2021 American Transplant Congress
The Clinical Significance of Preformed Anti-HLA-DQ Donor-specific Antibodies on Allograft Outcomes in Kidney Transplantation
*Purpose: De-novo anti-HLA-DQ donor-specific antibody (DSA) has been identified as a risk factor for late graft dysfunction and graft loss in kidney transplantation (KT). The…2021 American Transplant Congress
Impact of Social Support, Social Circumstances and Distance from Transplant Center on Post Liver Transplant Outcomes: An Analysis from a Predominantly Rural U.S. Cohort
1University of Arkansas for Medical Sciences, Little Rock, AR, 2Henry Ford Hospital, Detroit, MI
*Purpose: Social support and social circumstances (SSSC) are critical yet less described entities in post-orthotopic liver transplant (OLT). We aimed to describe SSSC and correlate…2021 American Transplant Congress
Donor Derived Cell Free DNA Identifies Rejection in Simultaneous Pancreas Kidney Transplant Recipients
*Purpose: Increased level of donor-derived cell-free DNA (dd-cfDNA) has proven to be a sensitive marker for allograft rejection after solid organ transplant, particularly heart and…2021 American Transplant Congress
Long Term Safety and Efficacy of Tocilizumab (anti-il6r, Tcz) Therapy in the Treatment of Refractory Chronic Antibody Mediated Rejection (cabmr) in 25 Pediatric Renal Transplant Recipients
*Purpose: Development of de novo donor specific antibodies (DSA) post renal transplantation puts pediatric patients at risk for chronic Antibody Mediated Rejection (cABMR) and allograft…2021 American Transplant Congress
Among Patients with Pre-Transplant Donor-Specific Antibodies, the Disappearance of the Donor-Specific Antibodies at 3 Months is Not Associated with Less Rejection
University of Wisconsin, Madison, WI
*Purpose: The number of sensitized kidney transplant recipients (KTRs) are increasing on the waiting list. Some KTRs receive an organ in the presence of pretransplant…2021 American Transplant Congress
Development of Diagnosis Method of Acute Graft Rejection After Kidney Transplantation Using Metabolome Analysis by Liquid Biopsy Approach
*Purpose: Presently, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy procedure…2021 American Transplant Congress
Digital Spatial Mrna Profiling Reveals Distinct Endothelial Transcripts in Dsa+ and Dsa- Endarteritis in Kidney Allografts
*Purpose: Renal allograft biopsy transcript analysis is typically performed by microarray, which lacks spatial resolution. We initiated a systematic program using the NanoString GeoMx® Digital…2021 American Transplant Congress
Association Between Donor-Recipient Genetic Matching and Acute Rejection in Kidney Transplantation
*Purpose: In this study we carried out a genome-wide association study (GWAS) between donor-recipient matching scores at individual SNP level and Acute rejection (AR) in…2021 American Transplant Congress
Gene Expression Profiles Assessed by the Nanostring nCounter® Platform May Differentiate Different Types of Rejection, and Importantly, T-Cell Mediated Rejection from BK Virus Nephropathy
1University of Wisconsin, Madison, WI, 2CareDx, Inc., San Francisco, CA
*Purpose: Allograft biopsies are considered the gold standard for diagnosis and therapeutic guidance in kidney transplant recipients. Expanding current biopsy assessments to include gene expression…2021 American Transplant Congress
AlloMap Kidney Gene Expression Profiling Discriminates Rejection from Immuno-Quiescence in Renal Transplant Recipients
*Purpose: Assessment of immune activation is important when considering pathologies such as allograft rejection as well as potential interventions that may extend allograft survival. Optimizing…
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