Articles tagged "Rejection"

2021 American Transplant Congress
Donor-Derived Cell-Free DNA Can Differentiate Rejection versus Other Causes of Pancreas Transplant Dysfunction
N. Ali¹, J. Miles², Z. Stewart Lewis¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, CA
*Purpose: Assessment and early detection of allograft injury in simultaneous pancreas and kidney (SPK) transplant recipients has clear benefits for optimizing treatment and intervention. Donor-derived…
2021 American Transplant Congress
A Single Nucleotide Polymorphism within the FCGR3A 158 F/V Gene is Associated with Decreased Survival of Renal Allografts with Chronic Active Antibody-Mediated Rejection
N. H. Litjens, A. M. Peeters, J. A. Kal-van Gestel, M. Klepper, M. G. Betjes
Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Long-term allograft survival has shown little improvement over the last decades. An important factor compromising long-term allograft survival in kidney transplantation is chronic active…
2021 American Transplant Congress
Effects of Timing of Everolimus Transition on Renal Outcomes in Liver Transplant Recipients
M. Leick¹, H. Belleau², T. McCashland³
¹Nebraska Medicine, Omaha, NE, ²Bryan Health, Lincoln, NE, ³University of Nebraska Medical Center, Omaha, NE
*Purpose: The purpose of this study is to evaluate the effects of the timing of everolimus transition on renal outcomes in liver transplant recipients.*Methods: This…
2021 American Transplant Congress
Kidney Transplant Rejection Can Be Diagnosed or Even Predicted by Tracking Donor Reactive T Cell Clones in Post-transplant Samples
Y. Sambandam¹, M. Kandpal¹, J. He¹, X. Huang¹, T. S. Taylor¹, A. A. Shetty², J. M. Mathew¹, J. R. Leventhal¹
¹Surgery-Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine, Nephrology Division, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: To test if kidney transplant (KTx) rejection can be diagnosed by monitoring for donor reactive T-cell (DRTC) clones in post-transplant (post-tx) biopsy and non-invasively…
2021 American Transplant Congress
Low Socio-economic Status is Associated with Lower Kidney Graft Survival and Increased Risk of Graft Failure Due to Acute Rejection
W. Xie¹, G. Vrakas¹, S. H. Gray¹, A. Haririan², J. R. Scalea¹, J. S. Bromberg¹, D. G. Maluf¹, R. P. Meier¹
¹Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
*Purpose: Low socio-economic status (SES) has been shown to be associated with poor kidney graft outcomes. We aimed to characterize differences in high and low…
2021 American Transplant Congress
Is There a Role for Donor-Specific Antibody Testing in Simultaneous Liver-Kidney Transplantation? A Single Center Analysis of Outcomes
A. Das, A. Barbetta, D. Remulla, C. Goldbeck, T. Maw, J. Kim
University of Southern California, Los Angeles, CA
*Purpose: Simultaneous liver-kidney transplantation (SLKT) has grown exponentially since its conception in the 1960’s. The role for donor specific antibody (DSA) testing in SLKT is…
2021 American Transplant Congress
Anti-HLA-DP Antibodies Positive – A Retrospective Review of Outcomes in Renal Transplantation- Single Centre Experience
O. Piscoran¹, J. Worthington², R. Dhillon¹, T. Augustine¹, M. Picton¹, M. Morton¹, S. Bhutani¹
¹Urology, Renal and Transplantation, Manchester University NHS Foundation Trust, Manchester, United Kingdom, ²Transplantation Laboratory, Manchester University NHS Foundation Trust, Manchester, United Kingdom
*Purpose: Data on the role of HLA-DP antibodies on graft outcome is not precise. Studies suggested that the presence of donor-directed HLA-DP antibodies correlate with…
2021 American Transplant Congress
Comparison of Next Generation Sequencing Donor-derived Cell Free DNA Assay Utilizing Whole Genome Sequencing
N. Singh¹, M. S. Naseer¹, D. Aultman², H. Shokouh-Amiri², G. Zibari²
¹Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Circulating donor-derived cell free DNA (dd-cfDNA) is a non-invasive biomarker of kidney allograft injury with a high negative predictive value for ruling out acute…
2021 American Transplant Congress
Impact of Treatment of Subclinical Rejection at 2 Weeks After Kidney Transplantation, Compared by 1 Year Histologic Outcomes
O. Lee¹, K. Lee¹, J. Park¹, J. Lee², G. Kwon³, K. Kim⁴
¹Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Medicine, Samsung Medical Center, Seoul, Korea, Republic of, ³Pathology, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Biostatistics, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Subclinical rejection (SCR) is associated with chronic allograft nephropathy, which is the most common cause of allograft failure in kidney transplantation (KT). Therefore, early…
2021 American Transplant Congress
Utility of Donor-Derived Cell Free DNA for Detecting ABMR in Patients With AT1R Antibodies
S. Kant¹, D. Kumar², I. Moinuddin², T. Alhamad³, M. Haris³, J. Gray⁴, B. Dale⁴, M. Bettinotti¹, D. C. Brennan¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²VCU, Richmond, VA, ³Wash Univ, St. Louis, MO, ⁴CareDx, Brisbane, CA
*Purpose: The presence of angiotensin II type 1 receptor (AT1R) antibodies is associated with non-HLA active antibody mediated rejection (ABMR). The frequent co-existence of negative…