2015 American Transplant Congress
Change in Frailty Status Over Time Among In-Center Hemodialysis ESRD Patients in the ACTIVE/ ADIPOSE Study
Emory University, Atlanta, GA.
Introduction: Frailty among End Stage Renal Disease (ESRD) is associated with poor health outcomes, including delayed graft function and hospitalization following transplantation. Although frailty is…2015 American Transplant Congress
Outcome of Renal Sparing Protocol in a Cross-Sectional Analysis After Heart Transplant
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Calcineurin inhibitors (CNIs) are the mainstay of immunotherapy after heart transplantation. Unfortunately CNIs are associated with renal dysfunction due to nephrotoxic side effects. The…2015 American Transplant Congress
Urinary Cell-Free DNA Is a Sensitive Marker of Early Renal Transplant Injury
Surgery, UC San Francisco, San Francisco, CA.
Introduction:Circulating donor-derived cell-free DNA (dd-cfDNA) has been reported as a surrogate of transplant injury in the blood but requires expensive donor and recipient DNA sequencing.Method:…2015 American Transplant Congress
Prevalence, Risk Factors, and Clinical Management of Chronic Renal Dysfunction in Heart Transplant Recipients
Background: Chronic kidney disease (CKD) is a frequent complication after heart transplantation. The magnitude of post-transplant CKD makes it necessary to characterize patients at increased…2015 American Transplant Congress
Moderate Rejection Episode of Face Transplant After mTOR Conversion to Preserve Renal Function
1University of Maryland School of Medicine, Baltimore; 2New York Medical University, New York City.
Face and hand vascularized composite allografts (VCA) have demonstrated durable graft survivals with conventional immunosuppression but with the appearance of renal dysfunction. Management strategies that…2015 American Transplant Congress
Six-Month Urinary CCL2 Levels Predict Long-Term Renal Allograft Outcome
Graft loss is a major cause of morbidity and mortality. We have shown that 6-month urine CCL2 is an independent predictor for death-censored graft loss.…2015 American Transplant Congress
Molecular and Functional Immune Assays as Non-Invasive Diagnostic Tools to Assess the Risk of Acute Subclinical Rejection After Kidney Transplantation
Subclinical allograft rejection (sc-AR) is still a main cause of allograft loss that can only be assessed through invasive surveillance biopsies. We sought to investigate…2015 American Transplant Congress
Interstitial Fibrosis Is the Critical Determinant of Impaired Renal Function in Transplant Glomerulopathy
PURPOSE: Transplant glomerulopathy (TGP) represents chronic antibody-mediated injury in the glomerular capillaries after renal transplantation, and is the main cause of graft failure. TGP is…2015 American Transplant Congress
Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia
Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…2015 American Transplant Congress
Morphometry of the Epithelial-Mesenchymal Transition (EMT) in Subsequent Biopsies from Transplanted Kidney
EMT plays the principal role in the pathogenesis of IF/TA as a consequence in the failure of a transplanted kidney. Many facts suggest that the…
American Transplant Congress abstracts