Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
- Evaluating Associations Between Clinical and Psychosocial Risk Factors and Adverse Post-Transplant Events in High Risk Renal Transplant Recipients.
- Assessment of IgG Subclass Significance for Early Graft Rejection and Long-Term Survival in HLA-Antibody Incompatible Renal Transplantation: Multivariate Approach
Transplant-specific risk factors for rejection are well documented, yet psychosocial variable correlation with rejection risk is not; this analysis seeks to determine the relationship between psychosocial variables and rejection outcomes.
Psychosocial data was collected from pre-transplant evaluation reports for patients transplanted from 2006-2016. Patients without psychosocial records were excluded. A multivariate logistic regression was performed using STATA software with rejection as the dependent variable.
Adequate drug coverage was significant for decreased rejection risk (OR=0.27,p<0.001), while lacking follow up compliance was significant for increased rejection risk (OR= 5.17, p<0.001). Other variables were not statistically significant.
|Adequate Drug Coverage||375(73)||46(46)||0.27||<0.001||0.143-0.49|
|Substance Abuse Suspected||55(11)||14(14)||0.89||0.87||0.21-3.69|
|Lack Routine Labs/ Follow Up||175(34)||69(69)||5.17||<0.001||2.45-10.94|
|1-yr Increase in Age (avg)||49.00||42.76||0.98||0.03||0.96-1.00|
This analysis considers rejection risk in the setting of a multivariate analysis with other known risk factors for rejection. Both protective factors and risk factors were identified, showing that pre-transplant evaluation psychosocial factors impact post-transplant outcomes.
CITATION INFORMATION: Chernobylsky D., Carsky K., McDermott C., Ferrin P., Fernandez R., Gaines I., Killackey M., Zhang R., Paramesh A., Buell J. Impact of Psychosocial Variables on Renal Allograft Rejection Risk: A Multivariate Analysis Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Chernobylsky D, Carsky K, McDermott C, Ferrin P, Fernandez R, Gaines I, Killackey M, Zhang R, Paramesh A, Buell J. Impact of Psychosocial Variables on Renal Allograft Rejection Risk: A Multivariate Analysis [abstract]. https://atcmeetingabstracts.com/abstract/impact-of-psychosocial-variables-on-renal-allograft-rejection-risk-a-multivariate-analysis/. Accessed January 26, 2020.
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