Articles tagged "Rejection"

2017 American Transplant Congress
The IL6/Th17 Pathway May Play Different Roles in Cell-Mediated and Antibody-Mediated Alloimmune Injury in Renal Allografts.
D. Dobi,¹ Q. Tang,² S. Chandran,³ F. Vincenti,³ Z. Laszik.¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, Division of Transplant Surgery, University of California, San Francisco, San Francisco, CA; ³Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, CA
Purpose. IL6 has been shown to contribute to shifting the balance between tolerogenic regulatory T cells and proinflammatory Th17 cells towards the latter. Our study…
2017 American Transplant Congress
Predictive Value of Renal Poly (ADP-Ribose) Polymerase (PARP) Expression Both in Inflammation and Interstitial Fibrosis Processes in Recipients with Antibody-Mediated Rejection.
B. Ozdemir,¹ F. Ozdemir,² E. Baskin,² M. Haberal.³
¹Pathology, Baskent University, Ankara, Turkey; ²Nephrology, Baskent University, Ankara, Turkey; ³Transplant Surgery, Baskent University, Ankara, Turkey
The activation of PARP is well considered to play an augmenting role in inflammation. However, its role in the development of fibrosis is not well…
2017 American Transplant Congress
Long-Term Outcome of Antibody-Mediated Rejection Due to Pre-Existing vs. De Novo DSA in Kidney Allograft Recipients.
O. Aubert,¹ C. Lefaucheur,¹ S. Higgins,¹ L. Hidalgo,² J. Duong Van Huyen,¹ D. Viglietti,¹ X. Jouven,¹ D. Glotz,¹ P. Halloran,² A. Loupy.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²ATAGC, Edmonton, Canada
BackgroundAntibody-mediated rejection (ABMR) can occur in patients with pre-existing anti-HLA donor-specific antibodies (DSA) or in patients who develop de novo DSA. However, how these processes…
2017 American Transplant Congress
A Search for a Biomarker Which Predicts Belatacept-Resistant Rejection.
G. de Graav,¹ C. Baan,¹ M. Clahsen-van Groningen,² R. Kraaijeveld,¹ M. Dieterich,¹ W. Verschoor,¹ D. Roelen,³ M. Cadogan,¹ J. van de Wetering,¹ J. van Rosmalen,⁴ W. Weimar,¹ D. Hesselink.¹
¹Internal Medicine, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands; ²Pathology, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands; ³Immunohematology and Blood Transfusion, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands; ⁴Biostatistics, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands
Belatacept, an inhibitor of the CD28-CD80/86 costimulatory pathway, has been associated with a higher acute rejection risk than ciclosporin. We sought to identify a biomarker…
2017 American Transplant Congress
A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Quantifies and Differentiates Kidney Transplant Injury.
T. Sigdel,¹ J. Yang,¹ O. Bestard,² S.-C. Hsieh,¹ S. Roedder,² I. Damm,¹ J. Liberto,¹ S. Nandoe,¹ M. Sarwal.¹
¹University of California San Francisco, San Francisco; ²Immucor Inc, Atlanta
We sought to investigate the use of the common rejection module (CRM) genes in the discrimination of AR, BKVN, and stable transplant phenotypes in urine…
2017 American Transplant Congress
Gene Expression During Development of Chronic Antibody-Mediated Rejection in Renal Allografts from Non-Human Primates: Validation of Markers Used in Humans and Sequential Changes in Protocol Biopsies.
B. Adam,¹ R. Smith,² M. Matsunami,² I. Rosales,² B. Afzali,¹ T. Oura,² A. Cosimi,² T. Kawai,² R. Colvin,² M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Harvard Medical School and Massachusetts General Hospital, Boston
Background: RNA transcript measurement is a promising adjunct for the diagnosis and classification of antibody-mediated rejection (ABMR), however most technologies require specially processed biopsy samples.…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Predicts Biopsy-Proven Acute Cellular Rejection in Pediatric Kidney Transplant Recipients.
D. Stoltz,¹ A. Brubaker,¹ M. Grskovic,² R. Woodward,² A. Gallo.¹
¹Surgery, Stanford University, Palo Alto, CA; ²CareDx, Brisbane, CA
Introduction: Surveillance of allograft health is a critical component of post-kidney transplant care. Invasive protocol biopsies are associated with secondary complications and often provide results…
2017 American Transplant Congress
Circulating Donor-Specific Memory B Cells (mBc) Discriminates Kidney Transplant Patients with Histological Lesions of ABMR in Absence of Circulating DSA.
S. Luque,² M. Lúcia,⁴ M. Jarque,² E. Crespo,² E. Melilli,¹ J. Martorell,³ J. Cruzado,^1,2 J. Torras,^1,2 J. Grinyó,^1,2 O. Bestard.^1,2
¹Kidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; ²Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; ³Immunogenetics Laboratory, Hospital Clínic, Barcelona, Catalunya, Spain; ⁴Transplant Immunology, School of Medicine, Stanford
Chronic (c)ABMR is a main cause of immune-mediated kidney allograft loss. For its diagnosis, specific histological lesions together with presence of circulating donor-specific alloantibodies (DSA)…
2017 American Transplant Congress
Kidney-Specific Immunosuppression without Adverse Systemic Effects.
D. Kentrup,¹ K. Schuette-Nuetgen,¹ H. Pawelski,¹ H. Pavenstädt,¹ S. Hermann,² M. Schaefers,² G. Larbig,³ A. Kuebelbeck,³ S. Reuter.¹
¹Department of Medicine D, University Hospital Muenster, Muenster, Germany; ²European Institute for Molecular Imaging - EIMI, University Hospital Muenster, Muenster, Germany; ³Merck KGaA, Darmstadt, Germany
Purpose: Immunosuppressive therapy is often accompanied by severe adverse effects. To overcome this, the aim of this study was the evaluation of a kidney-specific drug…
2017 American Transplant Congress
HLA Class II Molecules Partner with TLR4 to Stimulate Endothelial Cell Activation and Proliferation.
Y.-P. Jin, E. Reed.
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
Background: Transplant recipients developing donor specific HLA antibodies (DSA) are at a higher risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the…