Articles tagged "Rejection"

2019 American Transplant Congress
Borderline Lesions Following Lymphocyte Depletion: Effect of Treatment
N. Wilson¹, S. Tremblay¹, P. Lee¹, S. Bumb¹, R. R. Alloway¹, J. Kremer², A. R. Shields², E. S. Woodle¹
¹University of Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH
*Purpose: A consensus does not exist on whether to treat borderline lesions in the renal allograft. Importantly, recent data suggests that borderline lesions confer risk…
2019 American Transplant Congress
Inadequate (ax) Transbronchial Biopsies Are Not Associated With Clad Or Death After Lung Transplantation
L. Levy¹, E. Huszti², J. Tikkanen³, R. Ghany³, S. Keshavjee³, T. Martinu³
¹Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada, ²Biostatistics Research Unit, University Health Network, University of Toronto, Toronto, ON, Canada, ³Lung transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada
*Purpose: Acute cellular rejection (ACR) in lung transplantation is defined by perivascular and interstitial mononuclear infiltrates on lung allograft pathology. Procuring a good quality transbronchial…
2019 American Transplant Congress
Donor-Derived Cell-Free DNA (dd-cfDNA) Course after Rejection in Pediatric Kidney Transplant Recipients
R. D. Swinford¹, A. M. De Golovine¹, C. Bell¹, A. Pai¹, A. R. Edwards¹, S. Connor², J. S. Bynon¹
¹Pediatrics, UTHealth, McGovern Medical School, University of Texas at Houston, Houston, TX, ²Transplantation, Memorial Hermann Hospital, Houston, TX
*Purpose: Accurate identification of successful treatment for rejection (R) without repeat kidney biopsy (KB) in kidney transplantation is an unmet need. The few existing biomarkers…
2019 American Transplant Congress
IL-21 Induces the Transformation of Th Cell Subsets in Acute Rejection after Kidney Transplantation
H. Deng, R. Wang, J. Shen, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: IL-21 exhibits a wide range of immunomodulatory functions in the organism, regulating immune cells such as B cells and T cells. In this study,…
2018 American Transplant Congress
Belatacept in Kidney Transplant Recipients with Preformed Donor Specific Anti-HLA Antibodies: Results of the BELACOR Trial
C. Leibler,¹ F. Canoui,² M. Matignon,¹ E. Rondeau,³ A. Zarour,² A. Durrbach,⁴ S. Malard,⁵ P. Grimbert.¹
¹Nephrology Transplantation, APHP Henri Mondor, Creteil, France; ²Public Health, APHP Henri Mondor, Creteil, France; ³Nephrology Transplantation, APHP Tenon, Paris, France; ⁴Nephrology Transplantation, APHP Bicêtre, Le Kremlin Bicêtre, France; ⁵Histocompatibility, APHP Saint Louis, Paris, France.
IntroductionAntibody-mediated rejection (ABMR) is currently a critical question in kidney transplant recipient with immunological risk factors such as pre transplant donor-specific anti HLA antibodies (DSA).…
2018 American Transplant Congress
Chronic Antibody Mediated Rejection in Renal Allografts Shows RNA Transcript Patterns That Evolve with Stage
A. Rosales,¹ B. Adam,² M. Mengel,² T. Oura,¹ M. Matsunami,¹ T. Kawai,¹ A. Cosimi,¹ R. Smith,¹ R. Colvin.¹
¹Massachusetts General Hospital, Boston, MA; ²University of Alberta, Edmonton, AB, Canada.
Purpose. Four stages of chronic antibody mediated rejection (CAMR) in renal allografts have been defined in humans and non-human primates (NHP), beginning with donor specific…
2018 American Transplant Congress
Macrophage Depletion of RCMV-Latently Infected Allografts Ameliorates Accelerated Chronic Cardiac Rejection
J. Burg,¹ N. Haese,² T. Andoh,² C. Kreklywich,² I. Jones,² S. Orloff,¹ D. Streblow.²
¹Abdominal Organ Transplantation, OHSU, Portland, OR; ²VGTI, OHSU, Portland, OR.
PurposeLatent donor rat cytomegalovirus (RCMV) infection accelerates chronic rejection (CR) in a heterotopic rat heart transplant model. RCMV latency is associated with an influx of…
2018 American Transplant Congress
Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)
H. Dai,¹ P. Lan,² A. Friday,¹ A. Williams,¹ M. Oberbarnscheidt,¹ X. Li,² F. Lakkis.¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA; ²Immunobiology, Houston Methodist Hospital, Houston, TX.
Monocytes distinguish between self and allogeneic non-self and contribute to allograft rejection by generating mature, IL-12+, DCs. The initial trigger of monocyte differentiation to DCs…
2018 American Transplant Congress
Influence of X-Ray Repair Cross-Complementing Group (XRCC) Genes Polymorphisms on the Development of Antibody-Mediated Rejection (ABMR) in Renal Transplant Recipients
Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.
Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
The importance of antibody-mediated rejection (ABMR) on the renal transplant recipients has been recognized in recent years. However, the pathogenesis of ABMR following kidney transplantation…
2018 American Transplant Congress
Clinical Response to Salvage Bortezomib Therapy for Antibody Mediated Rejection and Mixed Acute Rejection in a High Immunologic Risk Renal Transplant Population
A. Lichvar, J. Benken, E. Benedetti.
University of Illinois at Chicago, Chicago, IL.
Background: Proteasome inhibitor (PI) containing regimens treat antibody mediated rejection (AMR) and mixed acute rejection (MAR) due to elimination of donor specific antibody (DSA). Commonly,…