Articles tagged "Rejection"

2015 American Transplant Congress
Differentially Expressed IL-6Rα and GP130 Genes in Kidney Biopsies (Bxs) Suggests Different Roles of IL-6 Signaling in Antibody (ABMR)- and Cell (CMR)-Mediated Rejection
H. Zhang,¹ D. Thomas,¹ J. Kowalewska,² E. Suviolahti,¹ H. Shafi,² C. Nast,² A. Gertych,² A. Vo,¹ M. Haas,² S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: IL-6 exerts immunoregulatory properties through IL-6 receptors, IL-6Rα and gp130. Our previous studies suggested the involvement of antibody-dependent cellular cytotoxicity (ADCC) and its related…
2015 American Transplant Congress
Neogenin Functions as a Chemokinetic Receptor on Activated CD4+ T Lymphocytes
L. Boneschansker,¹ H. Nakayama,¹ M. Eisenga,¹ M. Klagsbrun,¹ D. Irimia,² D. Briscoe.¹
¹Boston Children's Hospital, Boston; ²Massachusetts General Hospital, Boston.
Increasing data indicates that axonal guidance cues play a critical role in immunity, both in activation, migration as well as in the process of inflammation…
2015 American Transplant Congress
A Prospective Study of Renal Function and Histological Changes in Renal Transplant Recipients With Acute Clinical and Subclinical Rejection
S. Chen,¹ R. Mehta,¹ P. Sood,¹ P. Randhawa,² N. Shah,¹ C. Wu,¹ A. Tevar,³ S. Hariharan.¹
¹Nephrology, University of Pittsburgh Medical Center, Pittsburgh, PA; ²Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Transplant Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Background: To study the impact on renal function and histological changes in patients(pts) with acute clinical rejection(ACR) and subclinical rejection(SCR) from 3 to 12 month(m)…
2015 American Transplant Congress
Left Ventricular Assist Device–Associated Allosensitization — Clinical Implications
B.-S. Ko, C. Willis, S. Drakos, D. Hurst, A. Kfoury, G. Snow, J. Delgado, E. Hammond, C. Selzman, R. Alharethi, S. McKellar, J. Nativi-Nicolau, E. Gilbert, P. Revelo, D. Miller, B. Reid, J. Fang, D. Eckles, J. Stehlik.
U.T.A.H. Cardiac Transplant Program, Salt Lake City, UT.
Purpose: Allosensitization has been recognized as a prognostic marker of worse outcome after transplant. It is unclear, however, whether sensitization events that take place shortly…
2015 American Transplant Congress
Elevated ST2 Levels Are Associated With Increased Risk of Antibody Mediated Rejection in Heart Transplant Recipients
A. Grupper,¹ S. Kushwaha,¹ O. Abou Ezzeddine,¹ J. Geske,² W. Kremers,² B. Edwards,¹ N. Pereira.¹
¹Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN; ²Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
Objective: Serum ST2, a member of the interleukin (IL) 1 receptor family, is a novel biomarker that reflects cardiac remodeling and fibrosis and is associated…
2015 American Transplant Congress
Propensity Score-Weighted Analysis of Induction Therapies in Live Donor Kidney Transplantation in Modern Immunosuppression Era
B. Tanriover,¹ S. Zhang,² M. MacConmara.³
¹Medicine, UTSW, Dallas, TX; ²Clinical Sciences, UTSW, Dallas, TX; ³Surgery, UTSW, Dallas, TX.
Background: Induction therapy with interleukin-2 receptor antagonist (IL2-RA) is recommended as a first line agent in living donor renal transplantation (LRT). However, use of IL2-RA…
2015 American Transplant Congress
Sevoflurane Based Anesthesia in Recipients Reduces 2 Year Acute Rejection in Living Donor Kidney Transplantation. Results from the VAPOR-Trial
G. Nieuwenhuijs-Moeke,¹ V. Nieuwenhuijs,² M. Seelen,³ R. Ploeg,² H. Leuvenink,² M. Struys.¹
¹Anesthesiology, University Medical Center, Groningen, Netherlands; ²Surgery, University Medical Center, Groningen, Netherlands; ³Nephrology, University Medical Center, Groningen, Netherlands.
IntroductionVolatile anesthetic agents like sevoflurane may protect against the ischemia and reperfusion injury (IRI) that is inevitable part of organ donation and transplantation. It is…
2015 American Transplant Congress
Delayed Graft Function (DGF) in Kidney Transplant Recipients (KTRs) Is Associated With Early Allograft Inflammation and Progressive Fibrosis Within 3 Months
A. Cherukuri, R. Mehta, P. Sood, S. Chen, G. Mour, A. Tevar, P. Randhava, S. Hariharan.
University of Pittsburgh, Pittsburgh.
DGF had been shown to be deleterious to KTR outcomes. Analysis of histological progression in KTRs with DGF was previously not attempted. In this prospective…
2015 American Transplant Congress
Impact of HLA Antibody Monitoring After Kidney Transplantation
S. Rao,¹ M. Ghanta,¹ H. Parekh,² A. Gillespie,¹ I. Lee,¹ S. Geier,² K. Lau,³ S. Karhadkar,³ A. Di Carlo,³ S. Constantinescu.¹
¹Nephrology, Temple Univesity School of Medicine, Philadelphia, PA; ²Pathology, Temple Univesity School of Medicine, Philadelphia, PA; ³Surgery, Temple Univesity School of Medicine, Philadelphia, PA.
The impact of donor specific antibodies (DSA) and optimal therapeutic intervention for DSA in kidney transplant (KT) recipients has been reported with variable results. We…
2015 American Transplant Congress
The Effect of Preformed and De Novo Donor-Specific Antibodies (DSA) in Acute Rejection (AR) After Liver Transplantation (LTX)
M. Koch,¹ M. Runnebaum,¹ M. Goebel,² H. Thude,¹ M. Sterneck,¹ M. Marget,² B. Nashan.¹
¹Hepatobiliary Surgery and Transplantation, University Medical Centre, Hamburg, Germany; ²HLA-Laboratory, University Medical Centre, Hamburg, Germany.
BACKGROUND: The role of preformed and den novo formed DSA in LTX is not fully revealed. The aim of our study was to determine if…