2019 American Transplant Congress
Combination of Ketoconazole and Tacrolimus Increases the Risk of Kidney Transplant Rejection in African Americans
Nephrology, Tulane University, New Orleans, LA
*Purpose: African American patients generally have a rapid metabolism and thus require higher doses of tacrolimus after kidney transplantation. Ketoconazole inhibits tacrolimus metabolism and can…2019 American Transplant Congress
Impact of Six-Month Surveillance Biopsies and Monitoring on 2-Year Outcomes in Pediatric Renal Transplant Recipients
*Purpose: Evaluate the utility of surveillance biopsies on post-transplant outcomes.*Methods: A retrospective single center chart review of pediatric renal transplant recipients from 01/2011-10/2015 was conducted.…2019 American Transplant Congress
Daratumumab for Treatment of Antibody-Mediated Rejection in a Kidney Transplant Recipient
*Purpose: Antibody-Mediated Rejection (ABMR) is a severe form of rejection mediated by B-cells, plasma cells and antibodies. The consequences to the patients with ABMR are…2019 American Transplant Congress
Peripheral Blood Regulatory T Cells In The Folow In The Kidney-transplant Patients
*Purpose: Investigate the peripheral blood levels of CD4+CD25+FOXP3p3+ regulatory T cells (Tregs) in patients with kidney transplant at least one year after kidney transplantation and…2019 American Transplant Congress
De Novo Complement-Activating Donor Specific Antibodies in Pediatric Renal Transplant Recipients Are Highly Responsive to Therapy
Pediatric Nephrology, Stanford, Los Altos, CA
*Purpose: Antibody mediated rejection remains a common cause for pediatric renal allograft loss. After recognizing that graft failure was more common in our pediatric renal…2019 American Transplant Congress
The Role of Neutrophil Extracellular Traps in Kidney Acute Antibody-Mediated Rejection
*Purpose: Previously our group assessed the spontaneous and lipopolysaccharide-induced NETosis with confocal microscopy in kidney transplant recipients (KTR). We found an enhanced spontaneous NETosis regardless…2019 American Transplant Congress
Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Chronic Active Antibody-Mediated Rejection
*Purpose: Chronic active antibody mediated rejection (cABMR) is a major cause of long-term kidney transplant (KT) loss. Current therapies have unclear efficacy and significant side…2019 American Transplant Congress
A Novel Genomic Approach for Acute Rejection across All Age Groups in Kidney Transplantation
Pediatrics/Surgery, Duke University, Durham, NC
*Purpose: Acute Rejection remains a significant complication in kidney transplantation that affects long-term outcomes. Using a large collection of gene expression data obtained from multiple…2019 American Transplant Congress
FcγRIIB is a Novel CD8+ Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients
*Purpose: To understand the functional role and clinical relevance of FcγRIIB on CD8+ T cells in transplantation.*Methods: See results*Results: FcγRIIB is the sole inhibitory Fcγ…2019 American Transplant Congress
Expression of Prostaglandin E2 Receptors Track with Rejection in Porcine Kidney Transplants
*Purpose: Prostaglandin E2 (PGE2) is generated from arachidonic acid via cyclooxygenase-2 (COX2) and is known to modulate the immune response via its receptors: EP1, EP2,…
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