Articles tagged "Rejection"

2020 American Transplant Congress
Allograft Loss and Patient Death among Kidney Transplant Recipients; Is Therapy Non-Adherence the Underlying Perpetrator?
K. Kalra, R. Munjal, A. Cherukuri, R. Mehta, C. Puttarajappa, D. Jorgensen, P. Sood, C. Wu, N. Shah, S. Hariharan
Nephrology, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: To ascertain causes of allograft dysfunction, loss and death in a cohort of kidney transplant patients*Methods: In this Retrospective cohort study, 943 patients who…
2020 American Transplant Congress
Membrane Expression of CD163 and CD206 by Blood Monocytes is Upregulated in Kidney Allograft Recipients
I. Striz, L. Curnova, V. Svachova, M. Fialova, M. Novotny, O. Viklicky
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Blood monocytes differentiating into tissue macrophages or dendritic cells are involved in multiple immune responses including reactions to the transplanted allograft. Peripheral monocytes can…
2020 American Transplant Congress
Allograft Repopulating Recipient B Cells after Human Intestinal Transplantation and Their Association with Donor Specific Antibody Secretion and Rejection
E. Waffarn¹, J. Fu¹, K. Frangaj¹, W. Meng², A. M. Rosenfeld², M. Li³, K. Rodgers¹, R. Vasilescu³, E. T. Luning Prak², A. Griesemer¹, T. Kato⁴, M. Martinez⁵, M. Sykes¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, ³Department of Pathology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY, ⁵Department of Pediatrics, Columbia University, New York, NY
*Purpose: Alloantibodies produced by recipient B cells are associated with rejection after intestinal transplantation (ITx) and negatively impact patient and graft survival. However, the dynamics…
2020 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
R. El Fekih¹, A. Alghamdi¹, J. Hurley², C. Coticchia², J. Choi¹, H. Allos¹, S. Eskandari¹, S. Bentink², V. Tadigotla², L. Riella¹, J. Markmann³, K. Safa³, R. Formica⁴, J. Skog², J. Azzi¹
¹Medecine, Brigham and Women's Hospital, Boston, MA, ²Exosome Diagnostics Inc., Waltham, MA, ³Massachusetts General Hospital, Boston, MA, ⁴Yale School of Medecine, New Haven, CT
*Purpose: Monitoring kidney transplant rejection by repeated biopsies might result in increased procedural complications and cost. Exosomes are nanometer-sized vesicles released by cells carrying trans…
2020 American Transplant Congress
Three-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection – Early Impact of Interleukin-6 Blockade on Donor-Specific Antibody Levels, Rejection Morphology and Gene Expression
G. A. Böhmig¹, M. Dürr², B. Jilma³, F. Eskandary¹, E. Chong⁴, S. Schranz³, K. Doberer¹, M. Wahrmann¹, A. Borski¹, H. Regele⁵, J. Kläger⁵, R. Reindl-Schwaighofer¹, J. Reeve⁶, K. Budde², P. F. Halloran⁶
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Nephrology Department, Charité Berlin, Berlin, Germany, ³Dept. of Clin. Pharmacology, Medical University of Vienna, Vienna, Austria, ⁴Vitaeris Inc., Vancouver, BC, Canada, ⁵Dept. of Clin. Pathology, Medical University of Vienna, Vienna, Austria, ⁶Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Targeting Interleukin-6 (IL-6) is a promising strategy to counteract antibody-mediated rejection (ABMR). This phase 2 trial (NCT03444103) was designed to evaluate the safety and…
2020 American Transplant Congress
Decoding the Troubled Allograft: Proteinuria within the 1^st Post-Transplant Year Associates with and Risk Stratifies Inflamed Renal Transplants
A. Cherukuri, R. Mehta, A. Tevar, R. Munjal, K. Kalra, C. Puttarajappa, P. Sood, C. Wu, S. Hariharan
Starzl Transplantation Institute, UPMC, Pittsburgh, PA
*Purpose: The relationship between progression of proteinuria and allograft histology through the 1st year with clinical outcomes is unclear.*Methods: Here, we systematically studied proteinuria {early…
2020 American Transplant Congress
Recipient Expression of C-Type Lectin Receptor Mincle Promotes Rapid T Cell Homeostatic Recovery Following Antibody Mediated Lymphoablation
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Antibody-mediated lymphocyte depletion is widely used in transplantation. We recently established that T cell recovery in mouse heart allograft recipients treated with anti-thymocyte globulin…
2020 American Transplant Congress
Large Academic Center Experience with Treatment of Suspected/Confirmed Kidney Transplant Active Antibody Mediated Rejection
J. T. Reece¹, B. A. Steiner², V. Bhoj¹, N. Aqui¹, R. D. Bloom³, J. Trofe-Clark⁴
¹Transfusion Medicine Div, Univ of Pennsylvania, Philadelphia, PA, ²Pharmacy, Hosp of Univ of Pennsylvania, Philadelphia, PA, ³Renal Div, Univ of Pennsylvania, Philadelphia, PA, ⁴Pharmacy, Hospital of University of Pennsylvania, Philadelphia, PA
*Purpose: Therapeutic plasma exchange (TPE) and intravenous immunoglobulin (IVIG) are common active antibody mediated rejection (ABMR) treatments in kidney transplant recipients (KTRs), but with unclear…
2020 American Transplant Congress
Development of Self-Limited Low-Level BK Viremia/Viruria Suggests Ideal Immunosuppression to Suppress T-Cell and Antibody-Mediated Rejection and to Preserve Kidney Allograft Function
B. Näf, T. Müller, R. Wüthrich, T. Schachtner
University Hospital Zurich, Zurich, Switzerland
*Purpose: Polyomavirus BK (BKV) has been suggested as a surrogate marker of overimmunosuppression. Due to recent advances in monitoring strategies and pre-emptive therapy, progression to…
2020 American Transplant Congress
Polyfunctional Cytokine Secreting Th17 Cells Preferentially Infiltrate Murine Renal Allografts with Acute Rejection and Are Associated with Elevated Th17: Treg Ratio
R. Dhital¹, V. Velazquez¹, Q. Zeng², M. Shimamura¹
¹Center for Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, ²Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH
*Purpose: Our group has shown that renal transplant patients with acute rejection have elevated blood mRNA RORγt: FOXP3 ratio compared to patients with stable graft…