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Articles tagged "Renal function"

  • 2015 American Transplant Congress

    Implications of Living Donor Kidney Histology, Volume and Function on Post-Donation GFR

    Z. Zaky,1 B. Lankowsky,2 S. Shah,1 L. Herlitz,1 A. Chiesa-Vottero,1 K. Wallenfelsz,1 A. Caplin,1 D. Goldfarb,1 S. Flechner,1 J. Schold,1 E. Poggio.1

    1Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH; 2CWRU School of Medicine, Cleveland, OH.

    Living kidney donor transplantation is the best modality for treating ESRD as it confers excellent outcomes to patients and it is safe for donors. Postdonation…
  • 2015 American Transplant Congress

    Comparison of Efficacy and Renal Function in KidneyTransplant Recipients Receiving Tacrolimus (TAC)-Based Immunosuppressive Regimens in Combination With Everolimus (EVR) or Mycophenolate (MPA)

    A. Ferreira,1 C. Felipe,1 P. Ueno,1 P. Hannun,1 P. Ruppel,1 T. Sandes-Freitas,1 H. Proença,3 J. Medina- Pestana,1 H. Tedesco-Silva.1

    1Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; 2Pathology, UNIFESP, Sao Paulo, Brazil.

    Introduction: Acute rejection and renal function are associated with long-term renal allograft survival. We evaluated these outcomes in patients receiving reduced TAC exposure combined with…
  • 2015 American Transplant Congress

    Final Results from the BENEFIT-EXT Trial: A 7 Year Follow-Up of Belatacept Treated Patients

    S. Florman,1 J. Medina Pestana,2 M. Rial,3 L. Rostaing,4 D. Kuypers,5 F. Mühlbacher,6 M. Polinsky,7 U. Meier-Kriesche,7 J. Grinyó,8 A. Durrbach.9

    1Mt Sinai Med Ctr, NY; 2Hosp do Rim e Hipertensão, Sao Paulo, Brazil; 3Inst de Nefrologia, Buenos Aires, Argentina; 4Univ Hospital, Toulouse, France; 5Univ Hospital Leuven, Leuven, Belgium; 6Vienna Transplantation Ctr, Vienna, Austria; 7BMS, Lawrenceville; 8Univ Hosp Bellvitge, Barcelona, Spain; 9Univ Hosp of Bicêtre, Villejuif, France.

    Background: At 3 and 5yrs post-transplant, BENEFIT-EXT showed a renal function benefit and consistent safety in belatacept (bela) treated pts vs cyclosporine (CsA). Final 7…
  • 2015 American Transplant Congress

    Superior Renal Function in an Everolimus-Based Calcineurin Inhibitor Free Regimen Compared to Standard Cyclosporine/Mycophenolate and Low Cyclosporine/Everolimus: Follow-Up of the HERAKLES Study at Month 48

    K. Budde,1 C. Sommerer,1 P. Weithofer,1 O. Witzke,1 M. Guba,1 J. Jacobi,1 B. Vogt,3 I. Hauser,1 R. Stahl,1 P. Reinke,1 T. Rath,1 D. Baeumer,2 M. Porstner,2 M. Zeier,1 F. Lehner,1 W. Arns.1

    1Herakles Study Group, Germany; 2Novartis, Pharma, Germany; 3Herakles Study Group, Switzerland.

    Aim: To follow up on renal function (GFR) at month (Mo) 48 after kidney transplantation (Tx) in patients (pts) on immunosuppressive regimen with different calcineurin…
  • 2015 American Transplant Congress

    Belatacept-Treated Patients Had Better Graft Survival at 7-Years Post-Transplant Compared With Cyclosporine-Treated Patients: Final Results from BENEFIT

    F. Vincenti,1 J. Grinyó,2 L. Rostaing,3 K. Rice,4 S. Steinberg,5 M. Moal,6 M. Polinsky,7 U. Meier-Kriesche,7 C. Larsen.8

    1Univ of Calif, San Francisco; 2Univ Hosp Bellvitge, Barcelona, Spain; 3Univ Hosp and INSERM U563,IFR-BMT, Toulouse, France; 4Baylor Univ Med Ctr, Dallas; 5Sharp Memorial Hosp, San Diego; 6Hôp de La Cavale Blanche, Brest, France; 7BMS, Lawrenceville; 8Emory Univ Transpl Ctr, Atlanta.

    Background: At 3yrs, improvement in renal function was seen in kidney transplant recipients treated with belatacept (bela) vs cyclosporine (CsA) in BENEFIT. Here we report…
  • 2015 American Transplant Congress

    mTOR-Based CNI Minimization Vs Withdrawal in African American Kidney Transplant Recipients

    J. Fleming,1 D. Taber,2 N. Pilch,1 H. Meadows,1 C. Mardis,1 J. McGillicuddy,2 S. Nadig,2 K. Chavin,2 P. Baliga,2 C. Bratton.2

    1Pharmacy, Medical University of South Carolina, Charleston, SC; 2Surgery, Medical University of South Carolina, Charleston, SC.

    The purpose of this study was to compare mTOR-based CNI withdrawal vs. minimization in African American (AA) kidney transplant (KTx) recipients.METHODS: This was a single-center,…
  • 2015 American Transplant Congress

    Impact of Proton Pomp Inhibitors on Hypomagnesemia and Arterial Stiffness in Renal Transplant Recipients

    S. Sezer,1 B. Gurlek Demirci,1 M. Erkmen Uyar,1 S. Uyanik,2 M. Haberal.3

    1Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey; 2Department of Intrenal Medicine, Baskent University Faculty of Medicine, Ankara, Turkey; 3Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.

    Purpose: Hypomagnesemia predicts cardiovascular morbidity and mortality in the general population and accelerated loss of kidney function in renal transplant recipients (RTRs). Proton pomp inhibitors…
  • 2015 American Transplant Congress

    Month 48 Follow-Up Results of HERAKLES Trial on Three Different Treatment Regimen and Switching Off Behaviour in De Novo Renal Transplant Patients

    W. Arns,1 K. Budde,1 C. Sommerer,1 O. Witzke,1 M. Guba,1 J. Jacobi,1 B. Vogt,3 P. Reinke,1 I. Hauser,1 R. Stahl,1 T. Rath,1 D. Baeumer,2 M. Porstner,2 M. Zeier,1 F. Lehner,1 V. Kliem.1

    1Herakles Study Group, Germany; 2Novartis, Pharma, Germany; 3Herakles Study Group, Switzerland.

    Aim: To compare switching off 3 different immunosuppressive (IS) regimen 4years after renal transplantation (Tx).Methods: 802 patients (pts) were included in this prospective, open-label, randomized,…
  • 2015 American Transplant Congress

    Pharmacist-Led Renal-Sparing Conversion to Everolimus After Liver Transplantation

    T. Horwedel,1 L. Bowman,1 W. Chapman,2 J. Hagopian.1

    1Barnes-Jewish Hospital, St. Louis, MO; 2Washington University in St. Louis, St. Louis, MO.

    Purpose: Preservation of renal function following orthotopic liver transplantation (OLT) through calcineurin inhibitor (CNI)-minimization is an established clinical objective. The use of everolimus (EVR) to…
  • 2015 American Transplant Congress

    A 52-Week, Multicenter, Prospective, Observational, Non-Interventional, Open-Label Study to Assess the Effectiveness, Safety and Tolerability of Everolimus in Kidney Transplant Patients in Taiwan

    S.-M. Wang,1 P.-C. Lee,2 J.-D. Lian,3 K.-H. Shu,4 S.-T. Wu,5 H.-C. Chen,6 C.-C. Huang,7 M.-S. Wu,8 Y.-C. Tian,9 Y.-J. Chiang,10 Y.-T. Chen,11 H.-P. Wang.12

    1National Taiwan University Hospital, Taipei, Taiwan; 2National Cheng Kung University Hospital, Tainan, Taiwan; 3Chung Shan Medical University Hospital, Taichung, Taiwan; 4Taichung Veteran's General Hospital, Taichung, Taiwan; 5TriService General Hospital, Taipei, Taiwan; 6Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 7China Medical University Hospital, Taichung, Taiwan; 8Taipei Medical University Hospital, Taipei, Taiwan; 9ChangGung Memorial Hospital–Taipei, Taipei, Taiwan; 10ChangGung Memorial Hospital–LinKou, Taoyuan, Taiwan; 11ChangGung Memorial Hospital-Kaohsiung, Kaohsiung, Taiwan; 12E-Da Hospital, Kaohsiung, Taiwan.

    The study aimed to assess the clinical safety and tolerability of everolimus (EVR) in Taiwan kidney transplant patients.This study enrolled 203 kidney transplant recipients, between…
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