2019 American Transplant Congress
The Effect Of Tacrolimus Trough Variability On Kidney Transplant Outcomes
*Purpose: High variability in tacrolimus as assessed by tacrolimus coefficient of variability (TCV) in trough levels of kidney transplant recipients (KTRs) has been associated with…2019 American Transplant Congress
Torque Teno Virus is a Prognostic Biomarker for Acute Biopsy-Proven Alloreactivity in Kidney Transplants
*Purpose: Drug-induced immunosuppression in kidney transplantation is crucial to prevent allograft rejection, but increases risk for infectious, cardiovascular and malignant disease. Tailoring of immunosuppressive drug…2019 American Transplant Congress
Detection and Desensitization of Donor-Specific Antibody Reduces Risk of Early but Not Late Renal Transplant Failure in a Cohort of 1000 Cases
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
*Purpose: The Human Organ Transplant Act in Taiwan was promulgated in 1987 and, thereafter, organ transplantation from brain-dead donors legalized. To review the results of…2019 American Transplant Congress
The Molecular Pathology of Immune Checkpoint Inhibitor-Associated Renal Allograft Rejection: Overlap with Acute Interstitial Nephritis
*Purpose: The use of immune checkpoint inhibitors (ICIs) for various malignancies has been associated with numerous immunological adverse events, including acute interstitial nephritis (AIN) in…2019 American Transplant Congress
The Impact of Early Subtherapeutic Tacrolimus Troughs with Alemtuzumab Induction
1Tampa General Hospital, Tampa, FL, 2Florida Kidney Physicians, Tampa, FL
*Purpose: Prior studies in kidney transplant recipients (KTR) have demonstrated that lower tacrolimus (TAC) exposure during the first week is associated with an increased incidence…2019 American Transplant Congress
Use of an Ideal Body Weight-Based Rabbit Anti-Thymocyte Globulin Dosing Protocol in Kidney Transplant Recipients to Decrease Cost and Maintain Outcomes at a Large Academic Medical Center
1Pharmacy, Mayo Clinic, Rochester, MN, 2Transplantation Surgery, Mayo Clinic, Rochester, MN
*Purpose: This quality improvement study sought to assess if rejection post-transplant was increased following implementation of an ideal body weight (IBW)-based dosing protocol for patients…2019 American Transplant Congress
Use of Eculizumab for Active Antibody-Mediated Rejection That Occurs Early Post-Kidney Transplantation: A Consecutive Series of 15 Cases
*Purpose: Active antibody-mediated rejection (ABMR) that occurs during the amnestic response within the first month post-transplant is a rare but devastating cause of early allograft…2019 American Transplant Congress
Deficiency of the Transcription Factor Satb1 in T Cells Promotes Solid Organ Allograft Survival
*Purpose: Conventional CD4+ T cells are key effectors of allograft rejection and novel therapies limiting their response may hold promise in the context of organ…2019 American Transplant Congress
NK Cells Are Associated with Alloimmune Failure in Transplanted Children
*Purpose: Alloimmune failure, defined as the development of donor specific antibody (DSA) and/ or allograft rejection, remains a significant complication in pediatric kidney transplantation. NK…2019 American Transplant Congress
Newly-Revealed Antibody Targets Lead to the Early Loss of Triple Knockout Pig Kidneys in a Pig to Baboon Model
*Purpose: We have achieved >6 months survival of a life-supporting kidney with a vascularized thymus (VT) in a pig-to-baboon model. While improved survival has been…
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