2019 American Transplant Congress
Increasing Net Immunosuppression after BK Viremia
University of Michigan, Ann Arbor, MI
*Purpose: BK viremia is associated with inferior kidney allograft outcomes. Typical treatment involves reduction in immunosuppression. However reduction in immunosuppression is also likely to lead…2019 American Transplant Congress
Exosomes Isolated from Human Lung Transplant Recipients Diagnosed with Bronchiolitis obliterans Syndrome are Unique in Their Ability to Induce IL-6 via Rab27A Signaling Pathway
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Rab27, a member of the Rab subfamily of GTPases, has the ability to induce exosome secretion. Exosomes are small membrane vesicles (40-150nm) that regulate…2019 American Transplant Congress
Transcriptome Profiling Of Renal Transplant Biopsies With Acute Cellular Rejection From Patients On Calcineurin Inhibitor-based Or Cni-avoidance Immunosuppression
*Purpose: Despite their suboptimal toxicity profile, calcineurin-inhibitors (CNIs) remain the cornerstone of renal transplant immunosuppression. Previous efforts to completely eliminate CNIs failed, because CNI-avoidance protocols…2019 American Transplant Congress
Donor-Derived Cell-Free DNA is Associated Specifically with Antibody Mediated Injury in Patients with Renal Allograft Dysfunction
1Fundeni Clinical Institute, Bucharest, Romania, 2University of Washington, Seattle, WA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been proposed as a noninvasive biomarker to differentiate rejection from other types of injury in renal allografts.*Methods: We analyzed…2019 American Transplant Congress
Outcomes of ABO Incompatible Transplant on Steroid Free Immunosuppression
*Purpose: ABO incompatible (ABOi) kidney transplant (KTx) was introduced to expand donor organ pool. However it is also an immunologically high-risk procedure requiring pre-transplant antibody…2019 American Transplant Congress
Subclinical Antibody Mediation Rejection in Stable Kidney Recipients with De Novo Donor Specific Antibodies and Correlation with Donor Derived Cell Free DNA Testing
Kidney and Pancreas Transplant, University of Colorado-Denver, Aurora, CO
*Purpose: Subclinical antibody mediated rejection (sAMR) is associated with inferior graft outcomes but its diagnosis relies on the presence of biomarkers as well as histology.…2019 American Transplant Congress
Low Dose Anti-Thymocyte Globulin is Enough to Prevent Acute Cellular Rejection in Kidney Transplant
*Purpose: Rabbit anti-thymocyte globulin (rATG) cumulative dose needed to effectively and safely prevent acute cellular rejection is unknown. This study compares the efficacy of total…2019 American Transplant Congress
Urinary Microtubule-Associated Protein Light Chain3 and Neutrophil Gelatinase-Associated Lipocalin, as Potential Noninvasive Biomarkers for Subclinical Rejection at 3 Months after Kidney Transplantation
*Purpose: Biopsy proven acute rejection without clinical symptoms such as subclinical rejection (SCR) is supposed to associate graft loss in the long term post kidney…2019 American Transplant Congress
Racial Disparities in Documentation of Non-Adherence and Its Relation to Rejection in Pediatric Kidney Transplant Recipients
*Purpose: Black patients have historically been disadvantaged throughout the transplant process. Many factors impact the success of kidney transplantation, but the need for strict adherence…2019 American Transplant Congress
Is Pre-transplant Plasmapheresis For Patients With Insignificant Abo Blood Type Antibody In Abo Blood Type Incompatible Kidney Transplant Necessary? – A Japanese Single Center Study.
Urology and Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan
*Purpose: ABO incompatible kidney donor (ABOiKT) is still precious to fill up the extremely organ donor shortages in our country. Though plasmaphresis (PP) as desensitization…
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