2018 American Transplant Congress
The Combination of pAMR and Circulating Donor-Specific Antibodies is Even More Associated with Cardiac Allograft Vasculopathy after Heart Transplant
Cedars Sinai Medical Center, Los Angeles.
Purpose: Several reports have correlated the development of donor-specific antibody (DSA) to the development of cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). Interestingly, patients…2018 American Transplant Congress
Analysis of Rabbit Anti-Thymocyte Globulin versus Basiliximab Induction in Pediatric Liver Transplant Recipients
Background: Literature is limited comparing rabbit anti-thymocyte globulin (rATG) versus basiliximab (BSX) induction in pediatric liver transplant (LT) recipients in the setting of modern-day maintenance…2018 American Transplant Congress
De Novo Donor Specific Antibodies in Pediatric Kidney Transplant Recipients Are Highly Responsive to Therapy
Pediatric Nephrology, Lucile Packard Children´s Hospital, Palo Alto, CA.
Background: Pediatric Kidney transplant recipients who develop dnDSAs are at increased risk of allograft loss and rapid decline in GFR. C1q+ DSA, in particular, is…2018 American Transplant Congress
Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immunoregulatory Molecules Are Present in Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation
Exosomes containing mismatched donor HLA and lung restricted self-antigens (SAgs), Kα1 Tubulin (Kα1T) and Collagen V (Col-V), have demonstrated in sera and bronchoalveolar lavage fluid…2018 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Early Allograft Inflammation: A Prospective Study
University of Pittsburgh Medical Center, Pittsburgh.
The impact of early allograft inflammation is unclear. We prospectively studied changes in renal function and histology in a cohort of patients who received a…2018 American Transplant Congress
Treatment of Post Transplant Hepatitis C (HCV) with Direct-Acting Antiviral (DAA) Agents May Improve Liver Function but Does Not Lead to an Increase in Liver Rejection
Surgery, Hartford Hospital, Hartford, CT.
Previous studies have suggested that with the use of with (DAA) agents to treat post transplant (HCV), there has been an increased incidence of liver…2018 American Transplant Congress
Class II Anti-HLA IgG2 and IgG3 DSAs Predict Poorer Outcomes in Chronic Antibody Mediated Rejection of Renal Allografts
Introduction: whilst the development of IgG3 and C1q binding de novo [dn] HLA DSAs are associated with a poor outcome in acute antibody mediated rejection,…2018 American Transplant Congress
A Follow-Up Report on the Use of IVIG+Rituximab to Reduce Donor Specific Antibodies and Improve Transplant Rates in Highly-Sensitized Patients Awaiting Deceased Donor Kidney Transplantation
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction: Desensitization (DES) with IVIG/rituximab is associated with a reduction in donor specific antibodies (DSA), improved transplant rates and outcomes in highly-sensitized (HS) patients. We…2018 American Transplant Congress
Recipient IFNAR1 Signaling Supports Costimulation Independent Rejection by Promoting T Cell Activation
Department of Surgery, Emory University, Atlanta, GA.
Costimulation blockade (CoB) is a promising strategy for more targeted/less toxic transplant immunosuppression which has led to the first improvement in long-term outcomes for transplant…2018 American Transplant Congress
Association of Leptin with Cystatin C in Kidney Allograft Dysfunction
Background: Non-invasive biomarkers are needed for monitoring recipients of kidney allografts to predict acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft…
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