Articles tagged "Rejection"

2015 American Transplant Congress
The Role of Skin-Specific Immunobiology and Major Histocompatibility Complex Sharing in Vascularized Composite Allograft Tolerance
D. Leonard, K. Shanmugarajah, H. Powell, A. Albritton, C. Mallard, D. Sachs, C. Cetrulo, Jr., J. Kurtz.
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA.
Background: We have developed a reproducible model for induction of tolerance of all components of VCAs across haploidentical MHC barriers in miniature swine. The purpose…
2015 American Transplant Congress
DNA Methylation of the IFNγ Promoter in CD8+ T Cell Subsets Is Modulated by CMV Infection but not by Alloreactivity in Kidney Transplantation Patients
K. Boer,¹ E. de Wit,¹ L. Hofland,² M. Betjes,¹ C. Baan.¹
¹Internal Medicine - Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands; ²Internal Medicine - Endocrinology, Erasmus University Medical Center, Rotterdam, Netherlands.
Introduction DNA methylation plays a critical role in the function of cells, including cells of the immune system. Little is known about the methylation status…
2015 American Transplant Congress
The Value of Surveillance Testing for De Novo Donor Specific Antibodies Following Renal Transplantation
O. Pankewycz,¹ M. Laftavi,² M. Said,² K. Chapin,² L. Feng.²
¹Medicine, SUNY at Buffalo/ECMC, Buffalo, NY; ²Surgery, SUNY at Buffalo/ECMC, Buffalo, NY.
The development of de novo donor specific antibodies (dnDSA) usually leads to a reduction in renal graft survival. The deleterious influence of dnDSA is most…
2015 American Transplant Congress
Tacrolimus for the Treatment of Refractory Biopsy-Proven Acute Cellular Rejection in Patients on Belatacept-Based, CNI- and Steroid-Free Immunosuppression Regimens
K. Trobaugh,¹ A. Shields,^1,2 S. Tremblay,¹ R. Alloway,¹ M. Cardi,² D. Witte,¹ F. Paterno,¹ M. Cuffy,¹ E. Woodle.¹
¹Univ of Cincinnati, Cincinnati; ²The Christ Hospital, Cincinnati.
Background: Tacrolimus (TAC) is effective as rescue treatment (tx) in renal transplant patients (pts) on cyclosporine-based immunosuppression (IS) who have recurrent or resistant acute rejection…
2015 American Transplant Congress
HLA Broad Antigen and Eplet Mismatches in Determining the Risk of Acute Rejection After Kidney Transplantation
H. Do Nguyen,¹ W. Lim,^1,2 J. Chapman,³ J. Craig,^3,4 G. Wong.^3,4
¹School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; ²Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; ³Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; ⁴School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Aim: To determine the clinical relevance of HLA-ABDR broad antigen and eplet matching for predicting acute rejection after kidney transplantation.Background: HLAMatchmaker determines structurally HLA compatibility…
2015 American Transplant Congress
Is Electron Microscopy Adding a Diagnostic Advantage in the Evaluation of Renal Allograft Biopsies for Antibody Mediated Rejection (AMR)?
J. Papadimitriou, M. Chaudhry, C. Drachenberg, R. Ugarte, D. Klassen, E. Ramos, C. Cangro, B. Thomas, M. Mavanur, A. Haririan.
Pathology and Medicine, University of Maryland School of Medicine, Baltimore, MD.
Some electron microscopy (EM) findings have been consistently associated with antibody mediated microvascular injury; however, no large studies have been performed examining the concrete advantage…
2015 American Transplant Congress
CHBP Suppresses Acute Rejection by Inhibition Maturation of Dendritic Cells though Jak-2/STAT3/SOCS1 Signal in Rat Kidney Transplantation
C. Yang,¹ Y. Zhang,¹ J. Wang,¹ L. Li,¹ L. Wang,² M. Xu,¹ Y. Long,³ R. Rong,¹ T. Zhu.¹
¹Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ²Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China; ³CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Background. Renal acute rejection (AR) affects both allografts and recipients survival. We recently synthesized a novel proteolysis-resistant cyclic helix B peptide (CHBP), which exerts promising…
2015 American Transplant Congress
Role of Innate Immune Cells in Chronic Allograft Loss and Novel Strategies to Target Them
C. Wu,^1,2 P. Zhao,¹ W. Liu,¹ X. Xiao,¹ X. Shi,¹ Y. Peng,¹ M. Kloc,¹ X. He,² M. Ghobrial,¹ X. Li.¹
¹Center for Immunobiology and Transplantation Research, Houston Methodist Hospital and Houston Methodist Research Institute, Houston, TX; ²Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Despite remarkable improvements in short term transplant survival, the long-term outcome of allografts remains poor in the clinic, and most transplants are eventually lost due…
2015 American Transplant Congress
The Occurrence of v- Lesions Is Not Associated With Decreased Graft Survival
P. Halloran, I. Salazar, M. Lopez, J. Chang.
ATAGC, Edmonton, Canada.
Intimal arteritis (v-lesions) in kidney transplant biopsies has been believed to have major prognostic and diagnostic significance. We assessed the relationship of v-lesions to prognosis…
2015 American Transplant Congress
Glucose Chemical Exchange Saturation Transfer MRI of Acute Renal Allograft Rejection
D. Kentrup,¹ A. Busch,² H. Pawelski,¹ V. Hoerr,^2,3 S. Reuter.¹
¹Department of Medicine D, University Hospital Münster, Münster, Germany; ²Department of Clinical Radiology, University Hospital Münster, Münster, Germany; ³Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
Purpose: During acute rejection episodes large amounts of immune cells infiltrate renal grafts, leading to inflammation accompanied by an increased glucose metabolism.Given these circumstances we…