Articles tagged "Rejection"

2020 American Transplant Congress
Clinical Significance of Late Antibody-Mediated Rejection without Donor Specific Anti-hLA Antibodies
J. Lee¹, E. Kim¹, S. Yang¹, S. Kim¹, B. Lim², H. Choi³, B. Kim⁴, B. Kim⁴, M. Ju⁵, M. Kim¹, S. Kim¹, Y. Kim¹, K. Huh¹
¹Department of Transplantation Surgery, Severance Hospital, Seoul, Korea, Republic of, ²Department of Pathology, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Internal Medicine, Gangnam Severance Hospital, Seoul, Korea, Republic of, ⁴Department of Internal Medicine, Severance Hospital, Seoul, Korea, Republic of, ⁵Department of Surgery, Gangnam Severance Hospital, Seoul, Korea, Republic of
*Purpose: Late onset antibody-mediated rejection (AMR) is a leading cause of kidney allograft failure. Its diagnosis has been based on a combination of morphologic, immunohistologic…
2020 American Transplant Congress
Granulocyte Colony Stimulating Factor: Trigger of Rejection in Lung Transplantation?
K. Walter¹, M. Patti¹, S. Khalid², L. Kemp¹, L. J. Lobo³, R. Coakley³, S. Krishnan³, C. T. Doligalski¹
¹University of North Carolina Medical Center, Chapel Hill, NC, ²Eshelman School of Pharmacy, Chapel Hill, NC, ³Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
*Purpose: Granulocyte colony stimulating factor (GCSF) is a management strategy for post-transplant neutropenia, but may increase the risk of rejection in lung transplant recipients (LTRs).…
2020 American Transplant Congress
Safety and Efficacy of Low Dose Rabbit Antithymocyte Globulin in Pediatric Renal Transplant Recipients
V. K. Sigurjonsdottir¹, L. Maestretti¹, A. McGrath¹, A. Gallo², W. Concepcion², P. Grimm¹, A. Chaudhuri¹
¹Pediatric Nephrology, Stanford University, Stanford, CA, ²Surgery - Multi-Organ Transplantation, Stanford University, Stanford, CA
*Purpose: Currently there is no consensus among pediatric kidney transplant centers regarding the use and regimen for immunosuppressive induction therapy.The safety and effectiveness of reduced…
2020 American Transplant Congress
Uncovering Factors That Lead to an Increase in Significant Early Rejection Outcomes in Cardiac Transplant Patients
N. Parimi¹, J. Titterington²
¹Internal Medicine, University of Kansas Medical Center, Kansas City, KS, ²Cardiovascular Disease, University of Kansas Health System, Kansas City, KS
*Purpose: The factors that lead to an increase in significant early rejection (stage 2R or greater) along with the preferred induction immunosuppression strategy in orthotopic…
2020 American Transplant Congress
Blocking Complement Component C3 in a Sensitized Nonhuman Primate Model of Kidney Allotransplantation
R. Schmitz¹, P. M. Schroder¹, Z. W. Fitch¹, A. Y. Choi¹, M. Manook¹, J. Yoon¹, A. Farris², E. S. Reis³, J. D. Lambris³, J. Kwun¹, S. J. Knechtle¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Sensitized transplant recipients represent a challenge due to the presence of donor-specific antibodies (DSA), which increase the risk of antibody-mediated rejection. Complement inhibition has…
2020 American Transplant Congress
Monitoring Inflammatory Cytokines in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)
S. Ge¹, A. Petrosyan¹, M. Chu¹, N. Ammerman², A. Vo², X. Zhang³, S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ³HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Chronic inflammation and HLA sensitization are burdens for end stage renal disease Pts awaiting for a KTx. IL-6 is a pro-inflammatory cytokine responsible for…
2020 American Transplant Congress
Profiling Non-HLA Antibodies in Antibody-Mediated Rejection Following Cardiac Transplantation
S. B. See¹, B. S. Mantell², K. J. Clerkin³, B. Ray⁴, E. R. Vasilescu⁵, C. Marboe⁵, Y. Naka⁶, S. Restaino³, P. C. Colombo³, L. Addonizio², M. A. Farr³, E. Zorn¹
¹Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, ²Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, ³Department of Medicine, Columbia University Irving Medical Center, New York, NY, ⁴Research and Development, Immucor, Waukesha, WI, ⁵Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, ⁶Department of Surgery, Columbia University Irving Medical Center, New York, NY
*Purpose: Antibody-mediated rejection (AMR) driven by the development of donor-specific antibodies (DSA) directed against mismatched donor HLA is a major risk factor for graft loss…
2020 American Transplant Congress
Intimal Arteritis in Association with Microvascular Inflammation Leads to Inferior Graft Survival Regardless DSA
M. Novotny¹, E. Honsova², O. Viklicky¹
¹Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Intimal arteritis belongs between diagnostic criteria of both antibody-mediated rejection (AMR) and T cell-mediated vascular rejection (TCMRV). Patients with intimal arteritis must be assessed…
2020 American Transplant Congress
Circulatory Extracellular Vesicles from Lung Allograft Recipients with Chronic Lung Allograft Dysfunction Can Induce LKB1 Dependent Epithelial-Mesenchymal Transition
M. Rahman, S. Angara, A. Arjuna, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Extracellular vesicles (EVs) play important role in physiological and pathological conditions. Recently we demonstrated that circulating exosomes (EVs) with lung self-antigens (SAgs) play important…
2020 American Transplant Congress
Automated Monitoring of Four Urinary Biomarkers in Routine Surveillance Identifies Patients at Low and High Risk of Renal Allograft Injury
L. Sheward¹, J. Wedel¹, N. Rodig¹, R. Mannon², O. Bestard³, V. Dharnidharka⁴, D. Zurakowski¹, A. Kho¹, T. Blydt-Hansen⁵, M. Seifert², D. M. Briscoe¹
¹Boston Children's Hospital, Boston, MA, ²University of Alabama at Birmingham, Birmingham, AL, ³Bellvitge University Hospital, Barcelona, Spain, ⁴St Louis Children's Hospital, St Louis, MO, ⁵BC Children's Hospital, Vancouver, BC, Canada
*Purpose: Surveillance renal biopsy data indicate that up to 36% of clinically stable kidney allograft recipients have subclinical rejection, emphasizing the need to implement automated…