2016 American Transplant Congress
Proteoforms: Novel Biomarkers for Acute Rejection in Liver Transplant Recipients.
1Northwestern, Chicago; 2UPMC, Pittsburgh.
Background: Biomarker profiles diagnostic of acute rejection (AR) in liver transplant (LT) recipients could enhance the diagnosis and management of recipients. Our aim was to…2016 American Transplant Congress
Effect of Complement Inhibition Therapy (Eculizumab) in Patients with C1q-Binding Donor-Specific Anti-HLA Antibodies: A Molecular Appraisal.
Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft outcome. We investigated the effect of terminal complement inhibition (Eculizumab) in a cohort of…2016 American Transplant Congress
Detecting Renal Allograft Inflammation Using Quantitative Urine Metabolomics and CXCL10.
Background. We studied urine metabolomics (UM) alone or combined with urine CXCL10 to non-invasively detect cellular infiltrates in renal allograft biopsies.Methods. Urines (n=137) were obtained…2016 American Transplant Congress
Bortezomib Impacts Tenascin mRNA in PBMNCs.
Medical University of South Carolina, Charleston.
Tenascin (TNC) is a gene thought to play a role in the binding of receptors and syndecan binding. Syndecans are signal transmembrane proteins that act…2016 American Transplant Congress
Clinical Impact of Pre-Transplant Serum 25-Hydroxyvitamin D Levels on the Post-Transplant Immunologic and Non-Immunologic Outcomes in Kidney Transplant Recipients.
Background: The aim of this study is to investigate the clinical significance of pre-transplant serum 25-hydroxyvitamin D (25(OH)D) levels in regard to post-transplant clinical outcome…2016 American Transplant Congress
Impact of Preformed Anti-HLA Antibodies in the Outcomes of Kidney Transplantation.
Background:Anti-HLA antibodies are risk factors for acute and chronic rejection and allograft loss. Its detection represents a major advance and is widely used in organ…2016 American Transplant Congress
Anti-HLA Antibody Composition and Outcomes in Pediatric Heart Transplant Recipients with a Positive Cross-Match.
Purpose: Utilization of positive (+) cross-match (XM) hearts is tempting when shortages of pediatric donor hearts exist, especially for patients with high pre-transplant panel reactive…2016 American Transplant Congress
Risk of Acute Rejection Among ABO Incompatible Living Donor Kidney Recipients.
School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Background: ABO incompatible (ABOi) live donor kidney transplantation (LDKT) holds the potential for increased access to transplantation for ESRD patients. Concerns remain related to the…2016 American Transplant Congress
Antithymocyte (ATG) Dose Density in Renal Transplant Recipients (RTR) with Early Graft Dysfunction (EGD).
Houston Methodist Hospital, Houston, TX.
The cumulative amount of ATG for induction may be given as consecutive (cDD) or intermittent day dosages (iDD). iDD allows for leukocyte or platelet recovery…2016 American Transplant Congress
Diffuse Extent of Peritubular Capillaritis in Late Antibody Mediated Rejection Is Associated with More Severe Chronic Allograft Damage.
Peritubular capillaritis (ptc) is a widely accepted histologic criterion of antibody-mediated rejection (ABMR), and while the ptc score is incorporated in current diagnostic recommendations, the…
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