ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    The Effect of Rituximab Therapy on Regulatory B Cell and Prevention of Chronic Antibody Mediated Rejection in Kidney Transplantation Recipients

    M. Ikemiyagi, R. Ishii, S. Miyairi, T. Hirai, K. Omoto, K. Tanabe.

    Urology, Tokyo Women's Medical University, Tokyo, Japan.

    We previously reported that a single administration of low dose rituximab (RIT) before kidney transplant reduced the incidence rate of chronic antibody mediated rejection (CAMR)…
  • 2015 American Transplant Congress

    Kynurenine Assay to Detect Inflammation in Transplant Patient: Clinical Results

    D. Abendroth,1 J. Kaden,2 M. Marzinzig,1 M. Stangl.3

    1Center of Surgery, University of Ulm, Ulm, Germany; 2Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany; 3General, Visceral and Transplant Surgery, Ludwig-Maximilians-Universität, München, Munich, Germany.

    Introduction: Ideal biomarker should be specific, sensitive, non-invasive, mirror the benefit of therapy and offer prognostic potential. We developed a test using a colorimetric assay…
  • 2015 American Transplant Congress

    Pertubations in the Urinary Exosome in Transplant Rejection

    T. Sigdel,1 Y. Ng,1 S. Lee,2 C. Nicora,3 W.-J. Qian,3 D. Camp II,3 M. Sarwal.1

    1Surgery, UC San Francisco, San Francisco, CA; 2Nephrology, Kyung Hee University, Seoul, Korea; 3Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA.

    Urine exosomes are small vesicles shed into the urine by exocytosis from all renal epithelial cell types under normal physiologic states and disease states, and…
  • 2015 American Transplant Congress

    Repeat Donor HLA Mismatch Antigens and Kidney Transplant Outcome

    P. Lokhandwala,1 M. Wang,2 Z. Kadry,3 R. Shah,3 A. Jain,3 J. Gaspari,1 N. Ghahramani,4 C. Abendroth,1 H. Shike.1

    1Pathology, Penn State Hershey Medical Center, Hershey, PA; 2Public Health Sciences, Penn State College of Medicine, Hershey; 3Transplant Surgery, PSHMC, Hershey; 4Nephrology, PSHMC, Hershey.

    Background: Historically, poorer outcome has been reported in kidney re-transplant patients with repeat HLA mismatch antigens. Transplant practice has evolved. Risk of repeat mismatch antigen…
  • 2015 American Transplant Congress

    Efficacy and Safety of Induction Therapy With Monoclonal Versus Polyclonal Antibodies in Kidney Transplant Recipients in the Last Five Years (2008-2013) in Our Institution

    M. Fernández, M. López, M. Ferreira, A. Aguilar, C. Jiménez, R. Selgas.

    Nephrology, La Paz Hospital, Madrid, Spain.

    Induction immunosuppression in renal transplantation is not clearly defined. We analyze the efficacy and safety of the used regimens at our institution in the last…
  • 2015 American Transplant Congress

    Tacrolimus Trough Concentrations Increase in Intestinal Transplant Recipients During Episodes of Acute Cellular Rejection

    A. Lichvar,1 D. Deen,2 H. Johnson,1 J. Bonner,3 G. Bond,4 G. Costa,4 R. Cruz,4 K. Abu-Elmagd,5 R. Venkataramanan.6,7

    1Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Department of Pharmacy, Memorial University Medical Center, Savannah, GA; 3Northern Institute for Cancer Research at Newcastle University, Tyne and Wear, United Kingdom; 4Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; 5Center for Gut Rehabilitation and Transplantation, Cleveland Clinic, Cleveland, OH; 6Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA; 7Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Introduction: Acute cellular rejection (ACR) in small bowel transplant recipients is expected to increase intestinal permeability and to reduce intestinal CYP3A/p-glycoprotein activity. These changes may…
  • 2015 American Transplant Congress

    Husband to Wife Renal Transplants Are Associated With a Higher Risk of Early Antibody Mediated Rejection and Transplant Glomerulopathy

    H. Sawhney, M. Willicombe, P. Brookes, E. Santos, D. Taube.

    Renal and Transplant Centre, Hammersmith Hospital, Imperial Healthcare NHS Trust, London, England, United Kingdom.

    Patients with a low level preformed donor specific antibodies [DSA] with a negative FCXM/CDC cross match are at high risk of antibody mediated rejection [AMR]…
  • 2015 American Transplant Congress

    Clinical and Biochemical Results of BK Virus Nephropathy in Kidney Allograft Recipients

    B. Canbakan,1 I. Akdağ,1 ö. Merhametsiz,1 ö. Yayar,2 E. Oğuz,1 M. Kiliç,3 D. Ayli.1

    1Nephrology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey; 2Nephrology, Atatürk Training and Research Hospital, Ankara, Turkey; 3General Surgery, Atatürk Training and Research Hospital, Ankara, Turkey.

    BK virus (BKV) nephropathy has emerged as a significant cause of graft dysfuction in kidney allograft recipients after using powerful immunosupressive treatment protocols in recent…
  • 2015 American Transplant Congress

    Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model

    G. Furtmüller,1 N. Crane,2 R. Luthra,2 E. Swanson,1 H.-T. Cheng,1 B. Oh,1 M. Fryer,1 E. Elster,2 W. Lee,1 G. Brandacher.1

    1Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; 2Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD.

    Purpose: To evaluate imaging modalities such as 3CCD and infrared (IR) technology as a means of non-invasive monitoring of graft acceptance and rejection in the…
  • 2015 American Transplant Congress

    Interleukin-17 Deficiency Attenuates Renal Allograft Injury and Prolongs Survival in a Murine Transplantation Model

    T. Kwan,1,2 S. Chadban,1,2 J. Ma,1,2 S. Bao,2,3 S. Alexander,2,4 H. Wu.1,2

    1Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; 2Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; 3Discipline of Pathology, School of Medical Sciences, Sydney, New South Wales, Australia; 4Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

    Aim:To investigate the role of IL-17 in allograft rejection using a murine model of fully MHC-mismatched renal transplantation.Methods:Life-sustaining kidney transplants were performed in nephrectomized mice:…
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