Articles tagged "Rejection"

2021 American Transplant Congress
Kidney Transplant Survival After Borderline Rejection in the Setting of Denovo Dsa Formation
A. P. Bregman¹, S. Jackson², S. Riad¹
¹Department of Nephrology, University of Minnesota, Minneapolis, MN, ²Biostatistics, M-Health Fairview Analytics, Minneapolis, MN
*Purpose: The significance of borderline cellular rejection has been questioned in the past. Data on borderline rejection with deNovo DSA (dnDSA) formation is limited. We…
2021 American Transplant Congress
Plasma Donor-Derived Cell-Free DNA Levels Risk-Stratify Kidney Allograft Injury with Isolated Transplant Glomerulitis
L. Bu¹, S. Anand², A. Pai³, J. S. Bromberg⁴, G. Gupta⁵, I. Moinuddin⁵, T. Alhamad⁶, V. Bowers⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹
¹University of Minnesota, Minneapolis, MN, ²Intermountain Medical Center, Murray, UT, ³University of Texas McGovern Medical School, Houston, TX, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Virginia Commonwealth University, Richmond, VA, ⁶Washington University in St. Louis, St. Louis, MO, ⁷Tampa General Hospital, Tampa, FL, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: The Banff lesion Glomerulitis (g) characterizes the degree of microvascular glomerular inflammation. Some studies have demonstrated glomerulitis in the absence of C4d in association…
2021 American Transplant Congress
Treatment of Refractory Chronic Active Antibody-Mediated Rejection: Improvement in Histopathology are Delayed Compared to the Reduction in Donor Specific Antibodies
K. R. Degner¹, S. Parajuli¹, F. Aziz¹, N. Garg¹, M. Mohamed¹, D. A. Mandelbrot¹, S. E. Panzer¹, L. Hidalgo¹, N. A. Wilson¹, S. R. Reese¹, K. Van Hyfte¹, W. Zhong¹, P. Nickerson², A. Djamali¹
¹University of Wisconsin, Madison, WI, ²University of Manitoba, Winnipeg, MB, Canada
*Purpose: There are limited options for the treatment and management of refractory chronic active antibody-mediated rejection (cABMR) after kidney transplantation. Longitudinal histologic data in patients…
2021 American Transplant Congress
Quality Improvement Surveillance by Machine Learning
J. D. Perkins¹, E. Clemens², M. Granich³, J. Yeung³, J. Reyes¹
¹Surgery, University of Washington, Seattle, WA, ²Pharmacy, University of Washington, Seattle, WA, ³Center of Clinical Excellence, University of Washington, Seattle, WA
*Purpose: The purpose of this quality study was to compare our newly developed natural language processing (NLP) machine learning surveillance algorithm in detecting the rate…
2020 American Transplant Congress
Molecular Profiles of Injury in Heart Transplant Allograft: Relationship to Rejection, Ejection Fraction, and Survival
P. Halloran¹, J. Reeve², &. the INTERHEART Study Group³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: In previous studies we used microarray analysis of gene expression to identify rejection in heart transplant endomyocardial biopsies, and found that this also revealed…
2020 American Transplant Congress
Donor Derived Cell Free DNA (dd-cfDNA) and Gene Expression Signatures of Antibody-Mediated Rejection (ABMR) May Improve Accuracy of ABMR Diagnosis (Dx)
H. Zhang¹, C. C. Nast², E. Huang³, N. Ammerman³, A. A. Vo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Dd-cfDNA has a clinically meaningful association with early Dx of ABMR. Here, we evaluated dd-cfDNA measured prior to for-cause biopsies (Bx), and also measured…
2020 American Transplant Congress
Analysis of Rejection, Rejection Therapy and Renal Function in the BEST Trial
H. Kuzaro¹, A. R. Shields², A. Wiseman³, S. Tremblay¹, A. Christianson¹, D. Kaufman⁴, J. Leone⁵, A. Matas⁶, P. West-Thielke⁷, R. R. Alloway¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH, ³U Colorado, Denver, CO, ⁴U Wisconsin, Madison, WI, ⁵Tampa General, Tampa, FL, ⁶U Minnesota, Minneapolis, MN, ⁷UIC, Chicago, IL
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal) compared two belatacept (BELA)-based early corticosteroid withdrawal (ESW) regimens and alemtuzumab (ALEM) or rabbit antithymocyte globulin (rATG)…
2020 American Transplant Congress
Evaluation of the Safety and Tolerability of Clazakizumab® as a Desensitization Agent in Highly-HLA Sensitized ESRD Patients (NCT03380962): 12m Follow-Up
A. A. Vo¹, N. Ammerman¹, E. Huang¹, M. Toyoda², S. Ge², A. Peng¹, R. Najjar¹, S. Williamson¹, C. Meyers¹, S. Sethi¹, K. Lim¹, J. Choi¹, S. C. Jordan¹
¹Kidney Transplant, Cedars Sinai Medical Ctr, Los Angeles, CA, ²Transplant Immunology Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6 mediates inflammation and activation of T-cells, B-cells & plasma cells. Thus, IL-6 may represent an important target for desensitization (DES). Here we report…
2020 American Transplant Congress
Glomerulitis in One-Hour Biopsy after ABO-Blood Type Incompatible Kidney Transplantation Sensitively Suggests Occurrence of Antibody-Mediated Rejection
D. Iwami, K. Hotta, N. Iwahara, N. Shinohara
Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
*Purpose: Antibody-mediated rejection (ABMR) after ABO-blood type-incompatible kidney transplantation (ABOi-KTx) can affect transplant outcome even lead to allograft loss unless promptly diagnosed and adequately treated.…
2020 American Transplant Congress
Peripheral Blood T- and B-Cells as Predictors of Acute Rejection in Pancreas Transplant Recipients
P. Ventura Aguiar¹, J. Rovira², M. Ramirez-Bajo², E. Bañón-Maneus², N. Hierro², M. Garcia Criado³, M. Cuatrecasas⁴, J. Ferrer⁵, E. Esmatjes⁶, J. Campistol¹, F. Diekmann¹
¹Nephrology and Kidney Transplantation, Hospital Clinic Barcelona, Barcelona, Spain, ²Laboratori Experimental de Nefrologia i Trasplantament, Fundacio Clinic - IDIBAPS, Barcelona, Spain, ³Radiology Department, Hospital Clinic Barcelona, Barcelona, Spain, ⁴Pathology Department, Hospital Clinic Barcelona, Barcelona, Spain, ⁵HepatoBilioPancreatic Surgery Department, Hospital Clinic Barcelona, Barcelona, Spain, ⁶Endocrinology Department, Hospital Clinic Barcelona, Barcelona, Spain
*Purpose: Pancreas transplantation is associated with a high risk of acute rejection. The effect of peripheral blood mononuclear cells (PBMC) on acute rejection (AR) outcomes…