Articles tagged "Rejection"

2019 American Transplant Congress
A Metagene Signature of Lymphocytic Bronchitis Following Lung Transplantation
J. R. Greenland¹, P. Wang², J. J. Brotman², R. Ahuja¹, T. A. Chong², M. Kleinhenz², L. E. Leard², J. A. Golden², S. R. Hays², J. P. Singer², J. Kukreja³, N. Y. Greenland⁴, Z. Lasik⁴, P. Blanc¹
¹Medicine, VA Health Care System, San Francisco, CA, ²Medicine, University of California, San Francisco, CA, ³Surgery, University of California, San Francisco, CA, ⁴Pathology, University of California, San Francisco, CA
*Purpose: Lymphocytic bronchitis (LB) precedes chronic lung allograft dysfunction (CLAD). Peri-vascular (A-grade) and peri-bronchiolar (B-grade) lymphocytic inflammation are traditional markers of acute cellular rejection. The…
2019 American Transplant Congress
Tissue Resident Memory T Cells in Murine Renal Transplantation
K. Abou-Daya, D. Zhao, R. Tieu, A. Williams, M. Oberbarnscheidt, F. Lakkis
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…
2019 American Transplant Congress
Single Cell Analysis of Kidney Allograft Rejection
C. M. Castro-Rojas¹, K. M. Roskin², C. G. Moore², B. Abu Jawdeh³, N. Salomonis², R. R. Alloway⁴, E. Woodle⁴, D. A. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH, ²Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH, ³Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH
*Purpose: Rejection therapies (corticosteroids and antilymphocyte globulins) have not changed in over 50 years. In part this is due to a knowledge deficit of signaling…
2019 American Transplant Congress
CD19⁺Tim-1⁺ Regulatory B Cells Mediate the Balance of Th17 Treg to Decrease the Level of Donor-Specific Antibodies in Mice Secondary Skin Transplantation Model
Z. Wang, S. Fei, H. Chen, L. Sun, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: In this study, we were aimed to explore the potential influence of CD19+Tim-1+ Regulatory B cells (Bregs) on the production of DSAs in a…
2019 American Transplant Congress
Transcriptional Changes in PBMC Associated with Development of Infection and Rejection in Older and Younger Kidney Transplant Recipients
J. Schaenman¹, M. Rossetti², E. Liang¹, O. E. Beaird¹, S. Bunnapradist³, E. F. Reed², S. Cole⁴
¹Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Changes in immune response are central to vulnerability to infection and rejection, especially for the growing numbers of older kidney transplant recipients. We sought…
2019 American Transplant Congress
Impact of Induction Choice and Early Steroid Withdrawal on Outcomes in HLA Zero Mismatched Kidney Transplant Recipients
C. Votruba¹, K. Holdener¹, B. Astor², F. Aziz², D. Mandelbrot²
¹Pharmacy, University of Wisconsin Hospitals and Clinics, Madison, WI, ²Nephrology, University of Wisconsin Hospitals and Clinics, Madison, WI
*Purpose: Ideal induction and immunosuppression therapy for 6-antigen HLA matched deceased and living kidney transplant recipients (KTR) is not well understood.*Methods: All 6-antigen HLA matched…
2019 American Transplant Congress
Broadly Profiling the Activation Status of Circulating Immune Cells in Chronic Active Antibody Mediated Rejetion Reveals Increased CD38 and CD16 Expression on Monocytes and NK Cells
K. Sablik, N. Litjens, M. Klepper, M. Betjes
Erasmus MC, Rotterdam, Netherlands
*Purpose: Chronic-active antibody mediated rejection (c-aABMR) contributes significantly to late renal allograft failure. Non-invasive biomarkers of c-aABMR are currently not available but could be valuable…
2019 American Transplant Congress
Successful Use of Nonantigen Specific Immunoadsorption In ABO-Incompatible Desensitization and Humoral Rejection Treatment in Kidney Transplantation
E. Montagud-Marrahi
Servei de Nefrologia i Trasplantament Renal, Hospital Clínic de Barcelona, Barcelona, Spain
*Purpose: : Immunoadsorption (IA) is an apheresis procedure that has been shown to be effective in the ABO incompatible living donor kidney transplantation (ABOi LDKT)…
2019 American Transplant Congress
Perioperative Blood Transfusion and Risk for Post-Transplant Sensitization and Rejection
A. Chung¹, M. Kleman¹, T. Pesavento¹, M. Abdel-Rasoul², R. Daloul¹
¹Internal Medicine, Division of Nephrology, The Ohio State University, Columbus, OH, ²Center for Biostatistics and Bioinformatics, The Ohio State University, Columbus, OH
*Purpose: Pre-transplant blood transfusion is a well-established risk factor for sensitization to human leukocyte antigens (HLA). HLA sensitization is associated with increased wait-list time, risk…
2019 American Transplant Congress
Borderline Lesions Following Lymphocyte Depletion: Effect of Treatment
N. Wilson¹, S. Tremblay¹, P. Lee¹, S. Bumb¹, R. R. Alloway¹, J. Kremer², A. R. Shields², E. S. Woodle¹
¹University of Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH
*Purpose: A consensus does not exist on whether to treat borderline lesions in the renal allograft. Importantly, recent data suggests that borderline lesions confer risk…