2015 American Transplant Congress
Histologic Findings in Pre-transplant AT1Rab + ve Patients Point to an Increase in Sub-Intimal Fibrosis During Acute Rejection and in 12 mo. Protocol Renal Graft Biopsies
Previous reports have described an increase in arteritis during acute rejection (AR) in angiotensin II type 1 receptor antibody (AT1Rab) positive (ve+) kidney transplant recipients…2015 American Transplant Congress
Preformed Anti-HLA DP Donor Specific Antibodies Are Clinically Significant in Renal Transplantation
Renal and Transplant Medicine, Imperial Healthcare NHS Trust, London, United Kingdom.
Background: Whilst preformed [PF] anti-HLA A, B, DR and DQ donor specific antibodies [DSAbs] are associated with poorer allograft outcomes secondary to antibody mediated injury,…2015 American Transplant Congress
Results of ABO Incompatible Liver Transplantation Using a Simplified Protocol at a Single Institution
BackgroundABO incompatible (ABOi) living donor liver transplantation (LDLT) has become a feasible option for patients with end-stage liver disease due to development of various desensitization…2015 American Transplant Congress
Everolimus With Low Dose Tacrolimus in Intestinal Transplantation
Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.
Introduction: Renal dysfunction is a well-known complication after organ transplant given immunosuppression (ISP) with calcineurin inhibitors. This is especially true after intestinal transplant (ITx) given…2015 American Transplant Congress
Bortezomib-Based Multi-Modality Protocol for Donor-Specific Antibody Treatment in Lung Transplant Recipients
Duke University Hospital, Durham, NC.
Background Donor specific antibodies (DSAs) after lung transplant have been implicated in the development of chronic lung allograft dysfunction and mortality. The ideal treatment strategy…2015 American Transplant Congress
A Critical Analysis of the Impact of Socioeconomic Status on Racial Disparities in Kidney Transplantation
Medical University of South Carolina, Charleston, SC.
Socioeconomic status (SES) is a significant determinant of health outcomes and may be an important component of racial disparities in kidney transplantation (KTX). While the…2015 American Transplant Congress
Molecular and Functional Immune Assays as Non-Invasive Diagnostic Tools to Assess the Risk of Acute Subclinical Rejection After Kidney Transplantation
Subclinical allograft rejection (sc-AR) is still a main cause of allograft loss that can only be assessed through invasive surveillance biopsies. We sought to investigate…2015 American Transplant Congress
Once Daily Dosing Is as Effective as Twice Daily Dosing of Immediate Release Tacrolimus
1Barnes-Jewish Hospital, St. Louis; 2Washington University School of Medicine, St. Louis.
Purpose: Extended release (ER) tacrolimus (tac) has been available as Advagraf® for many years and as Astagraf XL® in the US since 2013. Immediate release…2015 American Transplant Congress
Alemtuzumab Induction Is Protective Against Acute Rejection in Kidney Recipients With Subtherapeutic Tacrolimus Concentrations
Transplant Surgery, University of North Carolina Hospitals, Chapel Hill, NC.
Purpose: To determine the effect of attaining early therapeutic tacrolimus (TAC) trough concentrations on biopsy-proven acute rejection (BPAR) within 12 months post-transplantation in adult kidney…2015 American Transplant Congress
Toll-Like Receptor 4-Signaling Abrogates Inhibitory Effect of Calcineurin Inhibitor on B-Cells Responding to Blood Group A-Antigens
Transplant Unit, Hiroshima University, Hiroshima, Japan.
Aim: Bacterial infection following ABO-incompatible organ-transplantation is associated with refractory Ab-mediated rejection. Here, we investigated the influence of toll-like receptor (TLR)-signaling, via the binding of…
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