ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Pre-Transplant Donor Specific Antibody With Negative Flow-Crossmatch Was Related to Higher Acute Rejection But Not to Poor Graft Survival

    A. Guichard-Romero, L. Marino-Vazquez, M. Lopez, N. Castelan, A. De-Santiago, N. Uribe-Uribe, J. Alberu, L. Morales-Buenrostro.

    Nephrology, Transplantation, and Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

    Background: DSA have been associated to lower graft survival and a higher humoral rejection rate, but there is a concern about the clinical impact of…
  • 2015 American Transplant Congress

    High-Resolution Perfusion Mapping to Detect Heart Transplant Rejection Using Contrast Enhance Ultrasound

    K. Fischer,1,2 S. Ohori,2 F. Meral,1 S. Giannini,2 K. Hoffmeister,2 H. Athar,2 T. Ichimura,2 R. Smith,3 M. Giverts,2 F. Jolesz,1 R. Abdi.2

    1Radiology, Brigham and Women's Hospital, Boston; 2Medicine, Brigham and Women's Hospital, Boston; 3Pathology, Massachusetts General Hospital, Boston.

    Background: One of the key unmet needs in heart transplantation is an effective and accurate, non-invasive tool to diagnose acute and chronic heart transplant rejection.…
  • 2015 American Transplant Congress

    Improving ABMR Diagnostics Through Advanced Anti-HLA Antibody Screening Techniques

    R. Ponsirenas,1,2 H. Cazarote,1,2 S. Shimakura,3 J. Valdameri,1 F. Contieri,4 C. von Glehn,1,2 M. Susin.1,2

    1Transplant Immunology Laboratory, Pontifícia Universidade Católica do Paraná, Curitiba, Parana, Brazil; 2Medicine School, Pontifícia Universidade Católica do Paraná, Curitiba, Parana, Brazil; 3Departament of Statistics, Universidade Federal do Parana, Curitiba, Parana, Brazil; 4Kidney Transplant Unit, Hospital Evangélico de Curitiba, Curitiba, Parana, Brazil.

    The identification of low-level antibodies by single antigen bead methodology has brought advancements in risk evaluation of kidney transplants recipients. However, the use of the…
  • 2015 American Transplant Congress

    Cyclophosphamide as a Salvage Therapy for Combined Intravenous Immunoglobulins and Plasmapheresis Refractory Antibody-Mediated Rejection

    W. Habhab,1 A. Dada,2 M. Alwassia,1 N. Baz,2 N. Zabani,1 A. Fahmy,1 A. Abdul Malik.1

    1Nephrology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; 2Pathlogy, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

    Acute antibody-mediated rejection (AMR) poses a significant risk to graft survival. Current or standard treatment (ST) of AMR currently consists of plasmapheresis (PP), intravenous immunoglobulin…
  • 2015 American Transplant Congress

    Early Vs. Late Acute Antibody Mediated Rejection Among Renal Transplant Recipients in Terms of Its Response to Rituximab Therapy-Single Center Expereince

    N. Nampoory, T. Alotaibi, O. Gheith, M. Halim, T. Mahmoud, P. Nair, M. Abdulmoneim, S. Alwaheb, R. Hasan.

    Nephrology, OTC of Kuwait, kuwait, Kuwait.

    IntroductionThere are no comparable trials concerning the use of rituximab among renal transplant recipients with acute antibody mediated rejection.Aim of the study:We aimed to compare…
  • 2015 American Transplant Congress

    Marrow Mesenchymal Stem Cells Attenuate Immune Rejection in Murine Lung Allograft

    X. Zhang,1 Y. Gong,2 K. Jiang,2 C. Wang,2 T. Xia,2 J. Li,2 J. Wang,2 J. Nie.2

    1Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China; 2Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.

    Objectives:The inherent immunosuppressive properties and low immunogenicity of mesenchymal stems cells (MSCs) suggested their therapeutic potential in transplantation. In this study we investigated if systematic…
  • 2015 American Transplant Congress

    The Association Between Donor & Recipient Gene Variants and Tacrolimus Safety & Efficacy in a Diverse Cohort of Kidney Transplant Recipients

    D. Taber, T. Srinivas, N. Pilch, M. Gebregziabher, L. Egede, P. Baliga, K. Chavin.

    Medical University of South Carolina, Charleston, SC.

    Previous studies have associated donor P-glycoprotein (PGP) gene variants (ABCB1) with risk of developing CNI-toxicity, while also establishing recipient CYP3A5*1 and ABCB1 gene variants are…
  • 2015 American Transplant Congress

    Inadequate Overall Immunosuppression Is a Risk for Late Acute Rejection Despite Alemtuzumab Induction in Simultaneous Pancreas Kidney Transplant Recipients

    J. Bank,1 M. Mallat,1 P. van der Boog,1 D. Braat,2 J. Ringers,2 M. Vergunst,3 S. Heidt,3 F. Claas,3 M. Reinders,1 J. de Fijter.1

    1Nephrology, LUMC, Leiden, Netherlands; 2Surgery, LUMC, Leiden, Netherlands; 3IHB, LUMC, Leiden, Netherlands.

    Introduction: Simultaneous pancreas-kidney transplantation (SPK) has become the treatment of choice for patients with end-stage renal disease due to Type 1 Diabetes Mellitus. SPK is…
  • 2015 American Transplant Congress

    Characterization of Natural T Effector Memory Cells Specific for Collagen type V, k-α-1-Tubulin and Vimentin

    J. Sullivan,1 D. Wilkes,2 T. Mohanakumar,3 W. Burlingham.1

    1Surgery, University of Wisconsin, Madison, WI; 2Medicine, Indiana University, Indianapolis, IN; 3Surgery, Washington University, St. Louis, MO.

    Background: Injury and repair processes are highly controlled, common occurrences of healthy tissue remodeling. During this process, cellular antigens that are not normally exposed to…
  • 2015 American Transplant Congress

    Evaluation of Serum sCD30 as a Predictor in Kidney Transplant Recipients

    X.-Z. Wang, W.-J. Xue, X.-H. Tian, J. Zheng, P.-X. Tian, X.-M. Ding.

    Kidney Transplantation, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

    Objective To explore the significance of serum CD30 in predicting acute rejection and pneumonia in kidney transplant recipients. Methods A total of 106 kidney transplant…
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