Articles tagged "Rejection"

2022 American Transplant Congress
Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions
M. J. Ellis¹, T. Maw², E. Huang³, E. Stites⁴, F. Shihab⁵, D. C. Brennan⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, S. Kung⁸
¹Duke University, Durham, NC, ²University of Southern California, Los Angeles, CA, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of Colorado, Aurora, CO, ⁵University of Utah, Salt Lake City, UT, ⁶Johns Hopkins School of Medicine, Baltimore, MD, ⁷CareDx, Brisbane, CA, ⁸University of California, San Francisco, San Francisco, CA
*Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…
2022 American Transplant Congress
Comparative Case Study of Mycobacterium Infections in Pediatric Post Intestinal Transplant
S. Yerina¹, R. Kanthula¹, Y. Rekhtman², S. Kaufman¹, U. Ekong¹, N. Yazigi¹, T. Fishbein¹, A. Kroemer¹, C. Matsumoto¹, K. Khan¹
¹Transplant, Georgetown University Hospital, Washington, DC, ²GI and Nutrition, Prisma Health Midlands Children's Hospital, Columbia, SC
*Purpose: We describe two rare and challenging post pediatric intestinal transplant cases with both Mycobacterium (M) Abscessus and Mycobacterium (M) Immunogenum in post surgical site…
2022 American Transplant Congress
A Novel, High Throughput Droplet Digital PCR-Based Indel Quantification Method for the Detection of Circulating Donor-Derived Cell-Free DNA After Kidney Transplantation
J. G. Verhoeven¹, K. Boer¹, A. M. Peeters¹, M. C. Clahsen-van Groningen², J. I. Roodnat¹, J. van de Wetering¹, D. Nieboer³, D. A. Bost⁴, C. C. Baan¹, D. A. Hesselink¹
¹Department of Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands, ²Department of Pathology, University Medical Center Rotterdam, Rotterdam, Netherlands, ³Department of Public Health, University Medical Center Rotterdam, Rotterdam, Netherlands, ⁴JETA Molecular, Utrecht, Netherlands
*Purpose: Donor-derived cell-free DNA (ddcfDNA) is a promising minimally invasive biomarker for acute rejection (AR) in kidney transplant recipients. To assess the diagnostic value of…
2022 American Transplant Congress
Donor-Derived Cell-Free DNA and Gene Expression Profiling for Surveillance of Renal Allograft Injury and Rejection
A. N. Carrier, A. Crane, M. Pinedo, A. Bartosic, A. Haririan, J. R. Scalea, M. R. Weir, J. S. Bromberg
University of Maryland, Baltimore, MD
*Purpose: Donor derived cell free DNA (dd-cfDNA) and gene expression profiling offer non-invasive methods of early detection of graft injury and rejection in solid organ…
2022 American Transplant Congress
Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection
R. R. Urie¹, D. Farris², A. Morris¹, E. Lombard¹, J. Z. Li³, D. Goldstein², L. Shea¹
¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Human Genetics, University of Michigan, Ann Arbor, MI
*Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
2022 American Transplant Congress
Urine-based Assay For Detection Of Acute Rejection In Pediatric Kidney Transplant Recipients
C. Crane¹, K. Zeeb², E. Phebus², C. Benavides², W. Wong³, E. Ingulli²
¹UCSD/Rady Children's Hospital, San Diego, CA, ²UCSD Rady Children's Hospital, San Diego, CA, ³Massachusetts General Brigham, Boston, MA
*Purpose: Biomarkers such as donor-derived cell free DNA (cfDNA) and gene expression profiling are utilized in adult transplant patients (pts), but these tests lack sensitivity…
2022 American Transplant Congress
HLA-DR/DQ Single Molecule Eplet Mismatch and Formation of De Novo Donor-Specific Anti-HLA Antibodies After Kidney Transplantation in Children
V. K. Sigurjonsdottir¹, K. Piburn¹, P. C. Grimm¹, B. M. Zhang²
¹Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, ²Histocompatibility and Immunogenetics Laboratory, Stanford Blood Center, Palo Alto, CA
*Purpose: The advances in HLA typing methods and elucidation of three-dimensional molecular structures of HLA antigens in recent years have allowed analysis of donor/recipient HLA…
2022 American Transplant Congress
Impact of Low Dose Donor-Specific HLA Antibodies in Living and Deceased Donor Kidney Transplantation
H. Lee¹, I. Sun², C. Yang¹, B. Chung¹
¹Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's hospital, Seoul, Korea, Republic of, ²Division of Nephrology, Department of Internal Medicine., Presbyterian Medical Center, Jeonju, Korea, Republic of
*Purpose: The prognostic value of low level preformed donor-specific antibodies (DSA) remains controversial for kidney transplantation. The aim of the present study was to investigate…
2022 American Transplant Congress
Impact of Cytomegalovirus Infection on mRNA Expression Utilizing the Molecular Microscope in Heart Transplant Recipients
S. S. Patlolla, J. Van Zyl, K. Castro, S. Mckean, R. Patel, S. Carey, A. Alam, S. Hall
Cardiology, Baylor University Medical Center, Dallas, TX
*Purpose: Little is known about the effect of CMV infection on transplant messenger RNA expression utilizing the molecular microscope (MMDx) in the absence of acute…
2022 American Transplant Congress
Transitional-1 B Cell IL-10/TNFα Ratio Risk-Stratifies Renal Transplant Patients with Early Borderline Change
A. Cherukuri, P. Randhawa, S. Hariharan, D. Rothstein
Thomas E. Starzl Transplantation Institute, UPMC, Pittsburgh, PA
*Purpose: Recent studies have shown that Banff borderline change (BLC) on allograft biopsies (Bx) is associated with decreased graft survival. However, many patients with BLC…

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