complement…
2016 American Transplant Congress
Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.
J. Leigh,¹ P. Shao,¹ M. Saha,¹ I. Lobb,¹ A. Pasch,⁵ H. van Goor,⁴ M. Feelisch,² R. Wang,³ A. Sener.¹
¹Western University, London, Canada; ²University of Southhampton, Southhampton, United Kingdom; ³Lakehead University, Thunder Bay, Canada; ⁴University of Gronigen, Groningen, Netherlands; ⁵University Hospital Bern, Bern, Switzerland.
Anemia affects 90% of hemodialysis patients and is a tremendous concern for patients and health care providers. CKD leads to chronic interstitial fibrosis which leads…