2015 American Transplant Congress
Evaluation of a Three-Dose Basiliximab Induction Immunosuppression Regimen in Adult Heart Transplant Recipients
University of Virginia Health System, Charlottesville, VA.
Background: Calcineurin inhibitors (CNI) are essential agents in most orthotopic heart transplantation (OHT) anti-rejection regimens. However, nephrotoxicity limits their use in the immediate post-OHT period,…2015 American Transplant Congress
Activated T Regulatory Cells Escape Death by Increasing Cytoplasmic Serine Protease Inhibitor 6 (SPI6)
Renal/ Transplantation Research Center, Brigham and Women's Hospital, Boston, MA.
Regulatory T cells (Tregs) can employ a granzyme B (GrB)-dependent mechanism to mediate suppression of effector cells by inducing their apoptosis. In this study we…2015 American Transplant Congress
Short- and Long-Term Outcomes of Mycophenolate Versus Azathioprine in a Large Cohort of Renal Transplant Recipients
1Barnes-Jewish Hospital, St. Louis; 2Washington University School of Medicine, St. Louis.
Purpose: Early studies comparing mycophenolate mofetil (MMF) to azathioprine (AZA) post-renal transplantation demonstrated superiority of MMF over AZA for the prevention of acute rejection (AR).…2015 American Transplant Congress
The Impact of Acute Rejection on Liver Transplant Survival in the New Millennium
Background: Based on pre-2000 data, acute rejection (AR) has long been considered clinically less significant in liver transplant (LT) vs. other organ recipients (Charlton et…2015 American Transplant Congress
CXCR4-SDF1α Blockade Reduces the Severity of Murine Heart Allograft Rejection
Introduction: The interaction of the CXCR4/SDF1α axis plays a critical role in the retention of hematopoietic stem cells in bone marrow. We hypothesized that the…2015 American Transplant Congress
Transplant Glomerulitis in Allograft Kidneys Is Correlated With Antibody-Mediated Rejection
Background: Antibody-mediated rejection manifests with glomerular and peritubular capillary inflammation, transplant glomerulopathy. Transplant glomerulitis is an increasingly recognized lesion in renal transplant biopsies, characterized by…2015 American Transplant Congress
DSA Detected by ELISA-PRA Is Associated With High Risk for Development of AMR in Stable Kidney Transplant Recipients
Background: Donor specific anti-HLA antibodies (DSA) are a major cause of antibody mediated rejection (AMR) and allograft loss, determining how to monitor patients for DSA…2015 American Transplant Congress
The Impact of Baseline and Follow-Up Social Adaptability Index Scores on Outcomes in Kidney Transplantation
Globally, socioeconomic status (SES) is a significant determinant of health outcomes, with the social adaptability index (SAI) representing a quantifiable and validated surrogate of SES.…2015 American Transplant Congress
Renal Allografts Demonstrate Improved Pathology After Belatacept Therapy
1University of Maryland School of Medicine, Baltimore; 2Johns Hopkins University, Baltimore.
Belatacept provides immunosuppression via costimulation blockade and has been associated with improved renal function compared to calcineurin inhibitor based therapies. We developed the Maryland Aggregate…2015 American Transplant Congress
Urinary Cell-Free DNA Is a Sensitive Marker of Early Renal Transplant Injury
Surgery, UC San Francisco, San Francisco, CA.
Introduction:Circulating donor-derived cell-free DNA (dd-cfDNA) has been reported as a surrogate of transplant injury in the blood but requires expensive donor and recipient DNA sequencing.Method:…
American Transplant Congress abstracts