Articles tagged "Rejection"

2020 American Transplant Congress
Stability of T Reg with Combination of mTOR Inhibitors with Belatacept in Reducing Risk of Acute Rejection in Kidney Transplant
J. Shoji, J. Leung, Q. Tang, F. Vincenti
University of California San Francisco (UCSF), San Francisco, CA
*Purpose: Belatacept is a costimulatory blocker that is used as de novo maintenance immunosuppression in kidney transplantation to avoid toxic effects of calcineurin inhibitors and…
2020 American Transplant Congress
Multiplexed Imaging Mass Cytometry Analysis Reveals a New Role for CD68+ Macrophages in Chronic Liver Transplant Rejection
J. Emamaullee, C. Man, J. Hoeflich, N. Ung, R. Sun, N. Matasci, J. Katz, J. Lee, S. Chopra, L. Sher, S. Asgharzadeh, O. Akbari, Y. Genyk
University of Southern California, Los Angeles, CA
*Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Recently, a novel high-resolution mass spectrometry-based technique has been…
2020 American Transplant Congress
Apoptotic Exosome-Like Vesicles are Associated with Alloimmune Vascular Injury in Kidney Transplant Recipients
M. Dieude¹, E. Boilard², I. Allaeys², A. Deneault-Marchand¹, J. Turgeon¹, E. Dore², S. Lariviere-Beaudoin¹, A. Karakeussian-Rimbaud¹, S. Collette³, L. Senecal³, M. Hebert¹, H. Cardinal¹
¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, ²Centre de Recherche du Centre Hospitalier de l'Université de Québec, Quebec, QC, Canada, ³Hopital Maisonneuve-Rosemont, Montreal, QC, Canada
*Purpose: There is no non-invasive biomarker of alloimmune vascular injury. We have previously characterized exosome-like vesicles enriched in active proteasome and LG3 (ApoExo) that are…
2020 American Transplant Congress
Unusual Case of Delayed Onset Proteinuria in AT1R Antibody Mediated Rejection
K. Venkatachalam, L. Mackelaite, H. Dave
Nephrology and Hypertension, University of Louisville, Louisville, KY
*Purpose: Describing the nuances in treatment of Angiotensin receptor II Type I antibody mediated rejection*Methods: Complement-independent Angiotensin receptor II Type I antibodies (AT1R-Ab) have been…
2020 American Transplant Congress
Induction Immunosuppression with Thymoglobulin May Improve Graft Outcomes without Increasing a Risk for Infection in Patients Undergoing Liver Transplantation Alone
M. Henry¹, T. Kitajima², J. Konel¹, S. Yeddula², M. Rizzari², K. Collins², D. Moonka², A. Yoshida², M. Abouljoud², S. Nagai³
¹Wayne State University School of Medicine, Detroit, MI, ²Henry Ford Hospital, Detroit, MI, ³Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI
*Purpose: Immunosuppression protocols for liver transplant (LT) vary between institutions and roles of induction immunosuppression in LT remain controversial. The aim of this study was…
2020 American Transplant Congress
Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication During Cardiac Allograft Rejection in the Mouse Heart Transplantation
Y. Tang, X. Shi, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Allograft rejection is still the leading causes of the graft loss, especially long-term outcome. Single-cell genomics techniques are revolutionizing our ability to comprehensively characterize…
2020 American Transplant Congress
Yield and Utility of Surveillance Kidney Biopsies in Pediatric Kidney Transplant Recipients at Various Time Points Post-Transplant
A. Landsberg¹, M. Riazy², T. Blydt-Hansen¹
¹Nephrology, BC Children's Hospital, Vancouver, BC, Canada, ²Pathology and Laboratory Medicine, St. Paul's Hospital, Vancouver, BC, Canada
*Purpose: There lacks consensus regarding the appropriate timing of routine surveillance biopsies (SB) for pediatric kidney transplant recipients. We evaluated the yield of positive biopsy…
2020 American Transplant Congress
A Comprehensive Evaluation of Risk Factors for Pneumocystis Jiroveci Pneumonia in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis
N. Permpalung¹, V. Kittipibul², P. Mekraksakit³, P. Rattanawong⁴, S. Nematollahi¹, S. Mehta-Steinke¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²University of Miami/Jackson Memorial Hospital, Miami, FL, ³Texas Tech University Health Sciences, Lubbock, TX, ⁴Mayo Clinic, Phoenix, AZ
*Purpose: Pneumocytis jiroveci pneumonia (PJP) is an important opportunistic fungal infection in solid organ transplant (SOT) recipients that carries a significant morbidity and mortality. Several…
2020 American Transplant Congress
Assessment of the Usefulness of Urine Signature to Differentiate Acute Rejection in a Prospective Kidney Transplantation Cohort
J. Seo¹, S. Jung², J. Moon², K. Jeong³, C. Kim⁴, B. Chung⁵, J. Park⁶, Y. Kim⁷, S. Lee²
¹Department of Core Research Laboratory, Medical Science Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ²Department of Internal Medicine, Division of Nephrology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ³Department of Internal Medicine, Division of Nephrology, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, ⁴Department of Internal Medicine, Division of Nephrology, Kyung-pook National University School of Medicine, Daegu, Korea, Republic of, ⁵Department of Internal Medicine, Division of Nephrology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁶Department of Internal Medicine, Sungkyunkwan University, Samsung Hospital, College of Medicine, Seoul, Korea, Republic of, ⁷Department of Internal Medicine, Division of Nephrology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea, Republic of
*Purpose: Despite many biomarker studies in the field of transplantation, development and validation of noninvasive molecular assays to diagnose disease and monitor immune activity is…
2020 American Transplant Congress
Efficacy and Possible Risk of De Novo Use of Everolimus for Primary Kidney Transplantation
S. Narumi¹, Y. Watarai¹, N. Goto², T. Hiramtsu¹, M. Okada¹, K. Futamura², T. Tomosugi¹, A. Kanda², T. Kobayashi³
¹Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya City, Aichi Prefecture, Japan, ²Transplant Nephrology, Nagoya Daini Red Cross Hospital, Nagoya City, Aichi Prefecture, Japan, ³Transplant Surgery, Aichi Medical University School of Medicine, Nagakute City, Aichi Prefecture, Japan
*Purpose: Transplant outcome and protocol stay rate of everolimus were investigated to clarify efficacy and risk of everolimus based regimens at a single institute.*Methods: During…