Articles tagged "Rejection"

2018 American Transplant Congress
Once-Daily Prolonged-Release Tacrolimus versus Twice-Daily Tacrolimus in Liver Transplantation: A Meta-Analysis
R. Deng, B. Huang, Y. Shi, Y. Ma.
Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background: A prolonged-release formulation of tacrolimus has been developed to provide once-daily dosing, with similar efficacy and safety to the standard twice-daily dosing and it…
2018 American Transplant Congress
Early Sub-Clinical and Clinical TCMR Are Associated with Progressive Renal Allograft Dysfunction
A. Cherukuri, D. Chittka, R. Mehta, P. Sood, S. Hariharan.
UPMC, Pittsburgh.
Background: The clinical course and significance of early sub-clinical (SCR) and clinical TCMR (ACR) vs. no rejection (NR) is unclear. In this prospective study, we…
2018 American Transplant Congress
Precision (re)Phenotyping of Histologically Stable Kidney Transplants
D. Rychkov,¹ T. Sigdel,² M. Sirota,¹ M. Sarwal.²
¹Institute for Computational Health Sciences, UCSF, San Francisco, CA; ²Department of Surgery, UCSF, San Francisco, CA.
Background: Acute Rejection (AR) is the main cause of the renal failure within one year after transplantation (tx). Its earlier diagnosis is crucial for a…
2018 American Transplant Congress
Pre-Transplant Assessment of AMR Risk by Novel Donor/recipient Non-HLA Variants
S. Pineda,¹ T. Sigdel,¹ J. Chen,¹ A. Jackson,² M. Sirota,¹ M. Sarwal.¹
¹UCSF, San Francisco; ²Johns Hopkins University, Baltimore.
Transplant (tx) injury from antibody mediated (AMR) and T cell mediated (CMR) rejection, limits indefinite survival after HLA mismatched organ tx. AMR is incompletely diagnosed…
2018 American Transplant Congress
Tocilizumab Stabilizes Renal Function in Kidney Transplant Recipients with Chronic Active Antibody Mediated Rejection (CAAMR)
S. Patel, S. Mohan, H. Fernandez, I. Batal, L. Ratner, J. Crew.
Columbia University, New York.
INTRO: CAAMR after kidney transplantation (KTx) is associated with rates of allograft failure approaching 50% at 2 years from injury involving T cells, B cells,…
2018 American Transplant Congress
Endoplasmic Reticulum Stress Sensor IRE1α Deficiency Promotes Infiltrating Macrophage Polarization and Induces Long-Term Renal Allograft Acceptance in Mice
L. Qiu,¹ J-.J. Wang,¹ X. Yeap,¹ D. Fang,² J. Zhang.¹
¹Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL; ²Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Objective: Macrophage is involved in the pathogenesis of I/R injury and allograft rejection. However, the mechanisms underlying this is vastly unknown. This study aims to…
2018 American Transplant Congress
Intragraft Gene Expression Differentiates Polyomavirus Nephropathy from T-Cell Mediated Rejection
B. Adam,¹ S. Wagner,¹ J. Bräsen,² V. Bröcker,² V. D'Agati,³ C. Drachenberg,⁴ E. Farkash,⁵ A. Farris,⁶ L. Geldenhuys,⁷ A. Magil,⁸ V. Nickeleit,⁹ P. Randhawa,¹⁰ H. Regele,¹¹ M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Hannover Medical School, Hannover, Germany; ³Columbia University, New York; ⁴University of Maryland, College Park; ⁵University of Michigan, Ann Arbor; ⁶Emory University, Atlanta; ⁷Dalhousie University, Halifax, Canada; ⁸University of British Columbia, Vancouver, Canada; ⁹University of North Carolina, Chapel Hill; ¹⁰University of Pittsburgh, Pittsburgh; ¹¹Medical University of Vienna, Vienna, Austria.
Background: Improved immunosuppression protocols have reduced the incidence of T-cell mediated rejection (TCMR) but still carry a significant risk of BK polyomavirus nephropathy (BKVN). Despite…
2018 American Transplant Congress
Bioinformatics Approach to the Development of a Novel Molecular Biomarker for Sub-Clinical Acute Rejection (subAR) in the Peripheral Blood Following Kidney Transplant (KT)
T. Whisenant,¹ S. Kurian,¹ M. Kandpal,² L. Zhao,² D. Ikle,³ B. Armstrong,³ J. Friedewald,² R. Heilman,⁴ E. Poggio,⁵ C. Marsh,¹ P. Baliga,⁶ N. Bridges,⁷ J. Odim,⁷ M. Brown,⁷ J. Charette,² S. Brietigam,² N. Sustento-Reodica,² D. Salomon,¹ M. Abecassis.²
¹Scripps, La Jolla; ²Northwestern, Chicago; ³Rho, Chapel Hill; ⁴Mayo AZ, Scottsdale; ⁵Cleveland Clinic, Cleveland; ⁶MUSC, Charleston; ⁷NIAID, Bethesda.
Sub-clinical acute rejection (subAR) following KT is associated with poor long-term graft outcomes and can only be detected using invasive surveillance biopsies (SBx). Non-invasive biomarker…
2018 American Transplant Congress
Urinary C-X-C Motif Chemokines 13 is a Noninvasive Biomarker of Antibody-Mediated Renal Allograft Rejection
D. Chen, J. Chen.
Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Background: Since acute rejection remains one of the major complications which necessitate periodic surveillance, noninvasive diagnostic/prognostic methods are preferred by renal transplant recipients. Here we…
2018 American Transplant Congress
Impact of Pretransplant Donor-Specific Antibodies on Kidney Allograft Recipients with Negative Flow Cytometry Crossmatches
H. Kwon, Y. Kim, J. Choi, S. Shin, J. Jung, M. Cho, J. Kim, D. Han.
Asan Medical Center, Seoul, Korea.
This study evaluated the impact of DSA on clinical outcomes in KT recipients negative on FCXM. Of 575 consecutive patients who underwent living donor KT…