Articles tagged "Rejection"

2020 American Transplant Congress
Daily Immunosuppression to Combat Compliance in Adolescent Kidney Transplant
A. L. Brubaker¹, A. McGrath², L. Maestretti², A. Chaudhuri², P. C. Grimm², A. Gallo¹
¹Surgery, Stanford University, Stanford, CA, ²Pediatrics, Stanford University, Stanford, CA
*Purpose: Medication compliance remains a persistent, multifactorial problem in adolescent renal transplant recipients. Improving adherence in this patient demographic would benefit long-term patient and graft…
2020 American Transplant Congress
Validity and Utility of Urinary CXCL10/Cr Monitoring in Pediatric Kidney Transplant Recipients
T. Blydt-Hansen¹, A. Sharma², I. Gibson², C. Weibe², A. Sharma³, V. Langlois⁴, C. Teoh⁴, D. Rush², P. Nickerson², D. Wishart⁵, J. Ho²
¹University of British Columbia, Vancouver, BC, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³University of Western Ontaria, London, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Alberta, Edmonton, AB, Canada
*Purpose: Effective post-transplant monitoring is hampered by a lack of effective biomarkers. We sought to validate the utility of urinary CXCL10/Cr monitoring of rejection in…
2020 American Transplant Congress
Humoral Sensitization Overrides Pregnancy-Induced T Cell Transplantation Tolerance
D. Tran¹, A. Suah¹, S. Khiew¹, J. Young¹, M. Andrade¹, J. Pollard¹, Q. Wang¹, D. Yin¹, G. Chalasani², M. Alegre¹, A. Chong¹
¹Department of General Surgery, University of Chicago, Chicago, IL, ²Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: There are ample clinical data that a major long-term consequence of pregnancy is humoral allosensitization. Paradoxically, pregnancy is also a state of spontaneous allogeneic…
2020 American Transplant Congress
CD38 Antibody Daratumumab for the Treatment of Chronic Antibody-Mediated Kidney Allograft Rejection
K. Doberer¹, J. Kläger², G. A. Gualdoni¹, K. Mayer¹, F. Eskandary¹, H. Agis³, T. Reiter¹, R. Reindl-Schwaighofer¹, M. Wahrmann¹, G. Cohen¹, H. Haslacher⁴, G. Bond¹, I. Simonitsch-Klupp⁵, I. Farkash⁶, P. Halloran⁷, G. A. Böhmig¹
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Dept. of Clin. Pathology, Medical University of Vienna, Vienna, Austria, ³Department of Medicine I, Medical University of Vienna, Vienna, Austria, ⁴Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, ⁵Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁶Dept. of Pathology, University of Michigan, Ann Arbor, MI, ⁷Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Late antibody-mediated rejection (ABMR) is a major cause of transplant failure. Potential therapeutic targets are plasma cells (PC) and natural killer (NK) cells expressing…
2020 American Transplant Congress
Five Year Patient Important Outcomes of Treated Acute Rejections Diagnosed with Protocol and Clinical Biopsy after Pancreas Transplant Alone for Type 1 Diabetes
Y. C. Kudva, S. R. Rizvi, R. Kaur, B. H. Smith, S. Batthula, P. G. Dean, A. Kukla, W. K. Kremers, M. D. Stegall
Mayo Clinic, Rochester, MN
*Purpose: STUDY PURPOSE: Acute rejection (AR) after Pancreas Transplant alone (PTA) continues to be a significant morbidity. We compared the outcomes of PTA recipients treated…
2020 American Transplant Congress
Anti-T Lymphocyte Immunoglobulins versus Basiliximab in Highly Sensitized Kidney-Transplant Patients without Preformed DSAs: The Satir Study
N. Kamar¹, L. Couzi², L. Albano³, A. Durrbach⁴, V. Pernin⁵, L. Esposito¹, M. Lequintrec⁵, P. Merville², A. Del Bello¹
¹Toulouse University Hospital, Toulouse, France, ²Bordeaux University Hospital, Bordeaux, France, ³Nice University Hospital, Nice, France, ⁴Henri Mondor University Hospital, Paris, France, ⁵Montpellier University Hospital, Montpellier, France
*Purpose: Two prospective studies that were performed before the era of highly sensitive solid-phase assays have shown a lower incidence of acute rejection in highly…
2020 American Transplant Congress
Single Center Experience Using Low-Dose Antithymocycte Globulin for Induction Following Heart Transplant
T. J. ONeill IV, G. Jao, A. Kelkar, B. Pisani
Wake Forest Baptist Health System, Winston Salem, NC
*Purpose: The use of induction therapy after cardiac transplantation remains highly variable, not only in terms of which agent is used, but whether it is…
2020 American Transplant Congress
Inflammatory Cytokines Have a Different Effect from One HLA-II Subclass to Another on Human Endothelium
S. Beland, F. Bouchard-Boivin, A. Gama, O. Desy, S. A. De Serres
Universite Laval, Quebec, QC, Canada
*Purpose: Development of de novo donor-specific antibodies (DSAs) is associated with antibody-mediated rejection and allograft failure. More particularly, HLA-II DSAs, especially those against DQ are…
2020 American Transplant Congress
Association between Response to Rituximab and Risk of Antibody-Mediated Rejection in ABO-Incompatible Living Kidney Transplantation
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Regulation, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Owing to limited organ availability, ABO-incompatible living kidney transplantation (ABO-ILKT) has been used extensively. Various forms of preconditioning therapies have been used alone or…
2020 American Transplant Congress
B Cell Derived IL-1β and IL-6 Drive Homeostatic T Cell Recovery Following Lymphoablation
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: T cell reconstitution after lymphoablation in allograft recipients may lead to acute rejection and poor graft outcome. Using a mouse model of heart transplantation…