2022 American Transplant Congress
Deep Phenotyping Methods Highlight Recipient-Derived CD16+ NK and CD16+ Monocyte Infiltration During Kidney Transplant Rejection
*Purpose: How the immune system participates to kidney transplant rejection has not been fully elucidated. Single-cell (sc) genomics techniques are revolutionizing our ability to characterize…2022 American Transplant Congress
Impact of ATG Dose Reduction on Kidney Transplant Outcomes During the Covid-19 Pandemic
*Purpose: During the COVID-19 pandemic, many transplant centers modified induction immunosuppression regimens. Beginning December 2020, our center reduced anti-thymocyte globulin (ATG) protocol dosing by up…2022 American Transplant Congress
Circulating and Intragraft Donor (HLA)-Specific B Cells Drive Allograft Rejection After Kidney Transplantation
*Purpose: Besides donor-specific antibodies (DSA), circulating donor(HLA)-specific memory B cells (mBc) have also shown to play a deleterious role driving antibody-mediated rejection (ABMR) in kidney…2022 American Transplant Congress
Urinary Cell mRNA Profile Diagnosis of Borderline TCMR in Kidney Allografts
1Nephrology, Weill Cornell-NYPH, New York, NY, 2Pathology, Weill Cornell-NYPH, New York, NY
*Purpose: Borderline T cell-mediated rejection (BR) is associated with inferior outcomes. In the multicenter CTOT-04 study, we discovered and validated a urinary cell three-gene signature…2022 American Transplant Congress
Modern Medicine Needs Modern Technology Tools
Ochsner Foundation Hospital, New Orleans, LA
*Purpose: Dd-cfDNA has been used as a non-invasive biomarker for allograft injury and has been shown to detect subclinical rejection with higher predictive power compare…2022 American Transplant Congress
Can dd-cf DNA Eliminate Unnecessary Biopsies? The Answer is Yes!
University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Historically our center has been one that routinely performs biopsies. We perform them pre-perfusion, for slowly recovering allografts between day 10-14, and routinely at…2022 American Transplant Congress
Optimizing Kidney Transplant Immunosuppression Using a Phenotypic Personalized Dosing Model
*Purpose: Immunosuppression is essential for preventing rejection and promoting long-term graft survival following solid organ transplantation; it also places patients at risk for infection and…2022 American Transplant Congress
Baseline Levels and Early Post-Transplant Kinetics of Donor-Derived Cell-Free DNA Following Liver Transplantation
*Purpose: Non-invasive biomarkers in liver transplant (LT) are needed to improve detection of allograft injury in routine surveillance and during immunosuppression modulation, prior to the…2022 American Transplant Congress
Early Experience with OmniGraf® Biomarker Surveillance in Kidney Transplant Patients in the First-Year Post-Transplant and Beyond
*Purpose: Non-invasive rejection biomarkers continue to evolve with recent data supporting the use of combined gene expression and donor derived cell-free DNA (dd-cfDNA) in kidney…2022 American Transplant Congress
Evaluation of the Significance of Isolated C4d Staining without Histological Evidence of Rejection on Kidney Biopsies After ABO-Compatible Transplantation in Pediatric Recipients
*Purpose: C4d staining in peritubular capillaries has been part of ABMR Banff definition since 2003. Despite relatively high specificity, c4d staining shows limited sensitivity, and…
American Transplant Congress abstracts