ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2015 American Transplant Congress

    Current Status of US Intestinal and Multivisceral Transplantation: An Analysis of the UNOS Intestine Transplant Registry

    J. Cai,1 A. Qing,2 G. Wu,3 M. Everly,1 P. Terasaki.1

    1Terasaki Foundation Lab, Los Angeles, CA; 2Lincoln High School, Stockton, CA; 3The 4th Military Medical University, Xi-An, China.

    The purpose of this study is to analyze the current status of US intestinal transplantation (IT). As of 9/19/2014, 2441 IT have been performed in…
  • 2015 American Transplant Congress

    Lung Biopsy Findings in Pediatric Lung Transplant Patients With Restrictive Physiology

    J. Blatter,1 F. White,2 A. Faro,1 P. Michelson,1 U. Boston,3 P. Eghtesady,3 S. Sweet.1

    1Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO; 2Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO; 3Department of Cardiothoracic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO.

    Background: Long-term survival in pediatric lung transplantation is limited by bronchiolitis obliterans (BO), but varieties of chronic lung allograft dysfunction (CLAD) are poorly understood. Restrictive…
  • 2015 American Transplant Congress

    mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia

    I. Werner, A. Hernandez-Sierra, F. Guo, A. Moritz, A. Beiras-Fernandez.

    Department of Thoracic and Cardiovascular Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany.

    ObjectivemTOR inhibitors Everolimus and Sirolimus are currently used as maintenance immunosuppressive agents to prevent rejection of solid transplanted organs. Episodes of transplant rejection and graft…
  • 2015 American Transplant Congress

    Detection of Donor-Specific Anti-HLA Antibodies Is Associated With Changes in the Peripheral Distribution of NK Cell Subsets in Kidney Allograft Recipients

    M. Crespo,1 D. Redondo,1 J. Yelamos,2 A. Muntasell,2 M. Pérez-Sáez,1 M. Lopez-Montañes,3 C. Garcia,4 A. Torío,5 J. Hernandez,4 M. Mir,1 M. Lopez-Botet,3 J. Pascual.1

    1Nephrology, Hospital del Mar, Barcelona, Spain; 2Servicio de Inmunología, Institut Mar d'Investigacions Mediques, Barcelona, Spain; 3Grup de Investigacio en Immunologia, Universitat Pompeu Fabra, Barcelona, Spain; 4Laboratori de Referencia de Catalunya, Barcelona, Spain; 5Immunology Unit, Hospital de Alicante, Alicante, Spain.

    Background: Microvascular damage has become the real protagonist involved in antibody-mediated rejection and NK-cell antibody-dependent cell mediated cytotoxicity (ADCC) has been proposed as a contributing…
  • 2015 American Transplant Congress

    Calcineurin-Inhibitor Conversion to mTOR Inhibitor in Renal Transplant Recipients Leads to Worse Long Term Clinical Outcomes

    A. Alvarado,1 A. Shetty,1 O. Traitanon,1 J. Leventhal,1 V. Mas,2 D. Chhabra,3 J. Matthews,1 L. Gallon.1

    1Comprehensive Transplant Center, Northwestern University, Chicago, IL; 2University of Virgina, Charlottesville, Va; 3Advocate Christ Medical Center, Chicago, IL.

    We previously reported the short-term feasibility of Calcineurin-Inhibitor (CNI) elimination in kidney transplant recipients. We now report the long-term clinical impact on renal allograft function…
  • 2015 American Transplant Congress

    Reassessing Tubulitis and Interstitial Infiltrate: Creating a New Probabilistic Definition of TCMR

    P. Halloran, I. Salazar, M. Lopez, J. Chang.

    Alberta Transplant Applied Genomics Centre, Edmonton, Canada.

    Conventional diagnosis of T cell-mediated rejection (TCMR) in kidney transplant biopsies relies on interstitial inflammation (i-lesions), tubulitis (t-lesions), vasculitis (v-lesions) and experience-derived interpretation rules. The…
  • 2015 American Transplant Congress

    Antibody-Mediated Rejection of Renal Allografts by CCR5-/- Mice Does Not Require CD8 T Cells

    N. Kohei,1 T. Tanaka,1 H. Tsuda,1 N. Dvorina,1 K. Tanabe,2 W. Baldwin,1 R. Fairchild.1

    1Immunology, Cleveland Clinic, Cleveland, OH; 2Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.

    Antibody-mediated acute and chronic graft injury remains a major cause of renal allograft loss. Mechanisms underlying these injuries remain unclear due in part to the…
  • 2015 American Transplant Congress

    Serum Proteins Are Significantly Upregulated in Patients With Clinical Antibody-Mediated Rejection

    A. Gareau,1 I. Gibson,2 C. Wiebe,1 J. Ho,1 D. Rush,1 P. Nickerson.1

    1Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; 2Pathology, University of Manitoba, Winnipeg, MB, Canada.

    Background: Antibody-mediated rejection (ABMR) is a major pathway associated with late graft loss. Although serum de novo donor-specific HLA antibodies are frequently observed in ABMR,…
  • 2015 American Transplant Congress

    Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated With Belatacept

    W. Kitchens,1 A. Farris,2 S. Pastan,1 T. Pearson,1 C. Larsen,1 A. Adams.1

    1Emory Transplant Center, Atlanta, GA; 2Department of Pathology, Emory University Hospital, Atlanta, GA.

    Introduction: Focal segmental glomerulosclerosis (FSGS) is a cause of end-stage renal failure that frequently recurs following renal transplant, often leading to early allograft loss. A…
  • 2015 American Transplant Congress

    Characteristics and Consequences of Renal Allograft Rejections Due to Nonadherence

    S. Patel, S. Kuten, J. Everett, J. Loucks-DeVos, L. Gaber, A. Gaber, R. Knight.

    Houston Methodist Hospital, Houston.

    Non-adherence (NA) with immunosuppressive medications is associated with increased healthcare costs, rejection risk, and graft loss. NA is difficult to measure, however, and is often…
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