ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Single Center Experience With the Use of an Abbreviated Anti-Thymocyte Globulin and Basiliximab Combination Protocol in Renal Transplantation

    V. Whittaker,1 D. Halleran,1 S. Narsipar,1 J. Melancon.2

    1Surgery, State University New York Upstate Medical University, Syracuse, NY; 2Surgery, George Washington University, Washington, DC.

    Purpose: To report one year outcomes from single center experience with a novel induction regimen using anti-thymocyte globulin ( ATG)(rabbit)rATG (3 mg/kg) in divided doses…
  • 2015 American Transplant Congress

    The Effect of Compatibility of ABO Blood Type Antigens on Graft Survival of Intestinal Transplants

    J. Cai,1 A. Qing,2 G. Wu,3 M. Everly,1 P. Terasaki.1

    1Terasaki Foundation Lab, Los Angeles; 2Lincoln High School, Stockton; 3The 4th Military Medical University, Xi-An, China.

    Due to the introduction of new immunosuppressive agents and development of pre- and post-transplant patient management, ABO blood group incompatibility is no longer considered an…
  • 2015 American Transplant Congress

    The Impact of Alemtuzumab and Basiliximab Induction On Patient and Graft Survival in Single Lung Transplant Recipients

    Y. Furuya,1 S. Jayarajan,2 S. Taghavi,2 V. Ambur,2 F. Cordova,3 N. Patel,3 Y. Toyoda.4

    1Internal Medicine, Temple University Hospital, Philadelphia, PA; 2Surgery, Temple University Hospital, Philadelphia, PA; 3Pulmonary & Critical Care, Temple University Hospital, Philadelphia, PA; 4Cardiothoracic Surgery, Temple University Hospital, Philadelphia, PA.

    PurposeTo evaluate the impact of alemtuzumab, basiliximab and no induction therapy on patient survival and chronic rejection.Methods3242 adult single lung transplantation from 2006 to 2013…
  • 2015 American Transplant Congress

    Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization

    C. Burghuber,1,2 J. Kwun,1,3 F. Leopardi,3 A. Gibby,1 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1,3

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Preformed and newly formed alloantibody post transplantation (TX) can significantly deteriorate graft survival. Patterns of humoral rejection in sensitized patients varies significantly due to…
  • 2015 American Transplant Congress

    Differentially Expressed IL-6Rα and GP130 Genes in Kidney Biopsies (Bxs) Suggests Different Roles of IL-6 Signaling in Antibody (ABMR)- and Cell (CMR)-Mediated Rejection

    H. Zhang,1 D. Thomas,1 J. Kowalewska,2 E. Suviolahti,1 H. Shafi,2 C. Nast,2 A. Gertych,2 A. Vo,1 M. Haas,2 S. Jordan,1 M. Toyoda.1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; 2Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: IL-6 exerts immunoregulatory properties through IL-6 receptors, IL-6Rα and gp130. Our previous studies suggested the involvement of antibody-dependent cellular cytotoxicity (ADCC) and its related…
  • 2015 American Transplant Congress

    Neogenin Functions as a Chemokinetic Receptor on Activated CD4+ T Lymphocytes

    L. Boneschansker,1 H. Nakayama,1 M. Eisenga,1 M. Klagsbrun,1 D. Irimia,2 D. Briscoe.1

    1Boston Children's Hospital, Boston; 2Massachusetts General Hospital, Boston.

    Increasing data indicates that axonal guidance cues play a critical role in immunity, both in activation, migration as well as in the process of inflammation…
  • 2015 American Transplant Congress

    A Prospective Study of Renal Function and Histological Changes in Renal Transplant Recipients With Acute Clinical and Subclinical Rejection

    S. Chen,1 R. Mehta,1 P. Sood,1 P. Randhawa,2 N. Shah,1 C. Wu,1 A. Tevar,3 S. Hariharan.1

    1Nephrology, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; 3Transplant Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

    Background: To study the impact on renal function and histological changes in patients(pts) with acute clinical rejection(ACR) and subclinical rejection(SCR) from 3 to 12 month(m)…
  • 2015 American Transplant Congress

    Left Ventricular Assist Device–Associated Allosensitization — Clinical Implications

    B.-S. Ko, C. Willis, S. Drakos, D. Hurst, A. Kfoury, G. Snow, J. Delgado, E. Hammond, C. Selzman, R. Alharethi, S. McKellar, J. Nativi-Nicolau, E. Gilbert, P. Revelo, D. Miller, B. Reid, J. Fang, D. Eckles, J. Stehlik.

    U.T.A.H. Cardiac Transplant Program, Salt Lake City, UT.

    Purpose: Allosensitization has been recognized as a prognostic marker of worse outcome after transplant. It is unclear, however, whether sensitization events that take place shortly…
  • 2015 American Transplant Congress

    Elevated ST2 Levels Are Associated With Increased Risk of Antibody Mediated Rejection in Heart Transplant Recipients

    A. Grupper,1 S. Kushwaha,1 O. Abou Ezzeddine,1 J. Geske,2 W. Kremers,2 B. Edwards,1 N. Pereira.1

    1Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN; 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.

    Objective: Serum ST2, a member of the interleukin (IL) 1 receptor family, is a novel biomarker that reflects cardiac remodeling and fibrosis and is associated…
  • 2015 American Transplant Congress

    Propensity Score-Weighted Analysis of Induction Therapies in Live Donor Kidney Transplantation in Modern Immunosuppression Era

    B. Tanriover,1 S. Zhang,2 M. MacConmara.3

    1Medicine, UTSW, Dallas, TX; 2Clinical Sciences, UTSW, Dallas, TX; 3Surgery, UTSW, Dallas, TX.

    Background: Induction therapy with interleukin-2 receptor antagonist (IL2-RA) is recommended as a first line agent in living donor renal transplantation (LRT). However, use of IL2-RA…
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