ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Treatment of Hypertrophic Osteoarthropathy in an Intestinal Transplant Patient After Acute Cellular Rejection

    M. Keck.

    Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE.

    Background:Hypertrophic osteoarthropathy involves abnormal proliferation of bone at distal extremities. It involves clubbing, periostitis of tubular bones and synovial effusions. Some causes of secondary hypertrophic…
  • 2015 American Transplant Congress

    Non-Inferiority of Graft Survival of Living Unrelated Kidney Transplant compared to Living Related Kidney Transplant as Analyzed by First Degree Relative

    A. Patel, M. Goggins, D. Kim, P. Rohini, L. Malinzak.

    Henry Ford Transplant Institute, Detroit, MI.

    The perceived advantage of donating a kidney directly to a family member is difficult to uncouple in the setting of voluntary exchange or other kidney…
  • 2015 American Transplant Congress

    Transplant Glomerulopathy in a Novel Model of Chronic Antibody Mediated Rejection Is Associated With DSA and Glomerular IgM

    S. Panzer,1 S. Reese,1 N. Wilson Schlei,1 W. Zhong,2 A. Djamali.1

    1Medicine, University of Wisconsin Madison, Madison, WI; 2Pathology, University of Wisconsin Madison, Madison, WI.

    PurposeChronic active antibody mediated rejection (cAMR) and transplant glomerulopathy (TG) are major determinants of long-term allograft survival. However, the contribution of DSA and glomerular immunoglobulins…
  • 2015 American Transplant Congress

    Does Switching Predict Conversion: IgM De Novo Donor Specific HLA Antibodies Class Switch to IgG in Subclinical Antibody Mediated Rejection in Heart Transplant Recipients

    M. Askar,1 R. Rodriguez,1 L. Klingman,1 D. Thomas,1 A. Zhang,1 H. Morf,2 N. Hamon,1 N. Moazami,1 E. Hsich,1 D. Taylor,1 R. Starling,1 C. Tan.1

    1Cleveland Clinic, Cleveland; 2School of Medicine, Leipzig University, Leipzig, Germany.

    Background: Concomitant C4d and C3d detection in heart biopsies correlates with circulating DSA and graft dysfunction. Detection of C4d only in surveillance biopsies is not…
  • 2015 American Transplant Congress

    An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation

    C. Falk,1 I. Goldschmidt,2 F. Mutschler,2 C. Neudörfl,1 J. Keil,1 K. Daemen,1 F. Lehner,3 R. Mikolajzcyk,4 A. Karch,4 U. Baumann.2

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Division of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany; 3Department of Visceral General and Transplant Surgery, Hannover Medical School, Hannover, Germany; 4Department of Epidemiology, Helmholtz Center for Infection Research, HZI, Braunschweig, Braunschweig, Germany.

    The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…
  • 2015 American Transplant Congress

    The Clinical Outcome of Plasma Cell-Rich Rejection of Kidney Allograft

    J. Hasegawa,1 K. Honda,2 S. Wakai,1 H. Shirakawa,3 M. Okumi,3 K. Omoto,3 H. Ishida,3 K. Tanabe.3

    1Nephrology, Ohkubo Hospital, Tokyo, Japan; 2Pathology, Tokyo Women's Medical University, Tokyo, Japan; 3Urology, Tokyo Women's Medical University, Tokyo, Japan.

    Background: Plasma cell-rich rejection (PCRR) is a rare type of allograft rejection characterized by the presence of mature plasma cells. This type of rejection has…
  • 2015 American Transplant Congress

    Renal Outcomes of Cross Match Positive Simultaneous Liver Kidney (SLK) Transplant Recipients Compared to Cross Match Positive Kidney Allograft Recipients

    S. Vaishnav,1 T. Taber,1 W. Goggins,2 S. Nagaraju,2 J. Fridell,2 A. Sharfuddin,1 M. Yaqub,1 D. Mishler,1 M. Mujtaba.1

    1IUSM, IU Health, Indianapolis, IN; 2Surgery, Transplant, Indiana University School of Medicine, Indianapolis, IN.

    The protective role of liver in cross-match(XM) positive SLK recipients and its impact on the incidence of renal antibody mediated rejection (AMR) is unclear.A retrospective…
  • 2015 American Transplant Congress

    Pretransplant Antibodies Against Angiotensin II Type 1 Receptor in Renal Transplantation: Preliminary Data from the KNOW-KT Study

    K. Huh,1 J. Lee,1 Y. Park,2 Y. Kim,1 C. Ahn.3

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

    BackgroundThe antibodies (Abs) against angiotensin II type 1 receptor (AT1R) have been suggested as a risk factor for graft failure and acute rejection. However, incidence…
  • 2015 American Transplant Congress

    Thymoglobulin Versus IL2RA: Three Year Results of a Randomized Controlled Trial

    N. Pilch, H. Meadows, D. Taber, J. Fleming, C. Mardis, S. Nadig, J. McGillicuddy, T. Srinivas, C. Bratton, P. Baliga, K. Chavin.

    Transplant, MUSC, Charleston, SC.

    This is a three year follow-up of a prospective, randomized controlled trial (RCT) to determine the safety and efficacy of induction with rabbit antithymocyte globulin…
  • 2015 American Transplant Congress

    Constitutively Upregulated Expression of Complement and Matrix Transcripts in Kidney Transplant Recipients Who Develop Acute Rejection

    K. Keslar,1 J. Reid-Adam,4 E. Kwon,4 D. Hricik,5 E. Poggio,2,3 P. Heeger,4 R. Fairchild.1,3

    1Immunology, Cleveland Clinic; 2Nephrology, Cleveland Clinic; 3Glickman Urological Institute and Transplant Center, Cleveland Clinic, Cleveland, OH; 4Icahn School of Medicine, Mount Sinai, New York, NY; 5Nephrology, UH Case Medical Center, Cleveland, OH.

    Identification of kidney transplants at elevated risk of acute rejection (AR) and/or chronic injury prior to loss of kidney function (GFR) could guide therapies to…
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