Articles tagged "Renal injury"

2019 American Transplant Congress
Cyclo (his-pro) Protects Against Gentamicin Induced Cell Apoptosis And Cisplatin Induced Acute Kidney Injury Through Inhibiting P53 Mediated Apoptotic Pathway.
Y. Kim¹, J. Moon¹, J. Jeong¹, J. Kim¹, S. Lee¹, M. Yu², C. Lee³, Y. Kim¹, S. Yang⁴
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, ³Internal Medicine, Cheju Halla General Hospital, Cheju, Korea, Republic of, ⁴Kidney Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Cyclo(His-Pro) (CHP) is an endogenous cyclic dipeptide that exerts cellular protective effects against anti-oxdative damages. However, the role and mechanisms for CHP in preventing…
2019 American Transplant Congress
NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice
D. Choi¹, J. Hwang², J. Jeong³, K. Lee¹, K. Na¹, Y. Ham¹, J. Jeon¹, H. Kim¹, Y. Chang¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, ³Medical Science, Chungnam National University, Daejeon, Korea, Republic of
*Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
2019 American Transplant Congress
Biomarkers in Multivisceral and Intestinal Transplantation
D. A. Cheung¹, J. Garcia¹, T. Beduschi², A. H. Langshaw¹, K. L. Arheart³, I. A. Gonzalez⁴
¹Pediatric Gastroenterology, University of Miami, Miami, FL, ²Surgery, Division of Liver/GI Transplant, University of Miami, Miami, FL, ³Public Health Sciences, Division of Biostatistics, University of Miami, Miami, FL, ⁴Pediatric Infectious Diseases and Immunology, University of Miami, Miami, FL
*Purpose: Multivisceral transplant (MVT) and isolated intestinal transplant (ITx) are complex surgical procedures that result in a pro-inflammatory state, making interpretation of biomarkers in the…
2019 American Transplant Congress
Reverse Signaling through CD137 Ligand Promotes Tissue Repair after Ischemia-Reperfusion Kidney Injury
H. R. Cho¹, S. Lee², J. S. Lee³, S. J. Park¹, B. Kwon²
¹Ulsan University Hospital, Ulsan, Korea, Republic of, ²Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ³Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of
*Purpose: We previously showed that CD137 ligand (CD137L) reverse signaling play a central role in kidney ischemia-reperfusion injury (IRI) by amplifying acute renal injury. In…
2019 American Transplant Congress
Blood Profiling Reflects a Significant Down-Regulation in Oxidative Phosphorylation Following Renal Transplantation with DCD and AKI Allografts
S. Walker¹, L. Cox², C. Langefeld², B. Freedman², A. Farney², J. Rogers², C. Jay², R. Stratta², G. Orlando²
¹Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, ²Wake Forest Baptist Medical Center, Winston Salem, NC
*Purpose: The human kidney transplant (KT) patient provides a unique and compelling in situ model system to study molecular events that underlie graft recovery following…
2019 American Transplant Congress
Kidney-Intrinsic Innate Immunity and Endoplasmic Reticulum Stress Pathways are Key Determinants of Severity of Ischemia-Reperfusion Injury Following Transplantation
L. Qiu¹, J. Wang¹, X. Yeap¹, C. Lin¹, Y. S. Kanwar², D. Fang², M. M. Abecassis¹, Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Ischemia-reperfusion injury (IRI) following kidney transplantation (KTx) frequently leads to delayed graft function and is detrimental to graft longevity. Causes and susceptibilities of KTx…
2019 American Transplant Congress
Effects of Pretreated Bortezomib on Renal Function after Renal Ischemia – Reperfusion Injury in Mice
X. Zheng
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: To observe the effects of pretreated bortezomib at different points on renal function and renal histology after renal ischemia-reperfusion injury in mice.*Methods: A mice…
2019 American Transplant Congress
Elevated Urinary Injury Biomarkers in Deceased Donors Are Not Associated with Long-Term Kidney Transplant Outcomes
N. Koyawala, I. E. Hall, Y. Jia, S. G. Mansour, P. P. Reese, H. R. Thiessen-Philbrook, E. Akalin, J. S. Bromberg, M. D. Doshi, M. N. Harhay, S. Mohan, T. Muthukumar, B. Schroppel, P. Singh, F. L. Weng, C. R. Parikh
DDS Consortium, Baltimore, MD
*Purpose: In the United States, over 90,000 people are on the kidney transplant waiting list and could benefit from more donor organs. Kidneys from deceased-donors…
2019 American Transplant Congress
Donor Derived Cell Free DNA (dd-cfDNA) May Aid in the Diagnosis of BK Virus Nephropathy
D. Brennan¹, J. Bromberg², J. Yee³, S. Dholakia³, M. Haas⁴
¹Johns Hopkins, Baltimore, MD, ²University of Maryland School of Medicine, Baltimore, MD, ³CareDx, Brisbane, CA, ⁴Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Between 10% and 30% of renal transplant recipients (KTR) develop BK viremia; with 1-10% of KTR developing BK virus associated nephropathy (BKVAN), accounting for…
2019 American Transplant Congress
Treprostinil Attenuates Renal Ischemia-Reperfusion Injury in Rat
M. Ding¹, E. Tolbert², M. Birkenbach³, C. Chung⁴, R. Gohh⁵, F. Akhlaghi¹, N. Ghonem¹
¹Biomedical and Pharmaceutical Sciences, URI, Kingston, RI, ²Nephrology, Rhode Island Hsopital, Providence, RI, ³Pathology, Rhode Island Hospital, Providence, RI, ⁴Surgery, Rhode Island Hospital, Providence, RI, ⁵Organ Transplantation, Rhode Island Hospital, Brown University, KINGSTON, RI
*Purpose: Kidney transplantation (KTx) is the optimal treatment for end-stage renal diseases. The surgical procedure of KTx inherently requires cold ischemic preservation and warm reperfusion…

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