2021 American Transplant Congress
Infection Rates in Heart Transplant Recipients With Combined Tacrolimus and Sirolimus at High versus Low Concentrations
Loyola University Medical Center, Maywood, IL
*Purpose: Assess the impact of tacrolimus-sirolimus (TAC/SRL) concentration on infection rate in heart transplant recipients (HTR).*Methods: A retrospective review of HTR on TAC/SRL for ≥…2021 American Transplant Congress
The Use of Donor Derived Cell Free DNA in Children to Monitor Therapy of Kidney Rejection
Oregon Health & Science Univ, Portland, OR
*Purpose: Elevated donor-derived cell-free DNA (dd-cfDNA) in the presence of HLA donor-specific antibodies (DSA) are shown to correlate with acute antibody-mediated rejection (AMR) in adult…2021 American Transplant Congress
De Novo Membranous Nephropathy Associated with Antibody-mediated Rejection in Renal Transplant Recipients
*Purpose: Membranous nephropathy (MN) is a rare autoimmune disease, with the potential to develop a persistent nephrotic syndrome and end-stage chronic renal disease in some…2021 American Transplant Congress
Post Pediatric Liver Transplant Immunosuppression: What’s the Caregivers’ Perspective?
*Purpose: For children with liver transplants (LT), achieving an “ideal outcome” is a balancing act: too little immunosuppression (IS) begets graft injury; too much IS…2021 American Transplant Congress
Peripheral Blood Inflammatory Chemokines Uncover Rejection in the Absence of Histological Lesions
*Purpose: Cytokines and chemokines play a critical role in the pathophysiology of allograft rejection, but the relation of peripheral blood cytokine expression profiles to clinical…2021 American Transplant Congress
The Impact of De Novo Dose-Adjustment Strategies with Tacrolimus XR (LCP-Tac) in Kidney Transplant Recipients
Medical University of South Carolina, Charleston, SC
*Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for the prophylaxis of rejection in de novo kidney transplant recipients. It provides less variable…2021 American Transplant Congress
Dna-pkcs Regulation of the Allogeneic Immune Response
University of Arkansas, Little Rock, AR
*Purpose: Organ transplantation is life-saving and continued investigations into immunological mechanisms that drive organ rejection are needed to improve immunosuppression therapies and prevent graft failure.…2021 American Transplant Congress
DSA Causes Mild Molecular ABMR-like Changes in Many Biopsies Not Diagnosed as Rejection
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada
*Purpose: In the multicenter study INTERCOMEX, we developed a microarray-based system (MMDx) for diagnosing antibody-mediated and T cell-mediated rejection (ABMR, TCMR) in kidney transplant biopsies…2021 American Transplant Congress
Ectopic Hepatocyte Transplantation Into the Lymph Nodes in a Fully Mismatched Allogeneic Dog Model Using Tacrolimus and Prednisone
*Purpose: Develop organogenesis through ectopic hepatocyte transplantation (HT) into the upper abdominal lymph nodes (LN).*Methods: Three groups of Mongrel dogs weighting between 25-35 kg (control…2021 American Transplant Congress
RNA Sequencing (RNAseq) Tissue Analysis Can Provide Early Warning Signals for Potential Intestinal Transplant Complications
*Purpose: A disrupted mucosal barrier in intestinal grafts can cause alloreactive complications such as rejection, inflammation and infection following intestinal transplantation (ITx). We hypothesize that…
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