ATC Abstracts

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Articles tagged "Rejection"

  • 2017 American Transplant Congress

    Banff 2013 Classification of Renal Allograft Pathology Is Superior to Banff 2007 in Detecting and Managing Milder and Earlier Cases of Antibody-Mediated Rejection.

    J. Hassler,1 V. Ariyamuthu,2 A. Hendricks,1 B. Tanriover,2 J. Torrealba.1

    1Pathology, University of Texas Southwestern Medical Center, Dallas, TX; 2Medicine, Nephrology, University of Texas Southwestern Medical Center, Dallas, TX

    The 2013 Banff meeting updated the requirements for the diagnosis of acute/active antibody-mediated rejection (AAMR) in kidney allografts. There has been speculation that the changes…
  • 2017 American Transplant Congress

    Emerging Variables Which May Enhance Care of HIV Positive Renal Transplant Recipients.

    D. Leonard, M. Prendergast.

    Transplantation, Mayo Clinic, Jacksonville, FL

    Purpose: Single center experience of kidney and pancreas transplantation in the HIV positive populationMethods: Retrospective data and outcomes analysis of HIV positive kidney and pancreas…
  • 2017 American Transplant Congress

    Microvascular Inflammation at 4 Months Posttransplant Is Associated with Transplant Glomerulopathy at One and Two Years Independent of Rejection and Donor Specific Antibodies.

    H. Khamash, G. Mour, L. Archambault, M. Buras, H. Kosiorek, M. Pando, K. Reddy, H. Chakkera, J. Huskey, S. Nair, A. Jaramillo, M. Smith, B. Kaplan, R. Heilman.

    Mayo Clinic Arizona, Phoenix

    Aim: Study factors that are associated with transplant glomerulopathy (TG) in flowcytometric crossmatch negative kidney transplant recipients with no desensitization.Methods:Single center retrospective analysis of characteristics…
  • 2017 American Transplant Congress

    The Value of Protocol Biopsy at Third Month After Kidney Transplant: A Single-Center Cohort Analysis.

    R. Rosado-Canto, C. Barrientos-Aguilar, I. Parra-Avila, L. Marino, M. Arvizu-Hernandez, N. Uribe-Uribe, L. Morales-Buenrostro.

    Departament of Nephrology and Transplant, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico

    Introduction: In spite of publications reporting higher detection of subclinical rejection (SR) with protocol biopsies in kidney transplant (KT) recipients there is no recommendation with…
  • 2017 American Transplant Congress

    Three Induction Therapies on Patients with Delayed Graft Function After Kidney Transplantation, a Three-Year Outcome Analysis.

    A. Umber, M. Killackey, A. Paramesh, B. Alper, F. Teran, A. Baudy, Y. Liu, J. Buell, R. Zhang.

    Departments of Medicine and Surgery, Tulane University School of Medicine, New Orleans, LA

    We compare the 3-year outcomes of induction therapies with either methylprednisolone (group 1, n=58), basiliximab (group 2, n=56) or alemtuzumab (group 3, n=98) in primary…
  • 2017 American Transplant Congress

    Human Regulatory T Cells Undergo Self-Inflicted Damage via Granzyme Pathways Upon Activation.

    J. Assaker, E. Karreci, F. Dotiwala, S. Routray, A. Kurdi, A. Mihali, T. Borges, A. Chandraker, L. Riella, R. Abdi, J. Lieberman, J. Azzi.

    Transplantation Research Center, Harvard Medical School, Boston; Boston Children's Hospital, Harvard Medical School, Boston

    In this study, we investigated the mechanisms behind the activation induced cell death of human regulatory T cells (Tregs) that can explain their rapid loss…
  • 2017 American Transplant Congress

    Pre Transplant Donor Specific Antibodies and Clinical Outcomes in Kidney Transplant Recipient on Steroid Free Maintenance Immunosupression Regimen.

    O. Adebiyi,1 A. Sharfuddin,2 M. Yaqub,1 S. Hussain,1 D. Mishler,1 A. Sharfuddin,1 W. Goggins,1 T. Taber.1

    1Renal Transplant, Indiana University School of Medicine, Indianapolis, IN; 2Internal Medicine, Baqai University Hospital, Karachi, Pakistan

    Background: The clinical relevance of pre transplant donor specific antibodies has been reported in few clinical studies with respect to its effect on the risk…
  • 2017 American Transplant Congress

    Urinary Proteomics to Diagnose Chronic-Antibody-Mediated Rejection in Pediatric Kidney Transplantation.

    N. Kanzelmeyer, P. Zürbig, H. Mischack, K. Heindl Ruszai, T. Seemann, M. Hansen, M. Henn, A. Fichtner, B. Toenshoff, A. Melk, L. Pape.

    Pediatric Nephrology, Hannover Medical School, Hannover, Germany; Mosaiques Diagnostics, Hannover, Germany; Pediatric Nephrology, University Hospital of Vienna, Vienna, Austria; Pediatric Nephrology, University Hospital of Prague, Prague, Czech Republic; KfH Center for Pediatric Nephrology, Leipzig, Germany; Pediatrics I, University Hospital of Heidleberg, Heidleberg, Germany

    Chronic antibody-mediated rejection (cAMR) is the main cause of long-term graft loss and presents a diagnostic challenge in renal transplantation medicine. Late-stage diagnosis is made…
  • 2017 American Transplant Congress

    Pre-Transplant Evaluation of KSORTSM to Assess Risk for Rejection in Highly Sensitized Patients.

    S. Nandoe,1 S. Roedder,3 S. Hsieh,1 T. Sigdel,1 P. Lindner,4 J. Ekberg,4 J. Alberu,5 F. Vincenti,1 M. Sarwal.1

    1UCSF, San Francisco, CA; 2Immucor, Norcross, GA; 3Gothenburg University, Gothenburg, Sweden; 4Salvador Zubiran, Mexico City, Mexico

    Study purpose: To investigate the kSORTSM molecular expression assay for immune risk assessment in renal transplant (tx) recipients prior to tx for correlation of pre-tx…
  • 2017 American Transplant Congress

    A Molecular Signature Characterized by Dominance of Negative Regulation over Cytotoxic Effectors in Tolerant Kidney Allograft Recipients.

    J. Lee,1 J. Leventhal,2 C. Li,1 A. Katapodis,3 S. Ildstad,4 M. Suthanthiran.1

    1Medicine, Weill Cornell, NY, NY; 2Surgery, Northwestern Medicine, Chicago, IL; 3Novartis, Basel, Switzerland; 4Regenerex, Louisville, KY

    Introduction. Development of tolerance biomarkers is important for interrogating the in-vivo immune status of patients entered in clinical trials of tolerance.Methods. To determine the feasibility…
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