2020 American Transplant Congress
Proteomic Profiling of Circulating Extracellular Vesicles Isolated from Human Lung Transplant Recipients
*Purpose: Circulating exosomes in human lung transplant recipients (LTxRs) with acute (AR) and chronic rejection (bronchiolitis obliterans syndrome [BOS]) contain donor human leukocyte antigen (HLA)…2020 American Transplant Congress
Thymoglobulin Dose and Incidence of Biopsy Proven Acute Rejections in the Early Post Transplant Period
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Optimal dosing of thymoglobulin (ATG) for induction has not been well defined. Our protocol aims for 5-6mg/kg cumulative dose divided over 4 doses. However,…2020 American Transplant Congress
Molecular Diagnosis of Rejection in Liver Transplant Biopsies: The INTERLIVER Study
*Purpose: Diagnosing rejection in liver transplant biopsies is challenging given the limitations of histology e.g. low kappa values among pathologists. A Molecular Microscope® Diagnostic system…2020 American Transplant Congress
Ion AmpliSeq RNA Expression Panel Evaluated by Next-Generation Sequencing (NGS) Can Detect Genes in Human Formalin-Fixed Paraffin-Embedded Kidney Biopsies to Predict T Cell and Antibody Mediated Rejection in Renal Allografts
1Surgery, University of Miami, Miami, FL, 2University of Miami, Miami, FL
*Purpose: Optimization of effective anti-rejection therapies to prevent allograft rejection and to minimize drug toxicity may be aided by utilizing in situ biomarkers for detection…2020 American Transplant Congress
Significance of DSA Clearance in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients on 1 Year Outcomes: Interim Results from PARAMOUr “Pediatric Renal AMr Outcomes” Study
*Purpose: Little is known about how donor specific antibody (DSA) clearance correlates with outcomes in pediatric antibody mediated rejection (AMR). There is also little data…2020 American Transplant Congress
Development and Impact of DSA after Lung Transplant
*Purpose: Antibody-mediated rejection (AMR) after lung transplant (LT) is a serious complication, potentially leading to graft failure despite advances in drug therapy. Diagnosis and treatment…2020 American Transplant Congress
The Potential Significance of ABO Genotyping for Donor Selection in Kidney Transplantation
*Purpose: The ABO blood group system is clinically important in kidney transplantation, but ABO genotyping fails to attract sufficient attention in China. We identified one…2020 American Transplant Congress
Management of Adenovirus Enteritis after Intestinal Transplantation
*Purpose: Solid organ transplant recipients are at risk for infection, in part due to immunosuppression. Adenovirus enteritis (AE) is one possible clinical presentation of infection…2020 American Transplant Congress
Diagnostic Method of Acute Kidney Rejection after Transplantation Using Metabolome Analysis via a Liquid Biopsy Approach
*Purpose: At present, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy…2020 American Transplant Congress
Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection
*Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
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