ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Renal injury"

  • 2015 American Transplant Congress

    Molecular Classifiers Accurately Measure the Degree of Fibrosis in Human Kidney Transplant Biopsies

    J. Venner, J. Reeve, P. Halloran.

    University of Alberta, Edmonton, Canada.

    Irreversible injury in organ transplants is an important clinical parameter, and is estimated by histology as the observed “ci” lesion, but with considerable inter-observer variability…
  • 2015 American Transplant Congress

    Surgical Error: A Common, Preventable Threat to Deceased Donor Organs

    A. Friedman,1 T. Diflo,2 S. Florman,3 L. Ratner,4 E. Marquez,1 W. Tajik.1

    1New York Organ Donor Network, New York, NY; 2Westchester Medical Center, Valhalla, NY; 3Mount Sinai School of Medicine, New York, NY; 4Columbia Presbyterian Medical Center, New York, NY.

    Deceased donor procurements (N = 340) performed through a single organ procurement organization during a 19 month period from 7/1/13 - 11/30/14 were reviewed through…
  • 2015 American Transplant Congress

    Acute Kidney Injury After Lung Transplantation – Incidence, Risk Factors and Mechanisms

    F. Gueler,1 G. Warnecke,5 M. Peperhove,2 M.-S. Jang,1 C. Schroeder,3 S. Tewes,2 B. Wiese,6 C. Fegbeutel,5 R. Lichtinghagen,7 B. Jüttner,8 F. Wacker,2 D. Hartung,2 B. Akerstrom,4 M. Gram,4 H. Haller,1 A. Haverich,9 K. Hueper.2

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Radiology, Hannover Medical School, Hannover, Germany; 3Proteomics, German Research Cancer Center, Heidelberg, Germany; 4Physiology, Lund University, Lund, Sweden; 5Thoracic and Cardiac Surgery, Hannover Medical School, Hannover, Germany; 6Medical Statistics, Hannover Medical School, Hannover, Germany; 7Laboratory Medicine, Hannover Medical School, Hannover, Germany; 8Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany; 9Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany.

    Background: Acute kidney injury (AKI) is a frequent and severe complication after solid organ transplantation. In a retrospective analysis and afterwards in a prospective clinical…
  • 2015 American Transplant Congress

    Renal Tubular Dysfunction Following Donor Nephrectomy and Its Impact On Residual Kidney Function

    Z. Ahmed,1 C. Rooney,3 C. Turner,2 N. Dalton,2 N. Kessaris,1 N. Mamode.1

    1Renal and Pancreatic Transplantation, Guy's Hospital, London, United Kingdom; 2Wellchild Laboratory, St Thomas' Hospital, London, United Kingdom; 3Faculty of Medicine, King's College London, London, United Kingdom.

    Background: Recent publications have described an increasing incidence of end stage renal disease amongst kidney donors. This highlights the paucity of knowledge which exists in…
  • 2015 American Transplant Congress

    Prospective Measurement of Plasma Neutrophil Gelatinase-Associated Lipoprotein in Living Kidney Donors

    Y. Yoon,1 K. Choi,2 D. Joo,3 K. Huh,3 M. Kim,3 S. Kim,3 Y. Kim,3 S. Yang,2 W. Han.1

    1Department of Urology, Yonsei University College of Medicine, Seoul, Korea; 2Department of Urology, CHA University, Seongnam-si, Korea; 3Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea.

    Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for acute kidney injury. This study was conducted to determine the clinical implications of perioperative plasma NGAL…
  • 2015 American Transplant Congress

    The Molecular Landscape of Atrophy-Fibrosis in Human Kidney Transplants: The Dominant Role of Acute Parenchymal Injury

    J. Venner, P. Halloran.

    University of Alberta, Edmonton, Canada.

    We studied the effect of time post-transplant on atrophy-fibrosis (AF) and molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days to…
  • 2015 American Transplant Congress

    Molecular Marker Strategies Supporting the Novartis US92 Study- A Discovery Study of Protein Biomarkers for Kidney Function (eGFR) and Acute Rejection in Serum from Renal Transplant Patients

    U. Christians,1 J. Klepacki,1 A. Karimpour-fard,1 G. Ingle,2 D. Patel,2 K. Johnson,3 D. Cibrik,3 J. Klawitter.1

    1University of Colorado, Anschutz Medical Campus, Aurora, CO; 2Novartis Pharmaceuticals, East Hanover, NJ; 3University of Michigan Medical School, Ann Arbor, MI.

    Purpose. Protein biomarkers have the potential to allow for earlier and more specific diagnosis of kidney injury in kidney transplant patients than established clinical markers…
  • 2015 American Transplant Congress

    Clinical and Immunological Update 15 Years After the First VCA – Subsequent Kidney Transplantation After a Bilateral Hand Transplant

    A. Weissenbacher,1 G. Pierer,2 M. Gabl,3 M. Ninkovic,1 T. Hautz,1 J. Grahammer,1 B. Zelger,4 B. Zelger,5 G. Brandacher,6 S. Schneeberger.1

    1Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria; 2Department of Plastic, Reconstructive and Aesthetic Surgery, Innsbruck Medical University, Innsbruck, Austria; 3Department of Traumatology, Innsbruck Medical University, Innsbruck, Austria; 4Department of Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria; 5Institute of Pathology, Innsbruck Medical University, Innsbruck, Austria; 6Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

    Background: We herein describe the long term outcome with emphasis on function, immunosuppression (IS), complication and side effects, histomorphology and graft vascular changes 15 years…
  • 2015 American Transplant Congress

    Associations Between Deceased-Donor Urine Biomarkers of Kidney Injury and 6-Month Kidney Transplant Function

    C. Parikh, I. Hall, M. Doshi, B. Schroppel, F. Weng, R. Hasz, P. Murray, V. Rao, H. Thiessen-Philbrook, J. Ficek, P. Reese.

    TRIBE-AKI Consortium, New Haven, CT.

    Assessment of organ quality is integral to allocation, yet existing tools have a limited ability to predict important transplant outcomes. We evaluated whether injury biomarkers,…
  • 2015 American Transplant Congress

    Molecular Correlates of Atrophy-Fibrosis in Human Kidney Transplants Provides a New Model of Renal Fibrosis

    J. Venner, K. Famulski, P. Halloran.

    University of Alberta, Edmonton, Canada.

    We studied the effect of time post-transplant on atrophy-fibrosis (AF) and the molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days…
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