Articles tagged "Rejection"

2020 American Transplant Congress
Absolute Lymphocyte Count: Is There a “Safety Corridor?”
G. Elhelou¹, B. Lahr², R. Razonable³
¹Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, FL, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Medicine, Division of Infectious Disease, Mayo Clinic, Rochester, MN
*Purpose: Iatrogenic suppression of T cells is intended to prevent rejection after solid organ transplantation (SOT). This is complicated by opportunistic infections, most notably cytomegalovirus…
2020 American Transplant Congress
Determination of Programmed Cell Death Protein 1 (PD1) by Flow Cytometry, a Possible Follow-Up Tool in Renal Transplantation of High Immune Risk
M. Carmona-Escamilla¹, M. Fonseca², J. Prieto Chávez³, L. Arriaga⁴, F. Oviendo⁵, S. , Hernández-Mendoza SA², J. Alberu⁶, G. Queipo²
¹Nephrology, Hospital Central Sur Alta Especialidad "Picacho", CDMX, Mexico, ²Genetics, Hospital General de México Dr. Eduardo Liceaga-Facultad, Ciudad de México, México, CDMX, Mexico, ³Transplant, Hospital General de México Dr. Eduardo Liceaga-Facultad, Ciudad de México, México, CDMX, Mexico, ⁴Unidad de investigación en inmunoqímica,, Hospital de Especialidades Centro Médico Siglo XXI IMSS, CDMX, Mexico, ⁵Unidad de investigación en inmunoqímica,, Hospital de Especialidades Centro Médico Siglo XXI IMSS, Ciudad de México, México, CDMX, Mexico, ⁶Transplant, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX, Mexico
*Purpose: Introduction: Currently, the follow-up of patients remains to be the serum creatinine level, being highly specific, however, with little sensitivity to determine the occurrence…
2020 American Transplant Congress
Deleterious Effect of Intravenous Steroids on Bone Mineral Density in Patients Treated for Borderline Rejection of the Renal Allograft
S. T. Suliman, D. O. Hodge, M. B. Prendergast
Transplant Nephrology, Mayo Clinic, Jacksonville, FL
*Purpose: Subclinical rejection of the renal allograft is known to increase the risk of developing interstitial fibrosis and tubular atrophy which ultimately translates into shortening…
2020 American Transplant Congress
Utility of dd-cfDNA in TCMR 1A and Borderline Allograft Rejection
E. Stites¹, D. Kumar², O. Olaitan³, G. Gupta²
¹University of Colorado, Aurora, CA, ²Virginia Commonwealth University, Richmond, VA, ³Rush University, Chicago, CA
*Purpose: The value of donor-derived cell-free DNA (dd-cfDNA, AlloSure) as a molecular marker for the early diagnosis of mild T-cell mediated rejection (Banff TCMR 1A…
2020 American Transplant Congress
Development of DSA Class II is Associated with Immunosuppressive Monotherapy and Increased Risk for Graft Fibrosis, Chronic Rejection and Graft Loss
M. Sterneck¹, B. Sultani¹, A. Ozga², S. Weidemann³, J. Hermann⁴, E. Grabhorn⁵, U. Herden⁶, L. Fischer⁶
¹University Medical Center Hamburg Eppendorf, Hamburg, Germany, ²Insitute of Medical Biometry, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ³Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁴Pediatric Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁵Pediatric Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁶Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
*Purpose: Recent studies have suggested a negative impact of class 2 DSA on short term outcome of OLT recipients. The aim of this study was…
2020 American Transplant Congress
High-Activity Classical and Alternative Complement Pathway Genotypes – Association with Donor-Specific Antibody-Triggered Injury and Renal Allograft Survival
R. Reindl-Schwaighofer¹, B. Mezö², F. Eskandary¹, A. Heinzel¹, M. Wahrmann¹, K. Doberer¹, A. Heilos³, G. Bond¹, J. Kläger⁴, N. Kozakowski⁴, H. Haslacher⁵, R. Oberbauer¹, O. Viklický⁶, P. Hruba⁶, P. F. Halloran⁷, K. Rusai³, Z. Prohászka⁸, G. A. Böhmig¹
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary, ³Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, ⁶Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁷Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada, ⁸Department of Medicine III, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
*Purpose: Complement may contribute to donor-specific antibody (DSA)-triggered transplant injury. Here, we investigated whether the intrinsic strength of classical (CP) and alternative complement pathways (AP)…
2020 American Transplant Congress
Belatacept Provides Superior Inhibition of Donor Specific Antibody Formation in Kidney Transplant Recipients with Acute Rejection
O. Cristea, C. Larsen, I. Badell
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA
*Purpose: The factors responsible for chronic renal allograft dysfunction and premature graft loss are incompletely understood and likely multifactorial. Immunologic injury partially attributable to the…
2020 American Transplant Congress
Activated Circulating Memory TFollicular Helper Cells with Self-Renewal Potential Underlie the Kidney Allograft Antibody-Mediated Rejection Response
K. Louis¹, C. Macedo¹, E. Bailly¹, B. Ramaswami¹, M. Marrari¹, T. Shi¹, D. Landsittel¹, U. Chandran¹, P. Fadakar¹, M. Yamada¹, G. Chalasani¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm UMR 976, Paris, France
*Purpose: Antibody-mediated rejection (ABMR) is the leading cause of allograft failure after organ transplantation. Yet, the cellular events that lead to the induction of a…
2020 American Transplant Congress
Measuring Environmental Elemental Exposure in the Hair Allows to Identify Kidney Transplant Recipients at Risk of Acute Rejection
A. Angeletti¹, I. Gandolfini², C. Cantarelli², U. Maggiore², L. Gaetano¹, E. Fiaccadori², J. Reid-Adam³, J. Saland³, P. Curtin³, A. Curtin³, C. Austin³, P. Cravedi³
¹St. Orsola Hospital, University of Bologna, Bologna, Italy, ²Parma University, Parma, Italy, ³Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Most biomarkers are representative of a single moment in time, which, even when repeatedly assessed, may not capture trends or variability. Hair is a…
2020 American Transplant Congress
A New Diagnostic Approach to HLA Testing in Kidney Transplant Patients Using Renal Epithelial Cells
M. Herrmann¹, C. Bach², K. X. Knaup¹, M. Schiffer¹, B. Spriewald², M. S. Wiesener¹
¹Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany, ²Haematology and Oncology, University Hospital Erlangen, Erlangen, Germany
*Purpose: In this study we present a new diagnostic approach to HLA typing in kidney transplant recipients using cultured renal tubular cells from urine samples…