ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2021 American Transplant Congress

    Development and Validation of a Novel Peripheral Blood Based Gene Signature for Acute Rejection Following Renal Transplantation

    D. Zhang, Y. Wang, X. Hu

    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

    *Purpose: The aim of this study is to utilize advanced machine learning methods to construct a peripheral blood-based gene signature for acute rejection following kidney…
  • 2021 American Transplant Congress

    Association Between HLA Class II and TLR4 Regulates HLA-II Stimulated P-selectin Expression and Monocyte Capture to Endothelial Cells

    Y. Jin, J. Nevarez-Mejia, E. F. Reed

    Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA

    *Purpose: Antibody-mediated rejection (AMR) is a major obstacle for long-term allograft survival. Donor specific HLA antibodies (DSA) contribute to the process of AMR by binding…
  • 2021 American Transplant Congress

    VP2 MRNA Distinguishes the Direct Injury and Inflammation Effects of Polyoma Virus (BK) Infection from the Cognate TCMR Response That Follows Immunosuppressive Minimization

    P. F. Halloran1, K. Famulski1, K. S. Madill-Thomsen1, G. Böhmig2, G. Gupta3, M. Myślak4, O. Viklicky5, &. the INTERCOMEX Study Group6

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Medical University of Vienna, Vienna, Austria, 3Virginia Commonwealth University, Richmond, VA, 4Pomeranian Medical University, Szczecin, Poland, 5Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 6., Edmonton, AB, Canada

    *Purpose: BK virus nephropathy (BKN) and T cell-mediated rejection (TCMR) are difficult to distinguish by histology but often coexist due to the necessity for immunosuppression…
  • 2021 American Transplant Congress

    The Trifecta Study: Calibrating Circulating Donor-Derived Cell-Free DNA at the Time of Indication Biopsies Against the Molecular Phenotype of the Biopsy Reveals a Prominent Association with NK Cell Genes

    P. Halloran1, Z. Demko2, A. Prewett2, J. Reeve1, P. Billings2

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Natera Inc., San Carlos, CA

    *Purpose: The international, multicenter, prospective Trifecta study was designed to calibrate dd-cfDNA% measurements in blood at the time of indication biopsy against the molecular characteristics…
  • 2021 American Transplant Congress

    Recipient Neutrophils Producing Myeloperoxidase Provoke Nk Cell and Monocyte/macrophage Activation During Acute Antibody-mediated Rejection of Kidney Allografts

    D. Ueda, S. Miyairi, K. Keslar, W. M. Baldwin, R. L. Fairchild

    Lerner Research Institute, Cleveland Clinic, Cleveland, OH

    *Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and mediate acute graft rejection. Acute…
  • 2021 American Transplant Congress

    Initial Experience with TrugrafTm Gene Expression Profile and TracTm Dd-cfdna Testing in Kidney Transplant Recipients Suggests Synergy and Enhanced Management within the First Year Post-transplant and Beyond

    V. Paramasivam, B. Greco, M. Germain

    Nephrology, Baystate Medical Center, Springfield, MA

    *Purpose: Non-invasive validated rejection biomarkers are now available to monitor kidney transplant patients (KTRs). Two such biomarkers are; TruGrafTM (TG) gene expression profile validated to…
  • 2021 American Transplant Congress

    Days of Delayed Graft Function and Its Impact on Graft Outcomes in Deceased Donor Kidney Transplant

    P. Budhiraja1, R. J. Butterfield2, S. S. Misra1, K. S. Reddy3, L. Kodali1, H. A. Khamash1, S. Nair1, G. K. Mour1, H. A. Chakkera1, C. C. Jadlowiec3, H. Janna1, R. L. Heilman1

    1Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ, 2Department of Statistics, Mayo Clinic Arizona, Phoenix, AZ, 3Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ

    *Purpose: There has been controversy regarding impact of delayed graft function (DGF) on risk of acute rejection and graft survival. This is likely due to…
  • 2021 American Transplant Congress

    Food Insecurity and Impact on Transplant Outcomes in Pediatric Kidney Transplant Recipients

    A. Moin, P. Verghese, R. Engen, D. Matossian

    Pediatric Nephrology, Lurie Children's Hospital, chicago, IL

    *Purpose: Food insecurity (FI), defined as inconsistent access to food or worry over shortage of food that prevents an active and healthy life, has not…
  • 2021 American Transplant Congress

    The Summarized Assessment of Endothelin a Receptors Expression in Renal Transplant Compartments is Associated with Antibody Mediated Rejection

    M. Banasik1, K. Nowanska1, P. Donizy2, K. Koscielska-Kasprzak3, S. Zmonarski1, M. Kuriata-Kordek1, A. Tukiendorf4, A. Hałoń2, D. Janczak5, M. Krajewska1

    1Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland, 2Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, Wroclaw, Poland, 3Research laboratory, Wroclaw Medical University, Wroclaw Medical University, Wroclaw, Poland, 4Department of Public Health, Wroclaw Medical University, Wroclaw, Poland, 5Department of General, Vascular and Transplant Surgery, Wroclaw Medical University, Wroclaw, Poland

    *Purpose: The presence of non-HLA anti-endothelin A receptor antibodies may be important in transplant injury but the expression of the endothelin A receptor (ETA receptor)…
  • 2021 American Transplant Congress

    Pathology of the Explanted Lungs and Surveillance Allograft Biopsy in 202 Lung Transplant Cases: Single Institution Experience

    S. Sathirareuangchai1, S. Moore1, Q. Cai1, L. De Las Casas1, J. Joerns2, J. Torrealba1

    1Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 2Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX

    *Purpose: This study correlates lung transplantation outcomes with pathologic diagnoses of explants and surveillance transbronchial allograft biopsies.*Methods: A retrospective IRB approved review of archival material…
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