Articles tagged "Rejection"

2020 American Transplant Congress
Incidence and Effects of Posttransplant Herpes Zoster in Adult Solid Organ Transplant Recipients : A Meta-Analysis
S. H. Han, D. Kwon
Yonsei University Health System, Seoul, Korea, Republic of
*Purpose: Recently, non-live recombinant subunit HZ vaccine showed highly effective for herpes zoster (HZ) in hematopoietic stem cell transplantation. Several observational studies reported various features…
2020 American Transplant Congress
The Role of Complement-Split Products as Biomarkers for Acute Antibody-Mediated Rejection of Kidney Allografts
B. G. Abu Jawdeh¹, B. Campos-Naciff¹, K. Harrison¹, K. Meganathan¹, A. Kumar², M. Anand¹, A. Govil¹, E. S. Woodle¹, B. P. Dixon³
¹University of Cincinnati, Cincinnati, OH, ²All India Institute of Medical Sciences, New Delhi, India, ³University of Colorado, Aurora, CO
*Purpose: Acute antibody-mediated rejection (AMR) is mediated by the activation of the classical complement system in addition to non-complement dependent inflammatory pathways. Complement fixation by…
2020 American Transplant Congress
Impact of a De Novo Belatacept Based Immunosuppressive Regimen on Kidney Transplant Outcomes
K. Joyal, T. Vanhove, B. Schreiber, M. Cote, S. Shao, N. Elias, H. Gilligan, K. Safa, E. Heher, W. Williams, C. Rogers
Massachusetts General Hospital Transplant Center, Boston, MA
*Purpose: Use of anti-thymocyte globulin (rabbit) (rATG) induction with belatacept/mycophenolate (MPA)/prednisone based immunosuppression (IS) has led to a reduction in rejection compared to that seen…
2020 American Transplant Congress
Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies
I. Moinuddin¹, D. Kumar¹, L. Kamal¹, A. King¹, L. Kang¹, M. Levy¹, S. Bobba¹, D. Massey¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
2020 American Transplant Congress
Allograft Loss and Patient Death among Kidney Transplant Recipients; Is Therapy Non-Adherence the Underlying Perpetrator?
K. Kalra, R. Munjal, A. Cherukuri, R. Mehta, C. Puttarajappa, D. Jorgensen, P. Sood, C. Wu, N. Shah, S. Hariharan
Nephrology, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: To ascertain causes of allograft dysfunction, loss and death in a cohort of kidney transplant patients*Methods: In this Retrospective cohort study, 943 patients who…
2020 American Transplant Congress
Membrane Expression of CD163 and CD206 by Blood Monocytes is Upregulated in Kidney Allograft Recipients
I. Striz, L. Curnova, V. Svachova, M. Fialova, M. Novotny, O. Viklicky
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Blood monocytes differentiating into tissue macrophages or dendritic cells are involved in multiple immune responses including reactions to the transplanted allograft. Peripheral monocytes can…
2020 American Transplant Congress
Allograft Repopulating Recipient B Cells after Human Intestinal Transplantation and Their Association with Donor Specific Antibody Secretion and Rejection
E. Waffarn¹, J. Fu¹, K. Frangaj¹, W. Meng², A. M. Rosenfeld², M. Li³, K. Rodgers¹, R. Vasilescu³, E. T. Luning Prak², A. Griesemer¹, T. Kato⁴, M. Martinez⁵, M. Sykes¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, ³Department of Pathology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY, ⁵Department of Pediatrics, Columbia University, New York, NY
*Purpose: Alloantibodies produced by recipient B cells are associated with rejection after intestinal transplantation (ITx) and negatively impact patient and graft survival. However, the dynamics…
2020 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
R. El Fekih¹, A. Alghamdi¹, J. Hurley², C. Coticchia², J. Choi¹, H. Allos¹, S. Eskandari¹, S. Bentink², V. Tadigotla², L. Riella¹, J. Markmann³, K. Safa³, R. Formica⁴, J. Skog², J. Azzi¹
¹Medecine, Brigham and Women's Hospital, Boston, MA, ²Exosome Diagnostics Inc., Waltham, MA, ³Massachusetts General Hospital, Boston, MA, ⁴Yale School of Medecine, New Haven, CT
*Purpose: Monitoring kidney transplant rejection by repeated biopsies might result in increased procedural complications and cost. Exosomes are nanometer-sized vesicles released by cells carrying trans…
2020 American Transplant Congress
Three-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection – Early Impact of Interleukin-6 Blockade on Donor-Specific Antibody Levels, Rejection Morphology and Gene Expression
G. A. Böhmig¹, M. Dürr², B. Jilma³, F. Eskandary¹, E. Chong⁴, S. Schranz³, K. Doberer¹, M. Wahrmann¹, A. Borski¹, H. Regele⁵, J. Kläger⁵, R. Reindl-Schwaighofer¹, J. Reeve⁶, K. Budde², P. F. Halloran⁶
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Nephrology Department, Charité Berlin, Berlin, Germany, ³Dept. of Clin. Pharmacology, Medical University of Vienna, Vienna, Austria, ⁴Vitaeris Inc., Vancouver, BC, Canada, ⁵Dept. of Clin. Pathology, Medical University of Vienna, Vienna, Austria, ⁶Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Targeting Interleukin-6 (IL-6) is a promising strategy to counteract antibody-mediated rejection (ABMR). This phase 2 trial (NCT03444103) was designed to evaluate the safety and…
2020 American Transplant Congress
Decoding the Troubled Allograft: Proteinuria within the 1^st Post-Transplant Year Associates with and Risk Stratifies Inflamed Renal Transplants
A. Cherukuri, R. Mehta, A. Tevar, R. Munjal, K. Kalra, C. Puttarajappa, P. Sood, C. Wu, S. Hariharan
Starzl Transplantation Institute, UPMC, Pittsburgh, PA
*Purpose: The relationship between progression of proteinuria and allograft histology through the 1st year with clinical outcomes is unclear.*Methods: Here, we systematically studied proteinuria {early…