2018 American Transplant Congress
“Majority Rules”: A Method to Reduce Variability in Diagnosing Antibody Mediated Rejection in Renal Allograft Biopsies Using Banff 2013
1Mayo Clinic, Rochester, MN; 2Mayo Clinic, Scottsdale, AZ; 3Mayo Clinic, Jacksonville, FL.
Introduction: The Banff 2013 criteria for diagnosing antibody-mediated rejection (ABMR) includes three lesions: glomerulitis (g), peritubularitis (PTC), and chronic glomerulopathy (cg). The poor reproducibility of…2018 American Transplant Congress
Donor-Specific Antibody Mediates Chronic, but Not Acute, Kidney Allograft Rejection in the Absence of Natural Killer Cells
Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
The incidence of antibody-mediated kidney graft rejection continues to increase. We previously reported that dysregulated donor-specific antibody (DSA) responses were induced in B6.CCR5-/- mice transplanted…2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…2018 American Transplant Congress
Donor-Derived Cell-Free DNA Outperforms Serum Creatinine Changes for Identifying Kidney Transplant Rejection
Purpose: In the DART study, donor-derived cell-free DNA (dd-cfDNA) discriminated biopsy-based diagnosis of active rejection in kidney transplant patients but serum creatinine (sCr) level did…2018 American Transplant Congress
Early Experience Using Donor-Derived Cell-Free DNA for Detection of Rejection in Kidney Transplantation
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction:Donor-derived cell free DNA (ddDNA; Allosure, CareDX) has been validated as a non-invasive test that can discriminate rejection from non-rejection in kidney transplantation, but has…2018 American Transplant Congress
Impact of Postoperative Serum Chloride Changes on Graft Function and Acute Rejection in Recipients of Living Kidney Transplants
Background: In the non-transplant setting, hyperchloremia has been associated with kidney injury. We sought to study the impact of serum chloride (SCl) on transplant outcomes.Methods:…2018 American Transplant Congress
Regulation of Indoleamine 2,3-Dioxygenase in Porcine Kidney Transplants
1Augusta University, Augusta, GA; 2Gift of Life Michigan, Ann Arbor, MI; 3Norwood VAMC, Augusta, GA.
Indoleamine 2,3-dioxygenase (IDO) is an endogenous immunosuppressant exerting its effects through tryptophan depletion and kynurenine generation. Kynurenine 3-monooxygenase (KMO) is a downstream enzyme from IDO…2018 American Transplant Congress
Cytokine Profiles in Children after Pediatric Kidney Transplantation with Acute and Chronic Rejection
Pediatric Nephrology, Hannover Medical School, Hannover, NDS, Germany.
BackgroundActually, a diagnosis of acute cellular or chronic humoral rejection after pediatric kidney transplantation (pKTX) can only be secured by graft biopsy. Until now, no…2018 American Transplant Congress
Intravenous Immunoglobulins and Methylprednisolone Stabilizes Renal Allograft Function in the Majority of Patients with C-aABMR
Erasmus Medical Center, Rotterdam, Netherlands.
BackgroundChronic active antibody mediated rejection (c-aABMR) leads to progressive decline in allograft function and is a major contributor to long-term kidney allograft loss. To date,…2018 American Transplant Congress
The Impact of Lymphocele Formation after Kidney Transplantation on De Novo Donor Specific Antibody Formation
Introduction: Lymphocele formation is a common complication after kidney transplantation and has been linked to rejection episodes. However, long-term outcome data are scarce and the…
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