Articles tagged "Rejection"

2021 American Transplant Congress
Impact of Donor and Recipient Age Difference: Outcomes within the First Year of Orthotopic Heart Transplant
M. Mascetti, M. Manson, Z. Truman
Baylor St. Luke's Medical Center, Houston, TX
*Purpose: In recent history, the number of patients listed as eligible to receive a heart transplant has increased by nearly 40%. However, not all hearts…
2021 American Transplant Congress
Obesity Impacts Acute Rejection but Not Allograft Function Improvement in the Setting of Belatacept Conversion
D. Pierce, J. Benken, P. West-Thielke, I. Tzvetanov, E. Benedetti, A. Lichvar
University of Illinois at Chicago, Chicago, IL
*Purpose: There is limited data regarding belatacept conversion in obese patients as an alternative to calcineurin inhibitor (CNI) immunosuppression. Pharmacokinetic (PK) data suggests increasing clearance…
2021 American Transplant Congress
Membrane versus Centrifuge‑Based Therapeutic Plasma Exchange to Treat Antibody-Mediated Rejection in Kidney Transplantation
P. Maggiani¹, J. C. Ramirez Valdestino¹, J. H. Cano Cervantes¹, O. D. Díaz Avedaño¹, G. García Castillo¹, M. C. Oseguera Vizcaíno², M. A. Covarrubias², M. Matías Carmona¹, D. F. Ovando Morga¹, G. Ramirez Ramirez¹, V. D. Lebrija Córdoba¹, S. Hernandez Estrada¹
¹Transplantation, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico, ²Transplantation, Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico
*Purpose: Therapeutic plasma exchange (TPE) is either performed using a highly permeable filter with standard multifunctional renal replacement equipment (mTPE) or a centrifugation device (cTPE).…
2021 American Transplant Congress
Pilot Evaluation of Prognosis After Liver Transplantation in Patients with a History of Hepatocellular Carcinoma and Pd-1 Inhibition
M. Chen¹, Z. Chen¹, X. Lin²
¹First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²the Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: The successful applications of programmed death protein-1 (PD-1) inhibitors in cancer therapy has led to an expanding use of immunotherapy in oncolog Liver transplantation…
2020 American Transplant Congress
Long Term Graft Outcome after Subclinical Banff Borderline Changes Suspicious for Acute T Cell-Mediated Rejection
A. Han, H. Ko, C. Chung, H. Kim, S. Min, J. Ha
Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Long term data after Banff borderline changes suspicious for acute T cell-mediated rejection (BDR lesion) are scarce, and hence, there is little evidence to…
2020 American Transplant Congress
Single Cell Profiling of PBMC Identifies Immune Populations Associated with High Risk of Early Acute Rejection
W. Zhang, S. Farouk, Z. Sun, W. Huang, Z. Yi, J. Fu, C. Wei, M. Fribourg-Casajuana, C. He, P. Cravedi, B. Murphy
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Our previous transcriptomic analysis of pre-transplant peripheral blood revealed a 23-gene set predictive of early acute rejection (EAR) post kidney transplant (JCI Insight, 2019).…
2020 American Transplant Congress
Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression
T. Sigdel, A. Schroeder, J. Y. Yang, R. Sarwal, J. Liberto, M. Sarwal
University of California San Francisco, San Francisco, CA
*Purpose: The purpose of this study was to apply high-throughput metabolomics and machine learning to identify surrogate urine metabolite biomarkers for acute rejection vs. BK…
2020 American Transplant Congress
Molecular Diagnosis and Risk Prediction in BK Virus Nephropathy: Discovery and Multicenter Validation of Novel Intragraft Gene Expression Signatures
B. Adam¹, Z. Kikic², Y. Bouatou³, J. Gueguen³, B. Robin³, G. Reid¹, H. Regele², M. Rabant³, A. Loupy³, M. Mengel¹
¹University of Alberta, Edmonton, AB, Canada, ²Medical University of Vienna, Vienna, Austria, ³Paris Transplant Group, Paris, France
*Purpose: Novel tools are needed to improve diagnosis and risk prediction in BK virus nephropathy (BKVN). This study aimed to assess the utility of intragraft…
2020 American Transplant Congress
The Clinical Usefulness of Preformed C1q-Binding Donor-Specific Antibodies in Kidney Transplantation
S. Lee, E. Ko, B. Chung, C. Yang
Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: The anti-human leukocyte antigen (HLA) antibodies are well known for risk factor of rejection or allograft loss. Additionally, de novo complement component 1q-binding donor-specific…
2020 American Transplant Congress
Significance of Pathology in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients on 1 Year Outcomes: Interim Results of the Paramour “Pediatric Renal AMR Outcomes” Study
I. Ashoor¹, A. Jain², R. Garro³, M. Kallash⁴, S. Soloman⁵, K. Twombley⁶
¹LSUHSC and Children's Hospital New Orleans, New Orleans, LA, ²Children's Hospital of Michigan, Detroit, MI, ³Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA, ⁴Nationwide Children's Hospital, Columbus, OH, ⁵Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, ⁶Medical University of South Carolina, Charleston, SC
*Purpose: Little is known about how pathology findings on biopsy correlate with outcomes in pediatric kidney transplant patients with antibody mediated rejection (AMR). We aimed…