Articles tagged "Rejection"

2020 American Transplant Congress
Antibody-Mediated Rejection with and without Donor-Specific Anti-HLA Antibodies: Performance of the Peripheral Blood 8-Gene Expression Assay
E. Van Loon¹, E. Lerut², D. Anglicheau³, W. Gwinner⁴, M. Essig⁵, P. Marquet⁵, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²KU Leuven, Leuven, Belgium, ³Department of Nephrology and Kidney Transplantation, Necker Hospital, Paris, France, ⁴Hannover Medical School, Hannover, Germany, ⁵CHU Limoges, Limoges, France
*Purpose: Therapeutic implications of the recently discovered 8-gene expression assay are most clear for detection of antibody-mediated rejection in presence of donor-specific anti-HLA antibodies (HLA-DSA).…
2020 American Transplant Congress
The Effect of B Cell Depletion Therapies on Preformed Xenoantibodies in Transplant Recipient
S. Yeh¹, N. A. Wilson², A. Djamali², R. Redfield³
¹Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, ²Medicine/Nephrology, University of Wisconsin-Madison, Madison, WI, ³Surgery, University of Wisconsin-Madison, Madison, WI
*Purpose: To assess the effect of B cell depletion therapies on preformed xenoantibodies in transplant recipient. Preformed xenoantibodies are a significant barrier to successful xenotransplantation.…
2020 American Transplant Congress
Unsupervised Analysis of the Alloimmune Response Using Single-Cell Mass Cytometry
J. Harden, X. Wang, C. Esquivel, O. Martinez, S. Krams
Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA
*Purpose: Alloimmune responses in acute rejection are complex, involving multiple interacting cell types. Flow cytometry with biased pairwise gating is the gold standard to phenotype…
2020 American Transplant Congress
Post-Transplant Collagen I and Collagen III Antibodies and Antibody-Mediated Rejection in Kidney Transplantation Recipients
S. Park¹, S. Yang², J. Kim², Y. Kim², Y. Kim², J. Ha², K. Moon², E. Song², H. Lee²
¹Armed Forces Capital Hospital, Gyeonggi-do, Korea, Republic of, ²Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: An emerging role of non-human leukocyte antigen (HLA) antibodies on the risk of antibody-mediated rejection (AMR) has been suggested, although most of their non-HLA…
2020 American Transplant Congress
The Accuracy of the ICD-10 Diagnostic Codes for Kidney Transplant Rejection and Failure
D. Massicotte-Azarniouch¹, M. Sood², D. Fergusson³, M. Chassé⁴, A. Tinmouth⁵, G. Knoll²
¹Medicine, University of Ottawa, Ottawa Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ³Clinical Epidemiology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴Medicine, University of Montreal, Ottawa, ON, Canada, ⁵Hematology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada
*Purpose: Clinical research requires that diagnostic codes captured from routinely collected health administrative data accurately identify individuals with a disease. In this study, we examined…
2020 American Transplant Congress
Natural Course of Borderline Changes in Kidney Allografts: A MMDx Study
P. Hruba¹, K. S. Madill-Thomsen², M. Mackova², J. Maluskova³, E. Honsova³, J. Slatinska⁴, P. F. Halloran², O. Viklicky⁴
¹Transplant Laboratory, IKEM, Prague, Czech Republic, ²ATAGC, University of Alberta, Edmonton, AB, Canada, ³Department of Pathology, IKEM, Prague, Czech Republic, ⁴Department of Nephrology, IKEM, Prague, Czech Republic
*Purpose: Molecular assessment of kidney allograft biopsies with Banff borderline changes (BL) category has showed only 30% of rejection phenotype in various post-transplant follow-up and…
2020 American Transplant Congress
Relationship between Tacrolimus Levels and Short-Term Outcome in Korean Pediatric Patients with Liver Transplantation
H. Lim¹, H. Koh¹, S. Kim¹, S. Park¹, Y. Kang², M. Kim³, K. In¹
¹Severance Pediatric Liver Diseases Research Group, Severance Children’s Hospital, Severance Hospital, Seoul, Korea, Republic of, ²Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, , Wonju Severance Christian Hospital, Seoul, Korea, Republic of, ³Division of Transplantation Surgery, Department of General Surgery, Severance Hospital, Seoul, Korea, Republic of
*Purpose: Liver transplantation (LT) is a life-saving procedure in patients with end stage liver disease. After LT, immunosuppresive regimens are needed in order to prevent…
2020 American Transplant Congress
Avoiding Surveillance Biopsy: How? When? Now!
A. Ang¹, C. Schieve², S. Rose², C. Kew¹, M. R. First², R. B. Mannon¹
¹School of Medicine, University of Alabama, Birmingham, Birmingham, AL, ²Transplant Genomics Inc., Mansfield, MA
*Purpose: The TruGraf™ blood test measures a specific gene expression signature in the peripheral blood mononuclear cells to enable noninvasive serial assessment of kidney transplant…
2020 American Transplant Congress
Chronic Active T-Cell Mediated Rejection is Variably Responsive to Immunosuppressive Therapy
V. Kung¹, M. Haas¹, M. Gillespie², E. Huang², R. Sandhu²
¹Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Chronic active T cell-mediated rejection (CACMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. A key histologic feature…
2020 American Transplant Congress
The Use of Allosure Donor Derived Cell-Free DNA in a Community Based Kidney Transplant Program
V. Scantlebury, S. Gilibert, C. Sentman, H. Chang-DeGuzman, S. Swanson
Kidney Transplantation, Christiana Care Hospital, Newark, DE
*Purpose: Donor derived cell-free DNA (dd-cfDNA) has emerged as a marker of kidney allograft injury. Beginning in 2019, the dd-cfDNA monitoring has been introduced as…