2019 American Transplant Congress
The Impact of Early Subtherapeutic Tacrolimus Troughs with Alemtuzumab Induction
1Tampa General Hospital, Tampa, FL, 2Florida Kidney Physicians, Tampa, FL
*Purpose: Prior studies in kidney transplant recipients (KTR) have demonstrated that lower tacrolimus (TAC) exposure during the first week is associated with an increased incidence…2019 American Transplant Congress
Use of an Ideal Body Weight-Based Rabbit Anti-Thymocyte Globulin Dosing Protocol in Kidney Transplant Recipients to Decrease Cost and Maintain Outcomes at a Large Academic Medical Center
1Pharmacy, Mayo Clinic, Rochester, MN, 2Transplantation Surgery, Mayo Clinic, Rochester, MN
*Purpose: This quality improvement study sought to assess if rejection post-transplant was increased following implementation of an ideal body weight (IBW)-based dosing protocol for patients…2019 American Transplant Congress
Use of Eculizumab for Active Antibody-Mediated Rejection That Occurs Early Post-Kidney Transplantation: A Consecutive Series of 15 Cases
*Purpose: Active antibody-mediated rejection (ABMR) that occurs during the amnestic response within the first month post-transplant is a rare but devastating cause of early allograft…2019 American Transplant Congress
Deficiency of the Transcription Factor Satb1 in T Cells Promotes Solid Organ Allograft Survival
*Purpose: Conventional CD4+ T cells are key effectors of allograft rejection and novel therapies limiting their response may hold promise in the context of organ…2018 American Transplant Congress
Depletion Resistant Effector Memory T Cells Mediate Thymoglobulin Refractory Allograft Rejection in Human Intestinal Transplant Recipients
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. This study aimed to determine the mechanisms underlying T cell depletion-resistant moderate to severe acute cellular rejection (ACR) in intestinal transplantation (ITx) patients.B. A…2018 American Transplant Congress
Precision Medicine for Determining the Efficacy of a Novel Belatacept Regimen
Transplant Nephrology, UCSF, San Francisco, CA.
IntroBelatacept is increasingly used as maintenance immunosuppression to improve long term outcomes in kidney transplant. Since acute rejection in patients on belatacept have been noted…2018 American Transplant Congress
“Majority Rules”: A Method to Reduce Variability in Diagnosing Antibody Mediated Rejection in Renal Allograft Biopsies Using Banff 2013
1Mayo Clinic, Rochester, MN; 2Mayo Clinic, Scottsdale, AZ; 3Mayo Clinic, Jacksonville, FL.
Introduction: The Banff 2013 criteria for diagnosing antibody-mediated rejection (ABMR) includes three lesions: glomerulitis (g), peritubularitis (PTC), and chronic glomerulopathy (cg). The poor reproducibility of…2018 American Transplant Congress
Donor-Specific Antibody Mediates Chronic, but Not Acute, Kidney Allograft Rejection in the Absence of Natural Killer Cells
Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
The incidence of antibody-mediated kidney graft rejection continues to increase. We previously reported that dysregulated donor-specific antibody (DSA) responses were induced in B6.CCR5-/- mice transplanted…2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…2018 American Transplant Congress
Donor-Derived Cell-Free DNA Outperforms Serum Creatinine Changes for Identifying Kidney Transplant Rejection
Purpose: In the DART study, donor-derived cell-free DNA (dd-cfDNA) discriminated biopsy-based diagnosis of active rejection in kidney transplant patients but serum creatinine (sCr) level did…
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