Articles tagged "Rejection"

2016 American Transplant Congress
Allo-Specific Memory B Cell Recall Responses Are Dependent on B Cell Autophagy.
J. Leventhal,¹ M. Fribourg,² J. Ni,¹ P. Heeger.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; ²Neurology, Icahn School of Medicine at Mount Sinai, NY, NY.
B cells, and in particular, memory B cells (Bmem) are sources of donor specific antibodies (DSA) that cause allograft injury. Understanding requirements for Bmem function/survival…
2016 American Transplant Congress
Tailored Rabbit Anti-Thymocyte Globulin Induction (rATG) Dosing for Kidney Transplantation.
N. Singh,^1,2 A. Rossi,¹ M. Savic,¹ R. Rubocki,¹ M. Parker,¹ J. Vella.¹
¹MMC, Portland, ME; ²MGMC, Augusta, ME.
Purpose: Although rATG is the most commonly used induction immunotherapy for kidney transplantation (KT), optimal dosing remains unknown. In order to minimize adverse effects and…
2016 American Transplant Congress
A Molecular Biopsy Test for Probability of Non-Adherence.
P. Halloran,^1,3 G. Einecke,² J. Reeve.¹
¹ATAGC, Edmonton, AB, Canada; ²Hannover Medical School, Hannover, Germany; ³Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…
2016 American Transplant Congress
Immunogenic HLA-DR Eplet Mismatches as Predictors of Transplant Glomerulopathy.
D. Blum,¹ K. Tinckam,² M. Marrari,³ J. Kim,² R. Sapir-Pichhadze.¹
¹McGill University, Montreal, Canada; ²University Health Network, Toronto, Canada; ³University of Pittsburgh Medical Center, Pittsburgh.
BackgroundThe number of HLA-DR eplet mismatches (eplet load) is a risk factor for the development of anti-HLA antibodies and transplant glomerulopathy (TG). In the case…
2016 American Transplant Congress
Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.
A. Cherukuri, R. Mehta, S. Ogunde, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh.
In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…
2016 American Transplant Congress
Skin as a Harbinger of Rejection of Underlying Structures in Vascularized Composite Allografts: Concordance or Discordance?
L. Cendales,¹ M. Levine,² S. Bartlett,³ J. Cheeseman,¹ C. Drachenberg,³ W. Hancock,⁴ M. Joshi,¹ A. Kirk,¹ F. Leoopardi,¹ S. Levin,² M. Uluer,³ A. Selim,⁵ M. Song,¹ W. Twaddell,³ L. Wang,⁴ Z. Wang,² R. Barth.³
¹Surgery, Duke University, Durham, NC; ²University of Pennsylvania, Philadelphia, PA; ³University of Maryland School of Medicine, Baltimore, MD; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ⁵Pathology, Duke University, Durham, NC.
Vascularized composite allografts (VCA) are composed of multiple tissue types. It has not been determined as to whether there is an immune hierarchy or differential…
2016 American Transplant Congress
The Impact of Treating Borderline Cellular Rejections.
R. Mustafa,¹ Y. Al Azzi,¹ J. Crew,¹ G. Dube,¹ H. Morris,¹ M. Chiles,¹ J. Chang,¹ H. Fernandez,¹ D. Cohen,¹ I. Batal,² E. Campenot,² S. Mohan.¹
¹Nephrology, Columbia University Medical Center, New York, NY; ²Pathology, Columbia University Medical Center, New York, NY.
Introduction: Histological findings that meet the criteria for Borderline rejection (BR) as defined by the Banff Classification are frequently seen. The clinical significance of a…
2016 American Transplant Congress
Profiling of T Cell Subsets in a Primate Cardiac Transplant Model.
N. O'Neill, T. Zhang, G. Braileanu, W. Sun, X. Cheng, C. Evans, R. Pierson, A. Azimzadeh.
Surgery, University of Maryland, Baltimore, MD.
Purpose: Costimulation blockade prolongs graft survival but does not induce tolerance in primates, and mechanisms of rejection are incompletely understood. Here we evaluate changes in…
2016 American Transplant Congress
Higher Pre-Transplant HDL Levels Are Associated with Decreased Acute Rejection Following Kidney Transplant.
J. Hagopian,¹ D. Brennan,² K. Lentine,³ T. Horwedel.¹
¹Barnes Jewish Hospital, St. Louis; ²Washington University, St. Louis; ³Saint Louis University Center for Transplant Research, St. Louis.
Purpose: Dyslipidemia is a common comorbidity in patients on the transplant waitlist and post-transplant, and hyperlipidemia has been associated with more robust immune response, possibly…
2016 American Transplant Congress
Antibody-Mediated Rejection Can Be Assessed by Histology When DSA Is Unknown or Negative.
J. Reeve,¹ P. Halloran.²
¹Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ²Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Diagnosis of antibody-mediated rejection (ABMR) in kidney transplants currently requires the presence of donor-specific antibody (DSA) and histologic lesions above somewhat arbitrary cutoffs. DSA is…