2015 American Transplant Congress
Clinical Outcome of Patients With De Novo C1q Binding Donor-Specific HLA Antibodies After Renal Transplantation
A. Not all de novo donor-specific HLA antibodies (dnDSA) are causing immediate graft loss. The importance of complement-binding DSA was recently shown with a commercial…2015 American Transplant Congress
Structural and Functional Basis for Non-HLA Antibody Mediated AT1R Activation
Nephrology and Intensive Care Medicine, Charité University Hospital, Berlin, Germany.
Angiotensin II type receptor (AT1R), a heptahelical protein signals stimuli upon binding of natural peptide ligand angiotensin II (Ang II) and the pathogenic non-HLA IgG…2015 American Transplant Congress
Infectious Complications With Plasmapheresis in Combination With Antithymocyte Globulin Compared to Antithymocyte Globulin Alone in the Treatment of Acute Rejection
The Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, OH.
Background: Due to the complex nature of acute rejection (AR), multiple therapeutic modalities are necessary to prevent graft loss. The combination of prolonged cell depletion…2015 American Transplant Congress
The Potential Use of the Plasma Biomarker CXCL9 (MIG), Interleukin 2 Receptor alpha (IL2Rα) and SCGF-b as Predictors of Renal Graft Rejection
Background: Early detection of rejection in kidney transplantation is crucial, and predictive plasma biomarkers are highly desirable as non-invasive tests.Methods: From a cohort of 120…2015 American Transplant Congress
Intra-Lymphocyte Concentrations of Mycophenolic Acid Correlate With the Incidence of Early Graft Rejection in Renal Transplant Recipients
Introduction: Although routine therapeutic drug monitoring of mycophenolic acid (MPA) concentrations in plasma has been recommended to individualize MPA doses in transplant recipients, little is…2015 American Transplant Congress
Is There a Protective Value for Low Level Donor Specific Antibodies to Prevent Cardiac Allograft Vasculopathy After Heart Transplant?
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Donor specific antibodies (DSA) following heart transplant has been reported to be associated with increased development of cardiac allograft vasculopathy (CAV) and risk of…2015 American Transplant Congress
Multicenter Validation of a Molecular Diagnostic for Antibody-Mediated Rejection in Formalin-Fixed Paraffin-Embedded Human Renal Allograft Biopsies
1University of Alberta, Edmonton, Canada; 2Imperial College, London, United Kingdom.
Background: In 2013, the Banff classification adopted molecular diagnostics as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. The NanoString gene…2015 American Transplant Congress
Urinary CXCL10 Independently Improves the Noninvasive Diagnosis of Antibody-Mediated Kidney Allograft Rejection
The urinary levels of CXCL9 and CXCL10 can noninvasively diagnose T cell-mediated rejection (TCMR) of renal allografts. Their performance as diagnostic/prognostic markers of antibody-mediated rejection…2015 American Transplant Congress
Absence of Allograft TLR4 Receptor Signaling Attenuates Early Inflammation and Promotes Survival of Allografts Subjected to Prolonged Cold Ischemic Storage
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…2015 American Transplant Congress
Th17-Mediated Alloimmune Responses Play a Key Role in Intestinal Allograft Rejection in Humans
The Georgetown Transplant Institute, Washington, DC.
The majority of transplanted intestines still falls victim to allograft enteropathy, the underlying mechanisms of which are poorly understood. The purpose of this study was…
American Transplant Congress abstracts