Articles tagged "Rejection"

2016 American Transplant Congress
Systematic Pathological Component Scores for Skin-Containing Vascularized Composite Allografts.
I. Rosales,¹ M. DeFazio,² R. Foreman,¹ D. Sachs,² C. Cetrulo,² D. Leonard,^2,3 R. Colvin.¹
¹Pathology, Massachusetts General Hospital, Boston; ²Transplantation Biology Research Center, Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston; ³Plastic and Reconstructive Surgery, Countess of Chester Hospital, Chester, United Kingdom.
Successful application of skin-containing vascularized composite allografts (VCA) depends on accurate assessment of the graft status typically based on skin biopsies. A working classification (Banff…
2016 American Transplant Congress
Protective Impact of the Kidney in SPK Transplants – Mechanisms for Improved Outcomes Compared with Solitary Transplants.
E. Finger, T. Dunn, A. Kukla, V. Kirchner, R. Kandaswamy.
Surgery, University of Minnesota, Minneapolis, MN.
Purpose: Outcomes for SPK txps are superior to solitary pancreas txps. The basis for this difference is unknown. We sought to identify the biologic mechanism…
2016 American Transplant Congress
Induction Therapy with Depleting Antibodies in Low Immunological Risk Renal Transplant Patients Treated with a Steroid Free Regimen – Comparison of Alemtuzumab vs. Antithymocyte Globulin.
N. Bossini,¹ S. Sandrini,¹ R. Tardanico,² F. Valerio,¹ G. Setti,¹ C. Salviani,¹ S. Possenti,¹ P. Foini,¹ E. Marta,¹ G. Cancarini.¹
¹Division and Chair of Nephrology, A.O "Spedali Civili" and University, Brescia, Italy; ²Division and Chair of II Laboratory of Pathology, A.O "Spedali Civili" and University, Brescia, Italy.
Induction therapy with depleting antibodies reduces rejection rate and potentially improves efficacy of steroid free regimens after renal transplantation.This prospective, single-centre, cohort study evaluated cumulative…
2016 American Transplant Congress
Urine Cell-Free Supernatant Metabolites Diagnostic of Antibody Mediated Rejection in Kidney Allografts.
M. Alkadi,¹ J. Lee,¹ D. Dadhania,¹ T. Muthukumar,¹ C. Snopkowski,¹ C. Li,¹ S. Salvatore,¹ S. Seshan,¹ K. Suhre,² M. Suthanthiran.¹
¹Weill Cornell Medicine, NY; ²Weill Cornell Medical College-Qatar, Doha, Qatar.
Introduction:Urine cell-free supernatant metabolite profiles provide a unique opportunity to interrogate intra-graft processes and have distinguished acute cellular rejection from no rejection in the Clinical…
2016 American Transplant Congress
DSA After Transplant Increases Risk of Renal Allograft Failure Independent of Concurrent Biopsy Results: The DEKAF Study Data.
J. Cecka,¹ J. Grande,² F. Cosio,² R. Leduc,³ The DeKAF Study Group.
¹UCLA Immunogenetics Center Department of Pathology, University of California-Los Angeles, Los Angeles, CA; ²Department of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; ³Department of Biostatistiscs, University of Minnesota School of Public Health, Minneapolis, MN.
Donor-specific HLA antibodies (DSA) are a major cause of renal allograft dysfunction and loss following transplant. The presence of DSA, with or without C4d deposition,…
2016 American Transplant Congress
Mining the Human Proteome for Monitoring Renal Transplant Injury.
T. Sigdel,¹ Y. Gao,² J. He,² A. Wang,¹ C. Nicora,² D. Smith,² W. Qian,² D. Camp,² M. Sarwal.¹
¹Surgery, University of California-San Francisco, San Francisco; ²Pacific Northwest National Laboratory, Richland.
The human urinary proteome reflects systemic and inherent renal injury perturbations and can be harnessed to define biomarkers for different kidney transplant injury states. Through…
2016 American Transplant Congress
Radiosensitive Cell Population Prolongs Graft Survival of Vascularized Composite Allografts in Non-Human Primates.
M. Uluer, J. Woodall, W. Hassanein, U. Drhu, B. Bojovic, A. Nam, S. Bartlett, R. Barth.
University of Maryland School of Medicine, Baltimore, MD.
Background: Vascularized composite allografts (VCA) containing vascularized bone marrow (VBM) prolong graft survival. To help elucidate this protective immunomodulatory effect, we irradiated donor facial VCA…
2016 American Transplant Congress
Acute Allograft Glomerulopathy: A Distinct Form of Cellular Rejection.
O. AL-Badri, M. Alexander, F. Cosio, L. Cornell.
Mayo Clinic, Rochester, MN.
Background: Acute allograft glomerulopathy (AAG) is an unusual glomerular lesion of allografts with endocapillary hypercellularity, markedly enlarged endothelial cells occluding the capillary lumen, and absence…
2016 American Transplant Congress
Distinct Effects of Chronic Hyperglycemia on Cellular and Humoral Alloresponses In Vivo.
N. Bishop,¹ K. Beard,² R. Gill.²
¹Immunology and Microbiology, University of Colorado Denver, Aurora, CO; ²Surgery, University of Colorado Denver, Aurora, CO; ³Surgery, University of Colorado Denver, Aurora, CO.
Background: Diabetes constitutes a significant problem in the transplant recipient. Diabetes is associated with impaired immunity to pathogens but its effect on alloimmunity remains ambiguous.…
2016 American Transplant Congress
High KDPI Is a Predictor of Acute Rejection in Delayed Graft Function.
B. Muth,¹ J. Turk,¹ S. Parajuli,¹ D. Mandelbrot,¹ M. Mohamed,¹ R. Redfield,² D. Kaufman,² A. Djamali.^1,2
¹Department of Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI.
The kidney donor profile index (KDPI) is a prognostic measure for graft function and survival. It is unclear whether it predicts acute rejection in patients…