Articles tagged "Rejection"

2018 American Transplant Congress
Serial Monitoring of Resolution of Sub-Clinical Acute Rejection (subAR) in Kidney Transplant Recipients (KTR) Using a Gene Expression Profile (GEP)
L. Zhao,¹ B. Armstrong,² J. Friedewald,¹ T. Whisenant,³ S. Kurian,³ R. Heilman,⁴ E. Poggio,⁵ C. Marsh,³ P. Baliga,⁶ N. Bridges,⁷ J. Odim,⁷ M. Brown,⁷ D. Ikle,² J. Charette,¹ S. Brietigam,¹ N. Sustento-Reodica,¹ M. Kandpal,¹ D. Salomon,³ M. Abecassis.¹
¹Northwestern, Chicago; ²Rho, Chapel Hill; ³Scripps, La Jolla; ⁴Mayo AZ, Scottsdale; ⁵Cleveland Clinic, Cleveland; ⁶MUSC, Charleston; ⁷NIAID, Bethesda.
BACKGROUNDSubAR can currently only be detected using surveillance biopsies (SBx) and is associated with poor long-term graft outcomes. Response to treatment is difficult to assess.…
2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…
2018 American Transplant Congress
Diagnostic Usefulness of Medullary C4d Staining in Renal Allografts
J. Von Visger,¹ C. Von Visger, A. Satoskar,² T. Nadasdy,² J. Hemminger,² S. Brodsky.²
¹Medicine, The Ohio State University Wexner Medical Center, Columbus, OH; ²Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
Background: Detection of peritubular capillary (PTC) complement C4d on renal allograft biopsy is a histologic marker (along with serum anti-donor antibody, PTC inflammatory cells and…
2018 American Transplant Congress
How Should Pancreas Transplant Rejection Be Treated?
F. Aziz, S. Parajuli, S. Salahuddin, K. Harrold, A. Djamali, B. Astor, J. Odorico, D. Mandelbrot.
Department of Nephrology, University of Wisconsin, Madison.
How Should Pancreas Transplant Rejection be Treated?Background: There is limited information about how to approach the treatment of pancreas rejection, particularly regarding the use of…
2018 American Transplant Congress
Improved Mouse Renal Transplantation Model Mimicking Clinical Antibody Mediated Rejection
D. Zhao,¹ T. Liao,¹ S. Li,¹ J. Zhou,² F. Han,¹ Y. Dong,³ Q. Sun.¹
¹Organ Transplantation Institution, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Pathology, Third Affiliated Hospital of Sun Yat-sen University, Guanghzou, Guangdong, China; ³Department of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Antibody mediated rejection (AMR) is main barrier to long term renal graft survival and mouse model is important to understand the mechanisms of AMR and…
2018 American Transplant Congress
Protocol Biopsies after Paediatric Kidney Transplantation: A Single Centres' 17 Year Experience
T. Alsulaimi,¹ M. Aloufi,² S. Grisaru,¹ S. Samuel,¹ L. Hamiwka.¹
¹Paediatric Nephrology, University of Calgary, Calgary, AB, Canada; ²Pediatric Nephrology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
PURPOSE: Standard laboratory measures are not sensitive indicators of kidney dysfunction following transplantation and may be less reliable in paediatric recipients. Early graft surveillance may…
2018 American Transplant Congress
Pre-Transplant versus De Novo Donor Specific Antibodies: Differences in Clinical Outcomes and Antibody Mediated Rejection
M. Ajaimy, N. Hayde, A. Colovai, E. Akalin.
Montefiore-Einstein Transplant Center, Montefiore-Einstein Transplant Center, Bronx.
Background: Antibody mediated rejection (ABMR) can occur through pre-transplant(tx) vs. de novo donor specific antibodies (DSA). Clinical outcomes, allograft injury and dynamics of DSAs have…
2018 American Transplant Congress
Incidence of Rejection and Antibody Formation after Immunosuppression Reduction in Patients with Biopsy Proven Polyomavirus Nephropathy
M. Kleman, R. Detwiler, H. Singh, V. Nickeleit.
University of North Carolina, Chapel Hill, NC.
The purpose of this study is to determine the incidence of rejection and donor specific antibody (DSA) formation after immunosuppression reduction in patients with biopsy…
2018 American Transplant Congress
The Effects of Age-Adjusted Marriage Duration on Graft Outcomes in Spousal Donor Kidney Transplantation
M. Yu,¹ J. Park,² H. Cho,¹ J. Ha,¹ C. Ahn,¹ Y. Kim,¹ H. Lee.¹
¹Seoul National University Hospital, Seoul, Korea; ²Kangwon National University Hospital, Chuncheon, Korea.
It is well known that graft survival rate in spousal donor kidney transplantation (SKT) is similar to that of living related donor kidney transplantation (LRKT)…
2018 American Transplant Congress
Delivery of Culturally-Competent Transplant Care among Hmong Kidney Transplant Recipients: Outcomes from a Single Institution
M. Odegard,¹ O. Serrano,¹ K. Peterson,¹ S. Mongin,² D. Berglund,³ D. Vock,⁴ S. Chinnakotla,¹ T. Dunn,¹ E. Finger,¹ R. Kandaswamy,¹ T. Pruett,¹ A. Matas.¹
¹Division of Transplantation, Division of Surgery, University of Minnesota, Minneapolis, MN; ²Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN; ³Informatics Services for Research and Reporting, Fairview, University of Minnesota, Minneapolis, MN; ⁴Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN.
OBJECTIVE: Kidney transplantation (KT) entails delivery of complex, well-coordinated, multidisciplinary care. Cultural and linguistic discordance among transplant providers and patients can lead to healthcare disparities.…