Articles tagged "Rejection"

2022 American Transplant Congress
Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)
M. R. Weir¹, D. Mandelbrot², J. S. Bromberg¹, S. Mehta³, E. Poggio⁴, E. Huang⁵, G. Shekhtman⁶, N. Agrawal⁷, W. Tian⁸, M. Cooper⁹
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Wisconsin, Madison, WI, ³University of Alabama, Birmingham, AL, ⁴Cleveland Clinic, Cleveland, OH, ⁵Cedars-Sinai Medical Center, Los Angeles, CA, ⁶CareDx Inc., Brisbane, CA, ⁷CareDx Inc, Brisbane, CA, ⁸CareDx, Brisbane, CA, ⁹MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…
2022 American Transplant Congress
Conversion from Immediate to Extended-Release Tacrolimus (LCP-Tac) Six Months After Renal Transplantation Optimizes Safety and Efficacy
S. P. Patel, F. Bartlett, T. Sprague, J. Newman, E. Andrade, N. Rao, N. Patel, D. Dubay, V. Rohan, M. Casey, D. Taber
MUSC Health, Charleston, SC
*Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for prevention of rejection in kidney transplant recipients (KTRs) that may have less variability and…
2022 American Transplant Congress
Galectin-3 is Predictive of 30-Day Acute Rejection Following Liver Transplantation
D. Yoeli, T. Ferrell, I. Rodriguez, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, R. Choudhury, M. Adams, T. Nydam, E. Pomfret, C. Huang, H. Moore, N. Navarro Alvarez
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: Galectin-3 (Gal3) is a beta-galactoside binding lectin that plays a key role in inflammation and immune response. Studies on Gal3 in liver transplantation are…
2022 American Transplant Congress
Rhinovirus Infection in Solid Organ Transplant Recipients
G. Motoa¹, M. A. Mendoza¹, M. Raja¹, J. Simkins², S. Anjan², E. Martin², A. Phancao², N. Sinha², L. Abbo¹, G. Guerra², Y. Natori²
¹Jackson Memorial Hospital / University of Miami, Miami, FL, ²Miami Transplant Institute – University of Miami, Miami, FL
*Purpose: Respiratory viral infections are one of the most common infections in solid organ transplant recipients (SOTR), causing significant morbidity and mortality. Limited data is…
2022 American Transplant Congress
The Role Of Combined Gene Expression Profiling And Donor-derived Cell-free Dna In Differentiating Acute Rejection In Liver Transplant Recipients
S. Park¹, M. Kandpal², K. Guo², S. Kleiboeker³, R. Sinha⁴, M. Abecassis⁵, J. Levitsky⁶
¹Transplant nephrology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Eurofins Viracor, Lee's Summit, MO, ⁴Eurofins Viracor, Lee's summit, MO, ⁵University of Arizona, Tucson, AZ, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: In our previous studies, blood-based gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) have been independently validated in liver transplant recipients (LTR) to…
2022 American Transplant Congress
De Novo Focal Segmental Glomerulosclerosis in the Kidney Allograft: Association with Alloimmunity Leading to Poor Outcome
J. Leon¹, J. Duong Van Huyen², A. Abderrahmane¹, D. Anglicheau¹, C. Legendre¹, M. Rabant²
¹KIDNEY TRANSPLANTATION, Necker Hospital, Paris, France, ²KIDNEY PATHOLOGY, Necker Hospital, Paris, France
*Purpose: Focal Segmental Glomerulosclerosis (FSGS) can be found de novo (Dn) or as a recurrence in kidney allograft. While FSGS recurrence has been extensively described…
2022 American Transplant Congress
Immunosuppressant Medications Use in Patients with Transplant Failure: A Canadian Multi-Centre Prospective Study
G. Knoll¹, M. Chassé², D. Fergusson³, A. A. House⁴, O. Johnston⁵, R. Mainra⁶, D. Baran⁷, D. Treleaven⁸, l. senecal⁹, L. Tibbles¹⁰, M. Hebert¹¹, M. Karpinski¹², T. Campbell¹³, T. Ramsay¹⁴, J. Kim¹⁵, I. Houde¹⁶, C. White¹⁷, J. Perl¹⁵, P. Karnabi¹⁸, J. Gill⁵
¹Nephrology, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ²University of Montreal, Montreal, QC, Canada, ³Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴Nephrology, Western University, London, ON, Canada, ⁵Nephrology, University of British Columbia, Vancouver, BC, Canada, ⁶Nephrology, University of Saskatchewan, Saskatoon, SK, Canada, ⁷Nephrology, McGill University, Montreal, QC, Canada, ⁸Nephrology, McMaster University, Hamilton, ON, Canada, ⁹Nephrology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada, ¹⁰Nephrology, University of Calgary, Calgary, AB, Canada, ¹¹Nephrology, University of Montreal, Montreal, QC, Canada, ¹²Nephrology, University of Manitoba, Winnipeg, MB, Canada, ¹³University of Alberta, Alberta, AB, Canada, ¹⁴Ottawa Hospital Research Institute, Ottawa, ON, Canada, ¹⁵University of Toronto, Toronto, ON, Canada, ¹⁶Laval University, Que´bec, QC, Canada, ¹⁷Queen's University, Kingston, ON, Canada, ¹⁸Ottawa Health Research Institute, Ottawa, ON, Canada
*Purpose: This prospective study determined the association of immunosuppressant medication use with the outcomes of death, hospitalized infection, rejection of the failed allograft, and panel…
2022 American Transplant Congress
Effect of Covid-19 Vaccination on Markers of Rejection in Heart Transplant Recipients
Z. Pieters¹, E. Bruno¹, S. Kim¹, S. De Sirkar¹, M. Thomas¹, S. B. Sharmin², M. Liebo¹, A. Heroux¹, N. Clark¹, G. Reid¹, S. Uprichard², M. Yu¹
¹Medicine, Loyola University Medical Center, Maywood, IL, ²Loyola University Chicago, Chicago, IL
*Purpose: Heart transplant recipients have worse survival with COVID-19 than the general population, highlighting the importance of vaccination in these patients. The impact of vaccination…
2022 American Transplant Congress
Complete and High-Resolution HLA Typing Improves the Accuracy of Post-Transplant Assessment of De Novo Anti-Donor Immune-Mediated Events
M. Meneghini¹, A. Perona², E. Crespo³, F. J. Bemelman⁴, P. M. Reinke⁵, O. Viklicky⁶, M. Giral⁷, O. Bestard¹
¹Vall d'Hebron University Hospital, Barcelona, Spain, ²Universitat de Barcelona, Barcelona, Spain, ³Nephrology and Transplantation Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, ⁴Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁵Charité Universitätsmedizin, Berlin, Germany, ⁶Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, ⁷Nantes Université, Inserm, CHU Nantes, Nantes, France
*Purpose: High-resolution (HR) HLA typing using NGS technology has shown to improve the accuracy of assessing donor-recipient compatibility and characterization of pre-transplant anti HLA antibodies…
2022 American Transplant Congress
Is Pathologic AMR Grading Scale Associated with the Presence of Donor-Specific Antibodies?
S. Kim, J. Patel, M. Kittleson, T. Singer-Englar, N. Patel, D. Chang, E. Kransdorf, D. Emerson, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) has been defined by an expert pathology group in 2011 which resulted in the ISHLT pathologic AMR (pAMR) grading scale. The…