ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Early Vs. Late Acute Antibody Mediated Rejection Among Renal Transplant Recipients in Terms of Its Response to Rituximab Therapy-Single Center Expereince

    N. Nampoory, T. Alotaibi, O. Gheith, M. Halim, T. Mahmoud, P. Nair, M. Abdulmoneim, S. Alwaheb, R. Hasan.

    Nephrology, OTC of Kuwait, kuwait, Kuwait.

    IntroductionThere are no comparable trials concerning the use of rituximab among renal transplant recipients with acute antibody mediated rejection.Aim of the study:We aimed to compare…
  • 2015 American Transplant Congress

    Marrow Mesenchymal Stem Cells Attenuate Immune Rejection in Murine Lung Allograft

    X. Zhang,1 Y. Gong,2 K. Jiang,2 C. Wang,2 T. Xia,2 J. Li,2 J. Wang,2 J. Nie.2

    1Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China; 2Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.

    Objectives:The inherent immunosuppressive properties and low immunogenicity of mesenchymal stems cells (MSCs) suggested their therapeutic potential in transplantation. In this study we investigated if systematic…
  • 2015 American Transplant Congress

    The Association Between Donor & Recipient Gene Variants and Tacrolimus Safety & Efficacy in a Diverse Cohort of Kidney Transplant Recipients

    D. Taber, T. Srinivas, N. Pilch, M. Gebregziabher, L. Egede, P. Baliga, K. Chavin.

    Medical University of South Carolina, Charleston, SC.

    Previous studies have associated donor P-glycoprotein (PGP) gene variants (ABCB1) with risk of developing CNI-toxicity, while also establishing recipient CYP3A5*1 and ABCB1 gene variants are…
  • 2015 American Transplant Congress

    Inadequate Overall Immunosuppression Is a Risk for Late Acute Rejection Despite Alemtuzumab Induction in Simultaneous Pancreas Kidney Transplant Recipients

    J. Bank,1 M. Mallat,1 P. van der Boog,1 D. Braat,2 J. Ringers,2 M. Vergunst,3 S. Heidt,3 F. Claas,3 M. Reinders,1 J. de Fijter.1

    1Nephrology, LUMC, Leiden, Netherlands; 2Surgery, LUMC, Leiden, Netherlands; 3IHB, LUMC, Leiden, Netherlands.

    Introduction: Simultaneous pancreas-kidney transplantation (SPK) has become the treatment of choice for patients with end-stage renal disease due to Type 1 Diabetes Mellitus. SPK is…
  • 2015 American Transplant Congress

    Characterization of Natural T Effector Memory Cells Specific for Collagen type V, k-α-1-Tubulin and Vimentin

    J. Sullivan,1 D. Wilkes,2 T. Mohanakumar,3 W. Burlingham.1

    1Surgery, University of Wisconsin, Madison, WI; 2Medicine, Indiana University, Indianapolis, IN; 3Surgery, Washington University, St. Louis, MO.

    Background: Injury and repair processes are highly controlled, common occurrences of healthy tissue remodeling. During this process, cellular antigens that are not normally exposed to…
  • 2015 American Transplant Congress

    Evaluation of Serum sCD30 as a Predictor in Kidney Transplant Recipients

    X.-Z. Wang, W.-J. Xue, X.-H. Tian, J. Zheng, P.-X. Tian, X.-M. Ding.

    Kidney Transplantation, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

    Objective To explore the significance of serum CD30 in predicting acute rejection and pneumonia in kidney transplant recipients. Methods A total of 106 kidney transplant…
  • 2015 American Transplant Congress

    Evaluation of a Three-Dose Basiliximab Induction Immunosuppression Regimen in Adult Heart Transplant Recipients

    L. Donohue, W. Ally, S. Dunn, J. Kennedy, J. Bergin.

    University of Virginia Health System, Charlottesville, VA.

    Background: Calcineurin inhibitors (CNI) are essential agents in most orthotopic heart transplantation (OHT) anti-rejection regimens. However, nephrotoxicity limits their use in the immediate post-OHT period,…
  • 2015 American Transplant Congress

    A New Diagnostic Tool for Antibody Mediated Rejection in Heart and Lung Transplantation: Intragraft Donor Specific Anti-HLA Antibodies Detection

    J. Olagne,1,2,3 A. Parissiadis,2 N. Froelich,2 S. Caillard,1 M.-P. Chenard,3 E. Epailly,4 H. Kremer,4 T. Degot,5 S. Hirschi,5 R. Kessler,5 B. Moulin.1

    1Service de Néphrologie - Transplantation, Centre Hospitalier Universitaire, Strasbourg, France; 2Laboratoire d'Histocompatibilité, Etablissement Français du Sang, Strasbourg, Alsace, France; 3Département de Pathologie, Centre Hospitalier Universitaire, Strasbourg, France; 4Service de Cardiologie, Centre Hospitalier Universitaire, Strasbourg, France; 5Service de Pneumologie, Centre Hospitalier Universitaire, Strasbourg, France.

    INTRODUCTION: Antibody mediated rejection (AMR) is one of the causes of dysfunction and graft loss. The limited histological features, with a weak sensibility of c4d,…
  • 2015 American Transplant Congress

    The Impact of a Desensitization Protocol Using Plasmapheresis and Intravenous Immunoglobulin On Graft Outcome in Kidney Recipients With Donor Specific Anti-HLA Antibodies

    J. Junqueira, T. Leite, A. Junqueira, R. Esmeraldo.

    Hospital Geral de Fortaleza, Fortaleza, Brazil.

    Introduction: Kidney transplantation in patients with donor-specific anti-HLA antibodies (DSA) has been associated with a worse prognosis. The high cost, infectious complications and conflicting results…
  • 2015 American Transplant Congress

    Pre-Transplant Donor Specific Antibody With Negative Flow-Crossmatch Was Related to Higher Acute Rejection But Not to Poor Graft Survival

    A. Guichard-Romero, L. Marino-Vazquez, M. Lopez, N. Castelan, A. De-Santiago, N. Uribe-Uribe, J. Alberu, L. Morales-Buenrostro.

    Nephrology, Transplantation, and Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

    Background: DSA have been associated to lower graft survival and a higher humoral rejection rate, but there is a concern about the clinical impact of…
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