Articles tagged "Rejection"

2016 American Transplant Congress
Eculizumab for Chronic Antibody-Mediated Injury in Kidney Transplant Recipients: A Randomized-Controlled Trial.
S. Kulkarni,¹ N. Kirkiles-Smith,² Y. Deng,³ R. Formica,⁴ M. Gilbert,⁵ V. Broeckner,⁶ L. Bow,¹ J. Pober.²
¹Surgery, Yale University, New Haven, CT; ²Immunobiology, Yale University, New Haven, CT; ³Yale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT; ⁴Medicine, Yale University, New Haven, CT; ⁵Pathology, Yale University, New Haven, CT; ⁶Histopathology, Univeristy of Cambridge, Cambridge, United Kingdom.
Purpose: We hypothesize that de novo donor specific antibody (DSA) in kidney transplant patients cause endothelial cell injury that is dependent on complement and treatment…
2016 American Transplant Congress
Outcome of the Various Pathology Grades of Antibody-Mediated Rejection After Heart Transplantation.
J. Patel, M. Kittleson, D. Chang, T. Aintablian, L. Czer, A. Trento, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: The pathology scale for antibody-mediated rejection (AMR) was approved by the board of directors in 2013. The ISHLT AMR grading scale consists of pAMR…
2016 American Transplant Congress
Prospective Single Antigen Bead Epitope-Based Clustering for Early Detection of Antibody Mediated Rejection.
A. Lichvar, S. Tremblay, P. Brailey, A. Girnita, R. Alloway, E. Woodle.
U of Cincinnati, Cincinnati.
Purpose:Epitope-based groups of HLA single antigen beads (SAB) often demonstrate clustering in patients with donor specific antibodies (DSA). Coordinated Mean Florescent Intensity (MFI) increases of…
2016 American Transplant Congress
Quality Assessment and Process Improvement of Thymoglobulin Dosing.
H. Sarumi, L. Beck, C. Borscheid, B. Fast, S. Hogan, M. James, K. Vassar, D. Vock, T. Pruett.
University of Minnesota, Minneapolis.
Thymoglobulin (Thymo) induction is given to prevent early rejection while initiating maintenance immunosuppression. Modification of dosing is common for multiple reasons. Our center recently underwent…
2016 American Transplant Congress
Impact of C3d and C1q-Binding DSA Detected Long-Term After Kidney Transplantation.
M. Crespo,^1,2 D. Redondo,^1,2 C. Garcia,³ J. Gimeno,⁴ M. Perez,^1,2 M. Mir,¹ J. Hernandez,³ J. Yelamos,² A. Faura,^1,2 J. Pascual.^1,2
¹Nephrology and Transplant, Hospital del Mar, Barcelona, Spain; ²Medical Research Institute (IMIM), Hospital del Mar, Barcelona, Spain; ³Catalunya Reference Laboratory, Barcelona, Spain; ⁴Pathology, Hospital del Mar, Barcelona, Spain.
HLA DSA detected after kidney transplantation(KT) correlate with outcome, but not all are equal and produce the same functional consequences. Early complement-binding DSA were asssociated…
2016 American Transplant Congress
Increased Incidence of Clostridium difficile Infections with Proton Pump Inhibitor Use Post-Kidney Transplant.
M. Spinner,¹ K. Patel,¹ E. Neuner,¹ B. Stephany.²
¹Department of Pharmacy, Cleveland Clinic, Cleveland, OH; ²Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH.
Clostridium difficile infection (CDI) is often encountered in the solid-organ transplant patient population. The incidence in kidney transplant recipients ranges between 3.5-16%. There are CDI…
2016 American Transplant Congress
Tool to Assess Risk of Non-Adherence in Renal Transplant Candidates.
T. Kaiser,¹ K. Daley,² L. Dick,² L. Deye,² N. Parrish,² J. Huff,² A. Govil,¹ B. Abu Jawdeh,¹ G. Mogilishetty,¹ R. Alloway,¹ E. Woodle.¹
¹Medicine, University of Cincinnati, Cincinnati; ²Transplant, University of Cincinnati Medical Center, Cincinnati, OH.
Nonadherence (NA) is likely the primary driver of late graft loss and was found to occur in 59% of renal transplant (RTx) patients at our…
2016 American Transplant Congress
Designing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Longterm Heart Allograft Acceptance While Inducing Immune Cell Exhaustion, Treg Induction and Memory Cell Suppression.
E. Sula Karreci,¹ A. Mihali,¹ M. Uehara,¹ A. Kurdi,¹ L. Riella,¹ R. Abdi,¹ H. Fan,² P. Singh,² C. Nathan,² G. Lin,² J. Azzi.¹
¹Transplantation Research Center, Harvard Medical School, Boston, MA; ²Department of Microbiology and Immunology, Weill Cornell Medicine, New York City, NY.
The constitutive Proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. However, immunoproteasomes (IP or i-20S) are primarily expressed…
2016 American Transplant Congress
Mothers Are Often Sensitized and Sensitive: Antibody Mediated Rejection in Child to Mother Living Donor Liver Transplantation.
B. Movahedi,¹ N. Yu,² P. Martins,¹ A. Ahearn,¹ J. Stoff,¹ A. Bozorgzadeh.¹
¹Division of Organ Transplantation, UMass Memorial Medical Center, Worcester, MA; ²Clinical Pathology, Histocompatibility Laboratory, UMass Memorial Medical Center, Worcester, MA.
Background: Partial graft is especially more vulnerable to deleterious effects of donor specific HLA antibodies (DSA). Living liver donors and recipients are often family members.…
2016 American Transplant Congress
An Improved Method for the Evaluation of Microvascular Inflammation in Renal Allograft Biopsies.
M. Rooney,¹ Z. Ping,² D. Samarapungavan,³ R. Hennigar.⁴
¹Incyte Diagnostics, Spokane Valley, WA; ²Pathology, Beaumont Hospitals, Royal Oak, MI; ³Nephrology, Beaumont Hospitals, Royal Oak, MI; ⁴Nephropathology Associates, Little Rock, AR.
Background: Microvascular inflammation (MVI), assessed as glomerulitis (g) + peritubular capillaritis (ptc), is associated with T cell mediated (CMR) and antibody mediated (AMR) allograft rejection.…