Articles tagged "Renal injury"

2015 American Transplant Congress
Post-Transplant Changes in Serum Creatinine and Beta-2 Microglobulin Predict Acute Tubular Necrosis in the Early Post-Transplant Period
P. Liu,¹ A. Djamali,^1,2 D. Kaufman,^2,1 B. Astor.¹
¹Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Purpose: To evaluate the utility of early post-transplant changes in serum creatinine (SCr) and beta-2 microglobulin (B2M) in differentiating acute tubular necrosis (ATN) and other…
2015 American Transplant Congress
Role of Complement in Mediating Pericyte Trans-Differentiation in Resident Myofibroblasts: A New Hypothesis On Vascular Rarefaction in Renal Ischemia/Reperfusion (I/R) Injury
G. Castellano,¹ R. Franzin,¹ C. Divella,¹ A. Stasi,¹ A. Intini,¹ M. Gigante,¹ G. Lucarelli,¹ P. Ditonno,¹ M. Battaglia,¹ A. Crovace,¹ F. Staffieri,¹ G. Pertosa,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹
¹University of Bari, Bari, Italy; ²Pharming Technologies NV, Leiden, Netherlands; ³University of Foggia, Foggia, Italy.
Vascular rarefaction is critical in the development of renal fibrosis. Pericytes regulate renal blood flow and might be an important source of renal interstitial myofibroblasts;…
2015 American Transplant Congress
Acute Kidney Injury in the Early Post Kidney Transplant Period: Frequency, Etiology and Significance
B. Kiberd,¹ S. Cimen,¹ K. Tennankore.²
¹Surgery, Dalhousie University, Halifax, NS, Canada; ²Medicine, Dalhousie University, Halifax, NS, Canada.
Acute kidney injury (AKI) post kidney transplant has not been well described using current diagnostic criteria. The frequency and etiology of AKI in the first…
2015 American Transplant Congress
Mitochondrial Hydrogen Sulphide Donor Molecules Are More Effective Against Hypoxic Injury in Renal Tubular Epithelial Cells
G. Aboalsamh,^1,5 M. Saha,² I. Lobb,² J. Grewal,² P. Luke,^1,2,3 M. Wood,⁴ M. Whiteman,⁴ A. Sener.^1,2,3
¹Urology, University of Western Ontario, London, Canada; ²Microbiology and Immunology, University of Western Ontario, London, Canada; ³University of Western Ontario, University of Western Ontario, London, Canada; ⁴Experimental Therapeutics, University of Exeter Medical School, Exeter, England, United Kingdom; ⁵Surgery, King Abdulaziz Medical Center, Jeddah, Saudi Arabia.
Introduction: Ischemia reperfusion injury (IRI) in organ transplant often manifests itself as delayed graft function (DGF). DGF is associated with increased morbidity and deleterious effects…
2015 American Transplant Congress
Proximal Tubular Dysfunction Is Common After the First Year of Kidney Transplantation
G. Ensergueix,¹ J. Allard,¹ F. Saint-Marcoux,² B. Marin,³ S. Bodeau,² J.-C. Aldigier,¹ P. Marquet,² M. Essig.¹
¹Nephrology, Dialysis, Transplantation, University Hospital, Limoges, France; ²Pharmacology, Toxicology, University Hospital, Limoges, France; ³Epidemiology, Biostatistics, Methodology, University Hospital, Limoges, France.
Background: After the initial period of kidney transplantation, the prevalence of proximal tubular dysfunction (PTD) and its consequences are unknown. The aim of this study…
2015 American Transplant Congress
Acute Kidney Injury and Outcome After Cardiac Transplantation
G. Fortrie,¹ O. Manintveld,² K. Caliskan,² M. Betjes.¹
¹Internal Medicine, Div. of Nephrology, Erasmus Medical Center, Rotterdam, Netherlands; ²Cardiology, Erasmus Medical Center, Rotterdam, Netherlands.
Background:Chronic kidney disease (CKD) is a frequently seen complication after cardiac transplantation and is partly explained by the prolonged use of calcineurin inhibitors. However, few…
2015 American Transplant Congress
Is the Pulsatile Kidney Preservation Machine a Vaulable Tool in Evaluating Kidney Suitability from Older Donors After Brain Death?
D. Paredes Zapata,¹ A. Ruiz Arranz,¹ C. Rodriguez Villar,¹ L. Peri Cussi,² A. Alcaraz Asensio,² R. Adalia Bartolome,¹ F. Oppenheimer Salinas.³
¹Donation and Transplant Coordination Section, Hospital Clinic, University of Barcelona, Barcelona, Spain; ²Urology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain; ³Renal Transplant Unit, Hospital Clinic, Barcelona, Spain.
Introduction: Donors after Brain Death (DBD) older than 60 years old, have become 46.8% of our donor activity, with higher Discard Rate (DR). Assessment of…