Articles tagged "Rejection"

2019 American Transplant Congress
Induction with Thymoglobulin in DCD Kidneys. Dose Effect and Predictors of Outcome
A. Asderakis, T. Sabah, A. Jones, E. Ablorsu, L. Szabó, R. Chavez
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom
*Purpose: Thymoglobulin (ATG) is used only in few UK centres as induction. We have previously shown good results with ATG for pancreas transplants. The aim…
2019 American Transplant Congress
Periphery Blood ddcfDNA Can Significantly Differentiate Acute Humoral Rejection from Banff’s Type I Acute Rejection in Kidney Transplantation
R. Wang¹, T. Jiang², J. Shen¹, J. Ge³, W. Lei¹, X. Yang³, H. Deng¹, W. Kong¹, J. Zhou¹
¹Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China, ²Organ diagnosis company, Suzhou, China, ³Organ Diagnosis Company, Suzhou, China
*Purpose: Cell free DNA(cfDNA) was widely used in field of cancer and obstetric care. Alloantigens was existed in Organ transplantation, so donor derived cfDNA(ddcfDNA) was…
2019 American Transplant Congress
A Prospective, Randomized, Multicenter Trial of Bela-Based CNI Free and Steroid Withdrawal Immunosuppression: Best Trial Two Year Characterization of Rejection and Renal Function
A. Wiseman¹, A. R. Shields², R. R. Alloway², D. Kaufman³, J. P. Leone⁴, A. J. Matas⁵, P. West-Thielke⁶, J. Lipscomb², E. King², E. S. Woodle for the BEST Study Group²
¹University of Colorado School of Medicine, Denver, CO, ²University of Cincinnati, Cincinnati, OH, ³University of Wisconsin, Madison, WI, ⁴Tampa General, Tampa, FL, ⁵University of Minnesota, Minneapolis, MN, ⁶University of Illinois, Chicago, Chicago, IL
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal Trial) was designed to compare two BELA-based early steroid withdrawal (ESW) regimens with a TAC-based ESW regimen…
2019 American Transplant Congress
Yellow Fever and Renal Transplantation: Influence of Vaccination and Infection on the Emergence of Antibody-Mediated Rejection
M. V. Sousa¹, R. L. Zollner², R. S. Stucchi³, I. F. Boin⁴, E. C. Ataide⁴, M. Mazzali¹
¹Department of Internal Medicine - Division of Nephrology, University of Campinas, Campinas, Brazil, ²Department of Internal Medicine, University of Campinas, Campinas, Brazil, ³Department of Internal Medicine - Division of Infectious Diseases, University of Campinas, Campinas, Brazil, ⁴Surgery Department, University of Campinas, Campinas, Brazil
*Purpose: Yellow fever (YF) is a viral hemorrhagic disease transmitted by mosquitos, with variable clinical disease manifestations from a mild, undifferentiated febrile illness to severe…
2019 American Transplant Congress
Rituximab Desensitization to Liver Transplantaiton Recipients with Preformed Donor Specific Antibodies to Prevent Antibody Mediated Rejecton
Y. Ogura, M. Shizuku, N. Kurata, K. Jobara, H. Kamei
Transplantation Surgery, Nagoya University Hospital, Nagoya City, Japan
*Purpose: Preformed donor-specific antibodies (DSA) are considered as a risk factor after solid organ transplantation. Strong DSA is associated with high mortality and increased risk…
2019 American Transplant Congress
Role of RIPK3 in Chronic Rejection Following Human Lung Transplantation
S. Angara, R. Ravichandran, H. Sodawalla, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Immunological mechanisms leading to chronic rejection, bronchiolitis obliterans syndrome (BOS), following human lung transplantation remains unclear though a strong correlation have been identified between…
2019 American Transplant Congress
Incidence and Risk of Allograft Rejection after Cardiac Transplantation in Left Ventricular Assist Device Patients
R. C. Patel¹, L. B. Cooper², S. D. Barnett², R. T. Cole², M. A. Psotka², A. Cochrane², S. Sinha², L. J. Bogar², S. S. Desai², P. Shah²
¹Virginia Commonwealth University School of Medicine, Inova Fairfax Hospital, Falls Church, VA, ²Department of Heart Failure and Transplant, Inova Heart and Vascular Institute, Falls Church, VA
*Purpose: Left ventricular assist devices (LVAD) are made of biomaterials that have been shown to cause allosensitization. Single center studies have suggested that patients bridged…
2019 American Transplant Congress
The Evolving Clinical Presentation of Acute Rejection in Face Transplantation
V. Haug, B. Kollar, D. Obed, H. Kiwanuka, M. Turk, L. Wo, S. Tasigiorgos, M. Kueckelhaus, L. Riella, B. Pomahac
Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Clinical signs such as erythema or edema are traditionally helpful to diagnose Acute rejection (AR) in face transplantation (FT) in the early follow-up. The…
2019 American Transplant Congress
The Changing Face of T Cell-Mediated Rejection
A. Perkowska-Ptasinska and INTERCOMEX investigators¹, P. F. Halloran²
¹Medical University of Warsaw, Warsaw, Poland, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: We studied how the problem of TCMR in indication biopsies was changing with time by exploring features of 138 biopsies with molecular TCMR in…
2019 American Transplant Congress
The Complexity of T Cell-Mediated Rejection Scenarios: Identifying BK in Biopsies with TCMR
P. F. Halloran and The INTERCOMEX Investigators¹, G. Gupta², J. Reeve³
¹University of Alberta, Edmonton AB, AB, Canada, ²Virginia Commonwealth University, Richmond, VA, ³Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: Some transplanted kidneys have concomitant T cell-mediated rejection (TCMR) and BK virus nephropathy (BK). The histologic diagnosis in BK sometimes overlooks the TCMR component,…