Articles tagged "Rejection"

2018 American Transplant Congress
Reliability of Bronchiolitis Obliterans Syndrome Reporting to the OPTN
R. Carrico,¹ R. Lehman,¹ K. Uccellini,¹ K. Chan,² T. Whelan.³
¹United Network for Organ Sharing, Richmond; ²Univ of Michigan, Ann Arbor; ³Medical Univ of South Carolina, Charleston.
Background: Chronic rejection of the lung allograft is traditionally classified as bronchiolitis obliterans syndrome (BOS) diagnosed by obstructive airway physiology. The OPTN requires the reporting…
2018 American Transplant Congress
Reduced Ratio of FoxP3/ RORγt Gene Expression, in Peripheral Blood, is Associated with Acute Allograft Rejection in Recipients with Kidney Transplantation
R. Dhital,^1,2 R. Minz,³ M. Minz,^1,4 A. Sharma,¹ R. Nada,⁵ S. Singh,¹ D. Kenwar,¹ S. Anand.³
¹Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, UT, India; ²Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH; ³Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, UT, India; ⁴Organ Transplantation, Fortis Hospital, Mohali, Punjab, India; ⁵Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, UT, India.
Introduction:FoxP3 has been well established as an indispensable protein that is required in the development and function of regulatory T cells. On the other hand,…
2018 American Transplant Congress
Investigation of Lower Treatment Failure Rate Seen among Black Kidney Recipients on LCP-Tacrolimus vs. IR-Tacrolimus: Subgroup Analyses of Two Phase 3 Trials
T. Sparkes,¹ B. Masters,¹ C. Staino,² S. Patel,² M. Cooper.³
¹University of Maryland, Baltimore, MD; ²Veloxis, Cary, NC; ³Medstar Georgetown Transplant Institute, Washington, DC.
Black kidney transplant recipients are recognized as high risk for inferior allograft survival due to immunologic and non-immunologic factors. Pooled data from 2 Phase 3…
2018 American Transplant Congress
Extended Experience Using Tocilizumab (Anti-IL6R, TCZ) for the Treatment of Chronic Antibody Mediated Rejection (CABMR)
J. Choi,¹ O. Aubert,² S. Louie,¹ N. Ammerman,¹ A. Vo,¹ A. Peng,¹ E. Huang,¹ R. Najjar,¹ D. Puliyanda,¹ S. Sethi,¹ M. Haas,¹ K. Lim,¹ A. Loupy,² S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Paris Translational Center for Organ Transplantation, Paris, France.
Introduction: Disruption of the IL-6/IL-6R pathways may have benefits in treating allograft rejection. We reported our experience with anti-IL-6R (TCZ) as a treatment for CABMR…
2018 American Transplant Congress
Effect of Acute Vascular Inflammation (v) on Death Censored Graft Failure (DCGF) Following Kidney Transplant (KTx)
J. Grande,¹ L. Hunsicker,² R. LeDuc,³ A. Matas, The DeKAF Consortium.
¹Pathology, Mayo Clinic, Rochester, MN; ²Int. Med., U Iowa, Iowa City, IA; ³Biostatistics and Surgery, U Minnesota, Minneapolis, MN.
The impact of acute vascular inflammation in acute cellular or humoral rejection following KTx, and the effect of isolated vascular inflammatory lesions on late DCGF,…
2018 American Transplant Congress
Diagnostic Value and Confounding Factors of Urinary Biomarkers in the Non-Invasive Screening of Renal Allograft Inflammation
A. Vermorel,¹ A. Devresse,¹ C. Tinel,^1,2 V. Sauvaget,² L. Morin,² L. Amrouche,^1,2 M. Rabant,^2,3 D. Anglicheau.^1,2
¹Renal Transplantation Unit, Necker-Enfants Malades Hospital, Paris, France; ²INSERM U1173, Institut Necker Enfants Malades, Paris, France; ³Pathology, Necker-Enfants Malades Hospital, Paris, France.
IntroductionThe value of urinary biomarkers has already been demonstrated in diagnosing acute rejection of the renal allograft, but confounding factors, which may interfere with their…
2018 American Transplant Congress
Elucidating Novel Signatures of Allograft Rejection through Cytometry by Time of Flight (CyTOF) in Kidney Transplant Recipients
S. Eskandari,¹ B. Al Dulaijan,¹ J. Assaker,¹ L. Riella,¹ A. Kurdi,² J. Azzi.¹
¹Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
Mass cytometry by time-of-flight (CyTOF) permits the simultaneous assessment of over 40 functional and phenotypic parameters at the single-cell level. This novel tool holds tremendous…
2018 American Transplant Congress
Repeat Kidney Transplant Patients with Active Rejection Have Elevated Donor-Derived Cell-Free DNA
S. Mehta,¹ J. Chang,² T. Hailey,¹ D. Hiller,³ M. Grskovic,³ J. Yee,³ R. Mannon.¹
¹University of Alabama School of Medicine, Birmingham, AL; ²Columbia University Medical Center, New York, NY; ³CareDx, Brisbane, CA.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is an established marker of active rejection in de novo kidney transplant recipients. Here we characterize dd-cfDNA in patients who…
2018 American Transplant Congress
Interstitial Inflammation is Correlated with DQ Antibodies in Kidney Transplant Recipients
C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.
Icahn School of Medicine at Mount Sinai, New York.
Background: Studies have shown that borderline rejection (BR) and acute cellular rejection (ACR) often co-occur with antibody-mediated rejection (AMR). We examined the association between interstitial…
2018 American Transplant Congress
Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates
H. Sasaki,¹ C. Thaiss,¹ T. Oura,¹ A. Rosales,² R. Smith,² R. Colvin,² B. Cosimi,¹ T. Kawai.¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston; ²Pathology, Massachusetts General Hospital, Boston.
Background: We have previously reported long-term renal allograft tolerance after induction of transient mixed chimerism in non-human primates. However, some recipients developed late onset chronic…