Articles tagged "Rejection"

2019 American Transplant Congress
Adjunctive Therapy With Tocilizumab For Treatment Of Acute Antibody Mediated Rejection – 2 Year Experience
K. Venkatachalam, R. Delos Santos, B. Heady, A. Malone, T. Alhamad
Washington University, St. Louis, MO
*Purpose: Reporting our center's experience in use of tocilizumab for treatment of antibody mediated rejection*Methods: We have previously reported the efficacy of Tocilizumab (TCZ), an…
2019 American Transplant Congress
Biomarkers in Multivisceral and Intestinal Transplantation
D. A. Cheung¹, J. Garcia¹, T. Beduschi², A. H. Langshaw¹, K. L. Arheart³, I. A. Gonzalez⁴
¹Pediatric Gastroenterology, University of Miami, Miami, FL, ²Surgery, Division of Liver/GI Transplant, University of Miami, Miami, FL, ³Public Health Sciences, Division of Biostatistics, University of Miami, Miami, FL, ⁴Pediatric Infectious Diseases and Immunology, University of Miami, Miami, FL
*Purpose: Multivisceral transplant (MVT) and isolated intestinal transplant (ITx) are complex surgical procedures that result in a pro-inflammatory state, making interpretation of biomarkers in the…
2019 American Transplant Congress
IgG4 Subclass Class 2 Donor Specific Antibody (DSA) is Associated with Subclinical Rejection in Stable Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests
A. Jackson¹, S. Kanaparthi², B. Burrell³, D. Lucas⁴, R. Vega⁴, A. J. Demetris⁵, S. Feng⁶
¹Surgery, Duke University, Durham, NC, ²The Immune Tolerance Network, Bethesda, MD, ³Immune Tolerance Network, Bethesda, MD, ⁴Medicine, Johns Hopkins University, Baltimore, MD, ⁵Pathology, University of Pittsburgh, Pittsburgh, PA, ⁶Surgery, University of California San Francisco, San Francisco, CA
*Purpose: DSA is a known biomarker of allograft rejection, yet injury phenotype and potential differ across organs. Among pediatric LT recipients entering iWITH (NCT01638559), an…
2019 American Transplant Congress
Iguratimod Inhibits the Donor Specific Antibodies Production and Attenuates the Antibody Mediated Rejection in Rat Kidney Transplantation
Z. Wang, M. Zheng, H. Chen, S. Li, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was designed to investigate the efficacy and related mechanisms of Iguratimod (T-614) in the inhibition of DSAs following kidney transplantation.*Methods: A rat…
2019 American Transplant Congress
Tocilizumab for Refractory Antibody-Mediated Rejection in Pediatric Kidney Transplantation
A. Dokras, C. Butler, Q. Zhang, E. Reed, R. Ettenger, P. Weng, M. Pearl
University of California, Los Angeles, Los Angeles, CA
*Purpose: IL-6 blockade may play a role in reducing human leukocyte antigen donor specific antibodies (HLA DSA) production and stabilizing allograft function. We aimed to…
2019 American Transplant Congress
Extracellular Vesicles (EV) Mediate Antibody-Independent Tubular Senescence via Cyclin-Dependent Kinase Inhibitors p21/p16 in Antibody-Mediated Rejection (AMR)
C. Divella¹, A. Stasi¹, R. Franzin¹, F. Sallustio², C. Curci¹, G. Merlotti³, M. Quaglia³, L. Gesualdo¹, V. Cantaluppi¹, G. Castellano¹
¹Emergency and Organ Transplantation, University of Bari, Bari, Italy, ²Emergency and Organ Transplantation / Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy, ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
*Purpose: Recent data suggest a strong correlation between kidney injury and the occurrence of accelerated senescence process, known as “Inflammaging”. However, the role of TEC…
2019 American Transplant Congress
Molecular Microscope Proves i-IFTA Lack of Specificity
A. Perkowska-Ptasinska¹, M. Ciszek², D. Deborska-Materkowska¹, A. Debska-Slizien³, P. F. Halloran⁴, M. Myslak⁵
¹Warsaw Medical Univeristy, Warsaw, Poland, ²Department of Immunology, Transplantology and Internal Diseases, Warsaw Medical Univeristy, Warsaw, Poland, ³Gdansk Medical University, Gdansk, Poland, ⁴ATAGC, University of Alberta, Edmonton AB, AB, Canada, ⁵Pomeranian Medical University, Szczecin, Poland
*Purpose: According to 2017 Banff classification, inflammatory infiltrate in the fibrotic renal tissue with at least moderate total inflammations score (ti≥2), and tubulitis (t≥2) should…
2019 American Transplant Congress
Iguratimod Attenuates the Production of Donor Specific Antibody by Inducing CD19⁺Tim-1⁺ Regulatory B Cells and Imbalance of Th17 Treg
Z. Wang, S. Fei, H. Chen, Z. Han, L. Sun, J. Tao, X. Ju, M. Zheng, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: This study was designed to investigate the effect and mechanisms of Iguratimod on circulating DSA and allograft survival in a skin transplant model.*Methods: Mice…
2019 American Transplant Congress
Liquid Biopsy for Chronic Rejection after Kidney Transplantation. A Novel Non-Invasive Biomarker Involved in Inflammatory Amplifier
Y. Takada¹, D. Kamimura², H. Higuchi¹, D. Iwami¹, K. Hotta¹, N. Iwahara¹, N. Shinohara¹, M. Murakami²
¹Renal and Genitourinary Surgery, Hokkaido University Hospital, Sapporo, Japan, ²Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
*Purpose: In kidney transplantation (KTx), despite recent advances of medical technology, chronic rejection accounts for 25% of the graft loss. Chronic active antibody-mediated rejection (CAAMR)…
2019 American Transplant Congress
Effect of Human Leukocytic Antigen Matching on Clinical Outcomes after Deceased Donor Renal Allograft Transplant: A Single Centre Experience
M. E. Gramlick¹, M. K. Heer², S. Yausis², P. R. Trevillian²
¹Department of Surgery, John Hunter Hospital, Newcastle, Australia, ²Newcastle Transplant Unit, John Hunter Hospital, Newcastle, Australia
*Purpose: Human leucocyte antigen (HLA) matching has been the cornerstone of kidney allocation policies. With increasing expertise in assessing and managing immunological risks, the impact…