2019 American Transplant Congress
Infectious Risk of Rejection Therapy Following Heart Transplantation; Can It Be Avoided?
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: The diagnosis of rejection after heart transplantation (HTx) is usually based on the surveillance endomyocardial biopsies (EMB). These protocol biopsies are performed at scheduled…2019 American Transplant Congress
The Potential Role of IL-33/ST2 Pathway in Renal Allograft Rejection
*Purpose: Interleukin (IL)-33 is one of IL-1 family cytokine that has pleiotropic effects, such as inflammation promotion and immune response regulation. Recent studies showed that…2019 American Transplant Congress
Continuous 24-Hour vs. Daily Antithymocyte Globulin (ATG) Infusions for Treatment of Renal Allograft Rejection: Preliminary Results of a Prospective Trial
Methodist Hospital, Houston, TX
*Purpose: When used for acute rejection (AR), ATG is generally administered in the inpatient setting, given the need for intravenous (IV) access, risk of infusion-related…2019 American Transplant Congress
Impact Of Inhaled Vasodilator Therapy On Early Morbidity And Mortality After Lung Transplant
*Purpose: Within the first 72 hours of lung transplant, recipients may develop primary graft dysfunction (PGD). This complication is associated with acute and chronic rejection,…2019 American Transplant Congress
Adjunctive Therapy With Tocilizumab For Treatment Of Acute Antibody Mediated Rejection – 2 Year Experience
Washington University, St. Louis, MO
*Purpose: Reporting our center's experience in use of tocilizumab for treatment of antibody mediated rejection*Methods: We have previously reported the efficacy of Tocilizumab (TCZ), an…2019 American Transplant Congress
Biomarkers in Multivisceral and Intestinal Transplantation
*Purpose: Multivisceral transplant (MVT) and isolated intestinal transplant (ITx) are complex surgical procedures that result in a pro-inflammatory state, making interpretation of biomarkers in the…2019 American Transplant Congress
Frailty Associated with Increased Rates of Acute Cellular Rejection within 3 Months after Liver Transplantation
*Purpose: Frailty, a state of decreased physiologic reserve and increased vulnerability to health stressors, has an inflammatory biologic basis and has been associated with dysregulation…2019 American Transplant Congress
Antibody-Suppressor CD8+ T Cells Require CXCR5
*Purpose: We previously reported the novel activity of alloprimed CD8+ T cells that suppress post-transplant alloantibody production. The purpose of the current study was to…2019 American Transplant Congress
High Numbers of Differentiated CD8+CD28– T Cells Are Associated with a Substantially Lowered Risk for Late Rejection and Graft Loss after Kidney Transplantation
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Recipients of a kidney transplant have a prematurely aged T-cell system. This is reflected in lowered thymic output, reduced telomere length and more highly…2019 American Transplant Congress
Platelets Augment Granzyme K Production By Macrophages In Antibody-mediated Rejection
Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: When antibodies bind to MHC antigens on endothelial cells a cascade of responses is initiated including exocytosis of adhesion molecules followed by attachment and…
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