ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Is There a Protective Value for Low Level Donor Specific Antibodies to Prevent Cardiac Allograft Vasculopathy After Heart Transplant?

    M. Kittleson, J. Patel, F. Liou, S. Siddiqui, J. Yabuno, D. Chang, D. Ramzy, L. Czer, F. Esmailian, N. Reinsmoen, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: Donor specific antibodies (DSA) following heart transplant has been reported to be associated with increased development of cardiac allograft vasculopathy (CAV) and risk of…
  • 2015 American Transplant Congress

    Impact of Donor Specific Antibodies in the Older Kidney Transplant Recipient

    S. Patel, J. Loucks-DeVos, R. Knight, S. Kuten, L. Gaber, A. Gaber.

    Houston Methodist Hospital, Houston.

    Recent evidence suggests that renal transplant recipients (RTR) with both rejection and donor specific antibodies (DSA) are at high risk of graft loss. Concurrently, the…
  • 2015 American Transplant Congress

    Non-Invasive Diagnosis of Post Kidney Transplant Complications by Urinary Exosomal mRNA Analysis

    H. Harada,1 T. Murakami,2 C. Yamamoto,2 M. Mitsuhashi.2

    1Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan; 2Hitachi Chemical Research Center, Inc., Irvine, CA.

    IntroductionMonitoring of kidney allograft status is important for the graft longevity. Conventional urinary markers are not sensitive and specific enough to diagnose graft injuries so…
  • 2015 American Transplant Congress

    Immunological Characterization of Full Facial Transplant Recipients

    T. Borges,1 J. Azzi,1 S. Tullius,1 A. Chandraker,1 B. Pomahac,2 N. Najafian,1 L. Riella.1

    1Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Plastic Surgery, Boston.

    Background: Despite the skin being considered the most immunogenic of all human tissues, full facial transplantation (FFT) has become a life transforming procedure with encouraging…
  • 2015 American Transplant Congress

    MicroRNA (miR) 144 Dysregulates TGFβ Signaling Cascade and Contributes to Development of BOS Following Human Lung Transplantation

    Z. Xu,1 S. Ramachandran,1 D. Nayak,1 M. Gunasekaran,1 E. Trulock,1 R. Hachem,1 D. Kreisel,1 T. Mohanakumar.1

    1Surgery, Washington Univ Sch Med, St. Louis, MO; 2Medicine, Washington Univ Sch Med, St. Louis, MO.

    Background: Bronchiolitis Obliterans Syndrome (BOS) is characterized by a fibroproliferative cascade that is not amenable to current treatment regimens and remains the major impediment for…
  • 2015 American Transplant Congress

    Chronic Active Antibody Mediated Rejection (cABMR): Treatment, Outcomes and Predictors of Graft Loss in a Large Case Series

    R. Redfield,1 T. Ellis,1 W. Zhong,1 T. Zens,1 M. Rizzari,1 J. Scalea,1 L. Jacobson,1 D. Mandelbrot,1 S. Parajuli,1 B. Muth,1 M. Mohamed,1 S. Panzer,1 B. Astor,1 M. Samaniego,2 D. Kaufman,1 A. Djamali.1

    1University of Wisconsin, Madison, WI; 2University of Michigan, Ann Arbor, MI.

    Background: CABMR is a barrier to long-term kidney allograft survival. There is little information on the treatment and outcomes of kidney transplant recipients with cABMR.Methods:…
  • 2015 American Transplant Congress

    Outcomes of Treatment of Late Antibody-Mediated Rejection in Primary Renal Transplant Recipients – A Single Center Experience

    R. Prashar, A. Patel, K. Venkat.

    Division of Nephrology and Transplant Institute, Henry Ford Hospital, Detroit, MI.

    Background: Successful reversal of early post-transplant antibody mediated rejection (AMR) is well documented, but data on the results of treatment of late AMR are lacking.…
  • 2015 American Transplant Congress

    Clinical Utility of Allospecific CD154+T-Cells in Children With Liver Or Intestine Transplantation (LTx, ITx)

    K. Soltys, G. Bond, G. Mazariegos, C. Ashokkumar, K. Dirling, L. O'Toole, P. Kachmar, T. Hartle, D. Martin, C. Trautz, R. Sindhi.

    Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    Background: Allospecific CD154+T-cytotoxic memory (CD154+TcM) have completed investigational evaluation as predictors of acute cellular rejection in children with LTx or ITx.Purpose: To evaluate CD154+TcM** as…
  • 2015 American Transplant Congress

    Responsiveness to Rituximab, Plasmapheresis and Intravenous Immunoglobulins in Antibody Mediated Rejections After Kidney and Pancreas – Kidney Transplantation

    E. Minué,1 L. León,1 P. Uva,1 A. Dotta,1 J. Walther,1 O. Casanova,1 F. Togniolo,1 O. Guardia,1 M. Rial,1 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; 2CEFYBO, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina.

    The antibody-mediated rejection (AMR) has become clinically critical because this form of rejection is usually unresponsive to conventional anti-rejection therapy. Therefore, it has been recognized…
  • 2015 American Transplant Congress

    HLA-C, KIR Genotypes and KIR Genotype/HLA –C Ligand Combination in Prediction of Early Acute Rejection After Liver Transplantation

    K. Park,1 J. Ryu,1 H. Park,3 Y. Kim,2 E.-J. Oh.2

    1Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea; 2Laboratory Medicine, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Republic of Korea; 3Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

    Introduction; Interaction of killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen class-I (HLA-I) regulates NK cytotoxicity and function. NK regulation influences on NK/T cell alloreactivity…
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