Articles tagged "Rejection"

2017 American Transplant Congress
Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.
J. Bromberg,¹ D. Brennan,² E. Poggio,³ D. Hiller,⁴ R. Woodward,⁴ J. Yee,⁴ J. Sninsky,⁴ R. Bloom.⁵
¹University of Maryland, Baltimiore, MD; ²Washington University, St. Louis, MO; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…
2017 American Transplant Congress
Ornithine Transcarbamylase Deficiency (OTC) in the Donor Liver, the Importance of Ascertaining the Cause of Death in the Brain Dead Donor.
M. George,¹ G. Thomas,¹ A. Shun,¹ M. Stormon.²
¹Paediatric Surgery and Transplant Surgery, Children's Hospital at Westmead, Sydney, NSW, Australia; ²Paediatric Gastroenterology, Children's Hospital at Westmead, Sydney, NSW, Australia
The importance of ascertaining the cause of brain death in the donor is vital . We present a case of cadaveric liver donation (seg 2…
2017 American Transplant Congress
Do Perioperative Blood Transfusions Influence Kidney Transplant Outcomes in the Modern Era?
J. Lineen, J. Trac, Y. Li, O. Famure, J. Kim.
Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada
Background: Blood transfusions are a well-established risk factor for human leukocyte antigen sensitization in kidney transplant candidates. To date, relatively few studies have explored the…
2017 American Transplant Congress
Rejection of Human Kidney Allografts According to BANFF Classification Is Associated with a Chemokine-Enriched Protein Microenvironment in Biopsy Tssue.
C. Falk,¹ K. Daemen,¹ J. Keil,¹ F. Lehner,² H. Haller,³ J. Schmitz,⁴ J.-H. Bräsen,⁴ C. Blume.⁵
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Abdominal, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany; ³Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; ⁴Institute of Pathology, Hannover Medical School, Hannover, Germany; ⁵Institute for Technical Chemistry, Leibniz University, Hannover, Germany
Background: Expression profiling efforts of biopsy tissue after kidney transplantation indicate that rejection can be defined by distinct signatures. Based on pathological evaluation (BANFF) as…
2017 American Transplant Congress
Prediction of Renal Allograft Acute Rejection Using a Novel Non-Invasive Model Based on Acoustic Radiation Force Impulse.
C. Yang,¹ Y. Jin,² S. Wu,³ T. Zhu,¹ W. He.²
¹Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ²Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China; ³Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China
Point shear wave elastography (p-SWE) based on acoustic radiation force impulse (ARFI) is a novel technology to quantify tissue stiffness by measuring shear wave speed…
2017 American Transplant Congress
Adjunctive Thymoglobulin with Proteasome Inhibitor Based Treatment of Late Mixed Acute Rejection.
A. Lichvar,¹ A. Leino,¹ S. Tremblay,¹ A. Shields,² F. Paterno,¹ A. Govil,¹ M. Anand,¹ T. Diwan,¹ J. Kremer,² R. Alloway,¹ E. Woodle.¹
¹University of Cincinnati, Cincinnati; ²The Christ Hospital, Cincinnati
Proteasome inhibitor (PI) containing regimens treat mixed acute rejection (MAR) at least in part due to elimination of donor specific antibody (DSA) and via effects…
2017 American Transplant Congress
Long-Term Outcome of Antibody-Mediated Rejection Due to Pre-Existing vs. De Novo DSA in Kidney Allograft Recipients.
O. Aubert,¹ C. Lefaucheur,¹ S. Higgins,¹ L. Hidalgo,² J. Duong Van Huyen,¹ D. Viglietti,¹ X. Jouven,¹ D. Glotz,¹ P. Halloran,² A. Loupy.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²ATAGC, Edmonton, Canada
BackgroundAntibody-mediated rejection (ABMR) can occur in patients with pre-existing anti-HLA donor-specific antibodies (DSA) or in patients who develop de novo DSA. However, how these processes…
2017 American Transplant Congress
A Search for a Biomarker Which Predicts Belatacept-Resistant Rejection.
G. de Graav,¹ C. Baan,¹ M. Clahsen-van Groningen,² R. Kraaijeveld,¹ M. Dieterich,¹ W. Verschoor,¹ D. Roelen,³ M. Cadogan,¹ J. van de Wetering,¹ J. van Rosmalen,⁴ W. Weimar,¹ D. Hesselink.¹
¹Internal Medicine, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands; ²Pathology, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands; ³Immunohematology and Blood Transfusion, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands; ⁴Biostatistics, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands
Belatacept, an inhibitor of the CD28-CD80/86 costimulatory pathway, has been associated with a higher acute rejection risk than ciclosporin. We sought to identify a biomarker…
2017 American Transplant Congress
A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Quantifies and Differentiates Kidney Transplant Injury.
T. Sigdel,¹ J. Yang,¹ O. Bestard,² S.-C. Hsieh,¹ S. Roedder,² I. Damm,¹ J. Liberto,¹ S. Nandoe,¹ M. Sarwal.¹
¹University of California San Francisco, San Francisco; ²Immucor Inc, Atlanta
We sought to investigate the use of the common rejection module (CRM) genes in the discrimination of AR, BKVN, and stable transplant phenotypes in urine…
2017 American Transplant Congress
Gene Expression During Development of Chronic Antibody-Mediated Rejection in Renal Allografts from Non-Human Primates: Validation of Markers Used in Humans and Sequential Changes in Protocol Biopsies.
B. Adam,¹ R. Smith,² M. Matsunami,² I. Rosales,² B. Afzali,¹ T. Oura,² A. Cosimi,² T. Kawai,² R. Colvin,² M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Harvard Medical School and Massachusetts General Hospital, Boston
Background: RNA transcript measurement is a promising adjunct for the diagnosis and classification of antibody-mediated rejection (ABMR), however most technologies require specially processed biopsy samples.…