Articles tagged "Renal injury"

2019 American Transplant Congress
Utilization of Donor Kidneys with Acute Kidney Injury in Pediatric Transplantation
C. S. Hwang¹, B. Tanriover², S. Levea², D. Desai¹, V. Ariyamuthu², P. Vagefi¹, M. MacConmara¹
¹Surgery, UT Southwestern, Dallas, TX, ²Medicine, UT Southwestern, Dallas, TX
*Purpose: Donor kidneys that are otherwise healthy with acute kidney injury (AKI) are increasingly used in adult transplant programs. We sought to examine the experience…
2019 American Transplant Congress
Impact of Donor Acute Kidney Injury on GFR at 1 Year
R. Heilman, A. Kumar, A. Srinivasan, M. Smith, J. Huskey, H. Khamash, A. Mathur, C. Jadlowiec, A. Moss, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: GFR 1-year after kidney transplantation is a marker for long term graft survival. The aim of this study is to determine the impact of…
2019 American Transplant Congress
Anti-Donor M H C Class I I Alloantibody Induce Glomerular Injury in Mouse Renal Allografts Subjected to Prolonged Cold Ischemia
V. Gorbacheva, R. Fan, A. Beavers, R. Fairchild, W. Baldwin, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury.The goal of this study…
2019 American Transplant Congress
Impact of Donor Acute Kidney Injury on the Outcome of Graft Delayed Graft Function
C. Jadlowiec, A. Kumar, A. Srinivasan, A. Mathur, M. Smith, J. Huskey, A. Moss, H. Khamash, R. L. Heilman, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: Kidneys from deceased donors with acute kidney injury (AKI) have a higher risk of delayed graft function (DGF). The aim of this study was…
2019 American Transplant Congress
Donor Derived Cell Free DNA Initiates De-Novo Donor Specific Antibody (DSA) Responses
S. Jordan¹, D. Sawinski², S. Dholakia³
¹Cedars-Sinai, Los Angeles, CA, ²Hospital of the University of Pennsylvania, Philadelphia, PA, ³CareDx, Brisbane, CA
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury, may contribute to sensitization of the recipients’ immune system. Antigenic presentation of donor-derived nucleic acids,…
2019 American Transplant Congress
Determinants of Allograft Injury during Procurement in Deceased Donors
E. Taber-Hight¹, R. Cauwels², E. Eidbo², A. S. Paramesh³, R. Squires⁴, T. Taber¹
¹Nephrology, Indiana University, Indianapolis, IN, ²AOPO, Vienna, VA, ³Louisiana Organ Procurement Agency, New Orleans, LA, ⁴University of Oklahoma, Oklahoma City, OK
*Purpose: With the ever enlarging list of potential recipients on the transplant list, the need for deceased donor organs has become critical. Avoiding injury to…
2019 American Transplant Congress
Outcomes and Clinical Utility of the kSORT Assay in the Prism Prospective Clinical Trial of Highly Sensitized Kidney Transplant Recipients
A. Schroeder, P. Towfighi, C. Hu, S. Hsieh, J. Liberto, I. Damm, T. Sigdel, P. Millar, M. Sarwal, F. Vincenti
Department of Surgery, UCSF, San Francisco, CA
*Purpose: kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of biopsy proven acute rejection (AR) and immune quiescence in kidney transplantation…
2019 American Transplant Congress
Activation of Renal Fibroblasts by Anti- Major Histocompatibility Complex Antibody: A Missing Link in Allograft Fibrosis
M. B. Oliver¹, J. Chen², A. Zmijewska¹, R. B. Mannon¹
¹Medicine, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, AL, ²Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, AL
*Purpose: Chronic antibody-mediated rejection (CAMR) is an important contributor to late kidney allograft loss, frequently accompanied by interstitial fibrosis and tubular atrophy. Donor-specific antibodies (DSA)…
2019 American Transplant Congress
Lineage Tracing Identifies C-Kit Cells as a Population of Kidney-Specific Stem Cells during Development and in Acute and Chronic Kidney Diseases
E. B. Rangel¹, E. Higuti-Sousa¹, G. Goss², B. Goldstein², B. Seidler³, D. Saur³, S. A Gomes⁴, J. M. Hare²
¹Albert Einstein Hospital, São Paulo, Brazil, ²University of Miami, Miami, FL, ³Medizinische Klinik, Technische Universität München, Munich, Germany, ⁴University of São Paulo, São Paulo, Brazil
*Purpose: We recently reported that c-Kit cells isolated from developing kidneys exhibit regenerative potential in mouse models of acute nephrotic syndrome and ischemia-reperfusion injury. These…
2019 American Transplant Congress
Exendin-4 for Donor Treatment in a Brain-Death Model of Kidney Transplantation
H. Yang¹, L. Luo¹, X. Li¹, C. Long¹, Y. Shi², Y. Xiong³, M. Chen⁴, J. Gao⁵, H. Li⁶, Z. Wang⁶
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, ⁵Department of Vascular Surgery, People's hospital of Jiangxi Province, Nanchang, China, ⁶Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Renal grafts from brain death donors associated with poorer graft outcomes after kidney transplantation, hemodynamic and inflammatory mechanisms can account for brain death induce…

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