ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2022 American Transplant Congress

    Gene Expression Profiles of Peritubular Capillarits in Chronic Antibody-Mediated Rejection

    M. Eder1, M. Röbl1, H. Omic1, B. Adam2, D. Cejka3, N. Kozakowski4, D. D´Andrea5, M. Mengel2, Ž. Kikić5

    1Internal Medicine III, Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria, 2Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada, 3Department of Medicine III, Nephrology, Hypertension, Transplantation and Rheumatology, Ordensklinikum Linz – Elisabethinen, Linz, Austria, 4Department of Pathology, Medical University of Vienna, Vienna, Austria, 5Department of Urology, Medical University of Vienna, Vienna, Austria

    *Purpose: Antibody-mediated rejection (ABMR) is one of the most significant contributors to late graft loss. Hallmark characteristics include peritubular capillaritis (ptc) and glomerulitis (g). Diffuse…
  • 2022 American Transplant Congress

    Biopsy and Blood Gene Expression Profiles Distinguish Injury, Subclinical and Clinical Rejection in Kidney Transplant Recipients

    S. Kurian1, M. Kandpal2, C. Rebello2, C. Marsh1, J. Friedewald2

    1Scripps Health, La Jolla, CA, 2Northwestern University, Chicago, IL

    *Purpose: We analyzed serial gene expression profiles in paired blood and biopsies from kidney transplant recipients phenotyped with a comprehensive clinical algorithm. We compared disease…
  • 2022 American Transplant Congress

    Influence of Converting Kidney Transplant Recipients with High Tacrolimus Variability to the Once Daily LCP Tac Formulation

    D. Taber, F. Bartlett, N. Patel, T. Sprague, S. Patel, J. Newman, E. Andrade, N. Rao, A. Posadas, V. Rao, M. Casey, D. Dubay, V. Rohan

    Med Univ of South Carolina, Charleston, SC

    *Purpose: Tacrolimus (Tac) is the cornerstone of immunosuppression used in kidney transplant recipients (KTRs). Tac high variability, low time in therapeutic range and non-adherence are…
  • 2022 American Transplant Congress

    Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)

    M. R. Weir1, D. Mandelbrot2, J. S. Bromberg1, S. Mehta3, E. Poggio4, E. Huang5, G. Shekhtman6, N. Agrawal7, W. Tian8, M. Cooper9

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Wisconsin, Madison, WI, 3University of Alabama, Birmingham, AL, 4Cleveland Clinic, Cleveland, OH, 5Cedars-Sinai Medical Center, Los Angeles, CA, 6CareDx Inc., Brisbane, CA, 7CareDx Inc, Brisbane, CA, 8CareDx, Brisbane, CA, 9MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…
  • 2022 American Transplant Congress

    Conversion from Immediate to Extended-Release Tacrolimus (LCP-Tac) Six Months After Renal Transplantation Optimizes Safety and Efficacy

    S. P. Patel, F. Bartlett, T. Sprague, J. Newman, E. Andrade, N. Rao, N. Patel, D. Dubay, V. Rohan, M. Casey, D. Taber

    MUSC Health, Charleston, SC

    *Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for prevention of rejection in kidney transplant recipients (KTRs) that may have less variability and…
  • 2022 American Transplant Congress

    Galectin-3 is Predictive of 30-Day Acute Rejection Following Liver Transplantation

    D. Yoeli, T. Ferrell, I. Rodriguez, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, R. Choudhury, M. Adams, T. Nydam, E. Pomfret, C. Huang, H. Moore, N. Navarro Alvarez

    University of Colorado Anschutz Medical, Aurora, CO

    *Purpose: Galectin-3 (Gal3) is a beta-galactoside binding lectin that plays a key role in inflammation and immune response. Studies on Gal3 in liver transplantation are…
  • 2022 American Transplant Congress

    Rhinovirus Infection in Solid Organ Transplant Recipients

    G. Motoa1, M. A. Mendoza1, M. Raja1, J. Simkins2, S. Anjan2, E. Martin2, A. Phancao2, N. Sinha2, L. Abbo1, G. Guerra2, Y. Natori2

    1Jackson Memorial Hospital / University of Miami, Miami, FL, 2Miami Transplant Institute – University of Miami, Miami, FL

    *Purpose: Respiratory viral infections are one of the most common infections in solid organ transplant recipients (SOTR), causing significant morbidity and mortality. Limited data is…
  • 2022 American Transplant Congress

    The Role Of Combined Gene Expression Profiling And Donor-derived Cell-free Dna In Differentiating Acute Rejection In Liver Transplant Recipients

    S. Park1, M. Kandpal2, K. Guo2, S. Kleiboeker3, R. Sinha4, M. Abecassis5, J. Levitsky6

    1Transplant nephrology, Northwestern University, Chicago, IL, 2Northwestern University, Chicago, IL, 3Eurofins Viracor, Lee's Summit, MO, 4Eurofins Viracor, Lee's summit, MO, 5University of Arizona, Tucson, AZ, 6Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: In our previous studies, blood-based gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) have been independently validated in liver transplant recipients (LTR) to…
  • 2022 American Transplant Congress

    De Novo Focal Segmental Glomerulosclerosis in the Kidney Allograft: Association with Alloimmunity Leading to Poor Outcome

    J. Leon1, J. Duong Van Huyen2, A. Abderrahmane1, D. Anglicheau1, C. Legendre1, M. Rabant2

    1KIDNEY TRANSPLANTATION, Necker Hospital, Paris, France, 2KIDNEY PATHOLOGY, Necker Hospital, Paris, France

    *Purpose: Focal Segmental Glomerulosclerosis (FSGS) can be found de novo (Dn) or as a recurrence in kidney allograft. While FSGS recurrence has been extensively described…
  • 2022 American Transplant Congress

    Immunosuppressant Medications Use in Patients with Transplant Failure: A Canadian Multi-Centre Prospective Study

    G. Knoll1, M. Chassé2, D. Fergusson3, A. A. House4, O. Johnston5, R. Mainra6, D. Baran7, D. Treleaven8, l. senecal9, L. Tibbles10, M. Hebert11, M. Karpinski12, T. Campbell13, T. Ramsay14, J. Kim15, I. Houde16, C. White17, J. Perl15, P. Karnabi18, J. Gill5

    1Nephrology, Ottawa Hospital Research Institute, Ottawa, ON, Canada, 2University of Montreal, Montreal, QC, Canada, 3Ottawa Hospital Research Institute, Ottawa, ON, Canada, 4Nephrology, Western University, London, ON, Canada, 5Nephrology, University of British Columbia, Vancouver, BC, Canada, 6Nephrology, University of Saskatchewan, Saskatoon, SK, Canada, 7Nephrology, McGill University, Montreal, QC, Canada, 8Nephrology, McMaster University, Hamilton, ON, Canada, 9Nephrology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada, 10Nephrology, University of Calgary, Calgary, AB, Canada, 11Nephrology, University of Montreal, Montreal, QC, Canada, 12Nephrology, University of Manitoba, Winnipeg, MB, Canada, 13University of Alberta, Alberta, AB, Canada, 14Ottawa Hospital Research Institute, Ottawa, ON, Canada, 15University of Toronto, Toronto, ON, Canada, 16Laval University, Que´bec, QC, Canada, 17Queen's University, Kingston, ON, Canada, 18Ottawa Health Research Institute, Ottawa, ON, Canada

    *Purpose: This prospective study determined the association of immunosuppressant medication use with the outcomes of death, hospitalized infection, rejection of the failed allograft, and panel…
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