ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2022 American Transplant Congress

    Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)

    M. R. Weir1, D. Mandelbrot2, J. S. Bromberg1, S. Mehta3, E. Poggio4, E. Huang5, G. Shekhtman6, N. Agrawal7, W. Tian8, M. Cooper9

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Wisconsin, Madison, WI, 3University of Alabama, Birmingham, AL, 4Cleveland Clinic, Cleveland, OH, 5Cedars-Sinai Medical Center, Los Angeles, CA, 6CareDx Inc., Brisbane, CA, 7CareDx Inc, Brisbane, CA, 8CareDx, Brisbane, CA, 9MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…
  • 2022 American Transplant Congress

    Conversion from Immediate to Extended-Release Tacrolimus (LCP-Tac) Six Months After Renal Transplantation Optimizes Safety and Efficacy

    S. P. Patel, F. Bartlett, T. Sprague, J. Newman, E. Andrade, N. Rao, N. Patel, D. Dubay, V. Rohan, M. Casey, D. Taber

    MUSC Health, Charleston, SC

    *Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for prevention of rejection in kidney transplant recipients (KTRs) that may have less variability and…
  • 2022 American Transplant Congress

    Galectin-3 is Predictive of 30-Day Acute Rejection Following Liver Transplantation

    D. Yoeli, T. Ferrell, I. Rodriguez, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, R. Choudhury, M. Adams, T. Nydam, E. Pomfret, C. Huang, H. Moore, N. Navarro Alvarez

    University of Colorado Anschutz Medical, Aurora, CO

    *Purpose: Galectin-3 (Gal3) is a beta-galactoside binding lectin that plays a key role in inflammation and immune response. Studies on Gal3 in liver transplantation are…
  • 2022 American Transplant Congress

    Rhinovirus Infection in Solid Organ Transplant Recipients

    G. Motoa1, M. A. Mendoza1, M. Raja1, J. Simkins2, S. Anjan2, E. Martin2, A. Phancao2, N. Sinha2, L. Abbo1, G. Guerra2, Y. Natori2

    1Jackson Memorial Hospital / University of Miami, Miami, FL, 2Miami Transplant Institute – University of Miami, Miami, FL

    *Purpose: Respiratory viral infections are one of the most common infections in solid organ transplant recipients (SOTR), causing significant morbidity and mortality. Limited data is…
  • 2022 American Transplant Congress

    The Role Of Combined Gene Expression Profiling And Donor-derived Cell-free Dna In Differentiating Acute Rejection In Liver Transplant Recipients

    S. Park1, M. Kandpal2, K. Guo2, S. Kleiboeker3, R. Sinha4, M. Abecassis5, J. Levitsky6

    1Transplant nephrology, Northwestern University, Chicago, IL, 2Northwestern University, Chicago, IL, 3Eurofins Viracor, Lee's Summit, MO, 4Eurofins Viracor, Lee's summit, MO, 5University of Arizona, Tucson, AZ, 6Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: In our previous studies, blood-based gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) have been independently validated in liver transplant recipients (LTR) to…
  • 2022 American Transplant Congress

    De Novo Focal Segmental Glomerulosclerosis in the Kidney Allograft: Association with Alloimmunity Leading to Poor Outcome

    J. Leon1, J. Duong Van Huyen2, A. Abderrahmane1, D. Anglicheau1, C. Legendre1, M. Rabant2

    1KIDNEY TRANSPLANTATION, Necker Hospital, Paris, France, 2KIDNEY PATHOLOGY, Necker Hospital, Paris, France

    *Purpose: Focal Segmental Glomerulosclerosis (FSGS) can be found de novo (Dn) or as a recurrence in kidney allograft. While FSGS recurrence has been extensively described…
  • 2022 American Transplant Congress

    Immunosuppressant Medications Use in Patients with Transplant Failure: A Canadian Multi-Centre Prospective Study

    G. Knoll1, M. Chassé2, D. Fergusson3, A. A. House4, O. Johnston5, R. Mainra6, D. Baran7, D. Treleaven8, l. senecal9, L. Tibbles10, M. Hebert11, M. Karpinski12, T. Campbell13, T. Ramsay14, J. Kim15, I. Houde16, C. White17, J. Perl15, P. Karnabi18, J. Gill5

    1Nephrology, Ottawa Hospital Research Institute, Ottawa, ON, Canada, 2University of Montreal, Montreal, QC, Canada, 3Ottawa Hospital Research Institute, Ottawa, ON, Canada, 4Nephrology, Western University, London, ON, Canada, 5Nephrology, University of British Columbia, Vancouver, BC, Canada, 6Nephrology, University of Saskatchewan, Saskatoon, SK, Canada, 7Nephrology, McGill University, Montreal, QC, Canada, 8Nephrology, McMaster University, Hamilton, ON, Canada, 9Nephrology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada, 10Nephrology, University of Calgary, Calgary, AB, Canada, 11Nephrology, University of Montreal, Montreal, QC, Canada, 12Nephrology, University of Manitoba, Winnipeg, MB, Canada, 13University of Alberta, Alberta, AB, Canada, 14Ottawa Hospital Research Institute, Ottawa, ON, Canada, 15University of Toronto, Toronto, ON, Canada, 16Laval University, Que´bec, QC, Canada, 17Queen's University, Kingston, ON, Canada, 18Ottawa Health Research Institute, Ottawa, ON, Canada

    *Purpose: This prospective study determined the association of immunosuppressant medication use with the outcomes of death, hospitalized infection, rejection of the failed allograft, and panel…
  • 2022 American Transplant Congress

    Effect of Covid-19 Vaccination on Markers of Rejection in Heart Transplant Recipients

    Z. Pieters1, E. Bruno1, S. Kim1, S. De Sirkar1, M. Thomas1, S. B. Sharmin2, M. Liebo1, A. Heroux1, N. Clark1, G. Reid1, S. Uprichard2, M. Yu1

    1Medicine, Loyola University Medical Center, Maywood, IL, 2Loyola University Chicago, Chicago, IL

    *Purpose: Heart transplant recipients have worse survival with COVID-19 than the general population, highlighting the importance of vaccination in these patients. The impact of vaccination…
  • 2022 American Transplant Congress

    Complete and High-Resolution HLA Typing Improves the Accuracy of Post-Transplant Assessment of De Novo Anti-Donor Immune-Mediated Events

    M. Meneghini1, A. Perona2, E. Crespo3, F. J. Bemelman4, P. M. Reinke5, O. Viklicky6, M. Giral7, O. Bestard1

    1Vall d'Hebron University Hospital, Barcelona, Spain, 2Universitat de Barcelona, Barcelona, Spain, 3Nephrology and Transplantation Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, 4Amsterdam University Medical Centers, Amsterdam, Netherlands, 5Charité Universitätsmedizin, Berlin, Germany, 6Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, 7Nantes Université, Inserm, CHU Nantes, Nantes, France

    *Purpose: High-resolution (HR) HLA typing using NGS technology has shown to improve the accuracy of assessing donor-recipient compatibility and characterization of pre-transplant anti HLA antibodies…
  • 2022 American Transplant Congress

    Is Pathologic AMR Grading Scale Associated with the Presence of Donor-Specific Antibodies?

    S. Kim, J. Patel, M. Kittleson, T. Singer-Englar, N. Patel, D. Chang, E. Kransdorf, D. Emerson, J. A. Kobashigawa

    Cedars-Sinai Smidt Heart Institute, Los Angeles, CA

    *Purpose: Antibody-mediated rejection (AMR) has been defined by an expert pathology group in 2011 which resulted in the ISHLT pathologic AMR (pAMR) grading scale. The…
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