Articles tagged "Rejection"

2020 American Transplant Congress
Crispr-Based Diagnostics for Rejection and Opportunistic Infection Detection in Kidney Transplantation
I. T. Lape¹, M. M. Kaminski², E. Akalin³, J. Collins², L. W. Riella¹
¹Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA, ²Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, ³Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
*Purpose: There is an unmet need in transplantation to identify allograft injury non-invasively. More than 50% of patients with kidney transplants lose their grafts within…
2020 American Transplant Congress
Early Inflammatory Lesions on Surveillance Biopsies Post Kidney Transplant is Associated with Increased Incidence of Late Clinical Rejections
I. Melgarejo¹, D. Jorgensen², K. Kalra¹, S. Tandukar², C. Puttarajappa², N. Shah², A. Sharma², P. Sood², C. Wu², S. Hariharan², R. Mehta²
¹Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, ²Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: It is unclear whether subclinical inflammation (or subclinical rejection) noted on early post transplant biopsies are associated with late clinical rejections (beyond 6 months).*Methods:…
2020 American Transplant Congress
Use of tCRM to Aid Diagnosis of Allograft Rejection in Kidney Transplantation
A. Zarinsefat¹, J. Liberto¹, I. Damm¹, C. Ramirez², J. Guerra², J. Alberu², M. Sarwal¹
¹University of California San Francisco, San Francisco, CA, ²Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico
*Purpose: To apply an unbiased, quantitative, molecular profiling score for graft inflammation using standardized assays, in the context of a prospective clinical trial in kidney…
2020 American Transplant Congress
Daily Immunosuppression to Combat Compliance in Adolescent Kidney Transplant
A. L. Brubaker¹, A. McGrath², L. Maestretti², A. Chaudhuri², P. C. Grimm², A. Gallo¹
¹Surgery, Stanford University, Stanford, CA, ²Pediatrics, Stanford University, Stanford, CA
*Purpose: Medication compliance remains a persistent, multifactorial problem in adolescent renal transplant recipients. Improving adherence in this patient demographic would benefit long-term patient and graft…
2020 American Transplant Congress
Validity and Utility of Urinary CXCL10/Cr Monitoring in Pediatric Kidney Transplant Recipients
T. Blydt-Hansen¹, A. Sharma², I. Gibson², C. Weibe², A. Sharma³, V. Langlois⁴, C. Teoh⁴, D. Rush², P. Nickerson², D. Wishart⁵, J. Ho²
¹University of British Columbia, Vancouver, BC, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³University of Western Ontaria, London, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Alberta, Edmonton, AB, Canada
*Purpose: Effective post-transplant monitoring is hampered by a lack of effective biomarkers. We sought to validate the utility of urinary CXCL10/Cr monitoring of rejection in…
2020 American Transplant Congress
Humoral Sensitization Overrides Pregnancy-Induced T Cell Transplantation Tolerance
D. Tran¹, A. Suah¹, S. Khiew¹, J. Young¹, M. Andrade¹, J. Pollard¹, Q. Wang¹, D. Yin¹, G. Chalasani², M. Alegre¹, A. Chong¹
¹Department of General Surgery, University of Chicago, Chicago, IL, ²Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: There are ample clinical data that a major long-term consequence of pregnancy is humoral allosensitization. Paradoxically, pregnancy is also a state of spontaneous allogeneic…
2020 American Transplant Congress
Clinical Significance of Late Antibody-Mediated Rejection without Donor Specific Anti-hLA Antibodies
J. Lee¹, E. Kim¹, S. Yang¹, S. Kim¹, B. Lim², H. Choi³, B. Kim⁴, B. Kim⁴, M. Ju⁵, M. Kim¹, S. Kim¹, Y. Kim¹, K. Huh¹
¹Department of Transplantation Surgery, Severance Hospital, Seoul, Korea, Republic of, ²Department of Pathology, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Internal Medicine, Gangnam Severance Hospital, Seoul, Korea, Republic of, ⁴Department of Internal Medicine, Severance Hospital, Seoul, Korea, Republic of, ⁵Department of Surgery, Gangnam Severance Hospital, Seoul, Korea, Republic of
*Purpose: Late onset antibody-mediated rejection (AMR) is a leading cause of kidney allograft failure. Its diagnosis has been based on a combination of morphologic, immunohistologic…
2020 American Transplant Congress
Granulocyte Colony Stimulating Factor: Trigger of Rejection in Lung Transplantation?
K. Walter¹, M. Patti¹, S. Khalid², L. Kemp¹, L. J. Lobo³, R. Coakley³, S. Krishnan³, C. T. Doligalski¹
¹University of North Carolina Medical Center, Chapel Hill, NC, ²Eshelman School of Pharmacy, Chapel Hill, NC, ³Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
*Purpose: Granulocyte colony stimulating factor (GCSF) is a management strategy for post-transplant neutropenia, but may increase the risk of rejection in lung transplant recipients (LTRs).…
2020 American Transplant Congress
Safety and Efficacy of Low Dose Rabbit Antithymocyte Globulin in Pediatric Renal Transplant Recipients
V. K. Sigurjonsdottir¹, L. Maestretti¹, A. McGrath¹, A. Gallo², W. Concepcion², P. Grimm¹, A. Chaudhuri¹
¹Pediatric Nephrology, Stanford University, Stanford, CA, ²Surgery - Multi-Organ Transplantation, Stanford University, Stanford, CA
*Purpose: Currently there is no consensus among pediatric kidney transplant centers regarding the use and regimen for immunosuppressive induction therapy.The safety and effectiveness of reduced…
2020 American Transplant Congress
Uncovering Factors That Lead to an Increase in Significant Early Rejection Outcomes in Cardiac Transplant Patients
N. Parimi¹, J. Titterington²
¹Internal Medicine, University of Kansas Medical Center, Kansas City, KS, ²Cardiovascular Disease, University of Kansas Health System, Kansas City, KS
*Purpose: The factors that lead to an increase in significant early rejection (stage 2R or greater) along with the preferred induction immunosuppression strategy in orthotopic…