2015 American Transplant Congress
Activation of Th17 and Chronic Renal Allograft Rejection in Nonhuman Primates
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: We have previously reported successful induction of renal allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Although donor specific Th1 and…2015 American Transplant Congress
Prognostic Relevance of Rejection Episodes Detected Within the First 3 Weeks After Kidney Transplantation
Background:The relevance of cellular rejection events detected in the early phase after kidney transplantation for graft survival and function remains to be elucidated. Especially the…2015 American Transplant Congress
A Cross-Organ Tissue Gene Expression Immune Signature Predates Chronicity
Transplantation Surgery, UC San Francisco, San Francisco, CA.
Purpose Meta-analysis of 796 microarrays led to the discovery of 11 over-expressed genes (BASP1, CD6, CXCL9, CXCL10, INPP5D, ISG20, LCK, NKG7, PSMB9, RUNX3, and TAP1)…2015 American Transplant Congress
Activated T Regulatory Cells Escape Death by Increasing Cytoplasmic Serine Protease Inhibitor 6 (SPI6)
Renal/ Transplantation Research Center, Brigham and Women's Hospital, Boston, MA.
Regulatory T cells (Tregs) can employ a granzyme B (GrB)-dependent mechanism to mediate suppression of effector cells by inducing their apoptosis. In this study we…
American Transplant Congress abstracts