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Articles tagged "Rejection"

  • 2017 American Transplant Congress

    Predictive Value of Pre-Transplant Cross-Match Techniques on Living Donor Kidney Transplant Outcomes.

    M. Meneghini,1 E. Melilli,1 I. Revuelta,3 R. Rajalingam,2 E. Rigol,4 S. Chandran,2 F. Diekmann,3 F. Vincenti,2 J. Cruzado,1 J. Martorell,4 O. Bestard.1

    1Kidney Transplant Unit, Bellvitge University Hospital; IDIBELL, Barcelona, Spain; 2Kidney Transplant Unit, UCSF Medical Centre, SanFrancisco; 3Kidney Transplant Unit, Clinic University Hospital, Barcelona, Spain; 4Immunology Department, Clinic University Hospital, Barcelona, Spain

    Study aim: To investigate the impact of different cross-match techniques and their combination before living-donor kidney transplantation(LDKT) on main clinical outcomes.Methods: Retrospective study including 394…
  • 2017 American Transplant Congress

    Integrative Analysis of ExomeSeq and Gene Expression Data for Identification of Novel Variants Associated with Antibody-Mediated Rejection in Kidney Transplant.

    S. Pineda,1,2 T. Sigdel,2 A. Jackson,3 M. Sirota,1,2 M. Sarwal.2

    1Institute for Computational Health Science, University of California, San Francisco (UCSF), San Francisco, CA; 2Department of Surgery, University of California, San Francisco (UCSF), University of California, San Francisco (UCSF), CA; 3Department of Medicine, Johns Hopkins, Baltimore, MD

    Background: The objective of this work is to characterize the impact of the donor-recipient (D/R) HLA and non-HLA mismatches on the risk of antibody-mediated rejection…
  • 2017 American Transplant Congress

    Transcript Changes Associated with Graft Rejection Are Not Specific for Rejection Because They Are Shared with Tissue Responses to Wounding.

    P. Halloran, K. Famulski, INTERCOMEX Study Group.

    University of Alberta, Edmonton, Canada

    The diagnosis of rejection by histology is based on the presence of relatively non-specific lesions. This is because the histology lesions are actually non-specific, but…
  • 2017 American Transplant Congress

    Triptolide Alleviating Acute Antibody Mediated Rejection by Inhibition of B Cell Activation in Presensitized Recipients.

    D. Zhao,1 S. Li,1 T. Liao,1 Y. Wei,2 X. Hua,1 F. Han,1 Z. Luo,1 X. Liu,1 Q. Sun.

    1Kidney Transplantation, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; 2Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China

    Backgroud: Acute antibody mediated rejection (AMR), resistant to most anti-rejection therapy, is main cause for renal graft loss. Triptolide(TPL) had been reported as a promising…
  • 2017 American Transplant Congress

    HLA Mismatching Does Not Have an Impact on Graft or Patient Survival in Simultaneous Kidney-Pancreas Transplantation. A Single Institution Experience.

    I. Moinuddin, M. Yaqub, T. Taber, D. Mishler, M. Mujtaba, J. Powelson, O. Adebiyi, J. Fridell, A. Sharfuddin.

    Indiana University Health, Indianapolis

    Purpose: There is conflicting data on whether the level and type of HLA mismatching (MM) has an impact on pancreas, kidney, or patient survival in…
  • 2017 American Transplant Congress

    High Risk Renal Transplant Recipients on Steroid Free Immunosupression Regimen. Indiana University Experience.

    O. Adebiyi, S. Hussain, D. Mishler, W. Goggins, M. Yaqub, T. Taber, A. Sharfuddin.

    Renal Transplant, Indiana University School of Medicine, Indianapolis, IN

    Background : Immunologic risk often influence the choice immunosuppressive regimen used in renal transplant recipient. Patient with positive flow cytometry crossmatch (FCXM) or presence of…
  • 2017 American Transplant Congress

    Rabbit Anti-Human Thymocyte Immunoglobulin (rATG) for Rescue Treatment of Chronic Antibody-Mediated Rejection (cAMR) After Pediatric Kidney Transplantation.

    L. Pape, T. Ahlenstiel-Grunow, J. Drube, M. Kreuzer, C. Lerch, N. Kanzelmeyer, S. Wente, I. Hennies, Y. Cihan.

    Pediatric Nephrology, Hannover Medical School, Hannover, Germany

    Background. Chronic antibody-mediated rejection (cAMR) is the leading cause of long-term graft loss after kidney transplantation. Treatment guidelines include rituximab, immunoadsorption, immunoglobulins and/or bortezomib, but…
  • 2017 American Transplant Congress

    Predicting Immunologic Risk for Acute Rejection in Pediatric Liver Transplantation.

    S. Antala, L. Bow, R. Morotti, G. Gan, D. Yanhong, U. Ekong, S. Emre.

    Yale University, New Haven, CT

    Background: Studies in heart, lung, kidney, & liver transplantation (LT) indicate an increased negative impact of antibodies (Ab) to HLA on allograft outcome.Aim: To describe…
  • 2017 American Transplant Congress

    Anti-Angiotensin Type 1 Receptor Antibodies Associate with Rejection in Simultaneous Pancreas and Kidney Transplant and Pancreas Transplant Alone Recipients.

    A. Peng, D. Dafoe, J. Choi, A. Vo, X. Zhang, R. Najjar, E. Huang, S. Jordan.

    Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA

    Background: Anti-angiotensin type 1 receptor antibodies (AT1R Ab) have been found to have a strong association with antibody mediated rejection (Reinsmoen et al, Transpl 2010;…
  • 2017 American Transplant Congress

    Safety and Activity of Anti-C1s Humanized Monoclonal Antibody TNT009 in Late Antibody-Mediated Kidney Allograft Rejection – Results of a First-in-Human Phase 1 Trial.

    F. Eskandary,1 B. Jilma,2 J. Muehlbacher,3 M. Wahrmann,1 H. Regele,4 N. Kozakowski,4 S. Panicker,5 J. Reeve,6 P. Halloran,6 J. Gilbert,5 G. Bohmig.1

    1Department of Medicine III, Medical University Vienna, Vienna, Austria; 2Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria; 3Department of Surgery, Medical University Vienna, Vienna, Austria; 4Department of Clinical Pathology, Medical University Vienna, Vienna, Austria; 5True North Therapeutics Inc., San Frnacisco; 6Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada

    Study purpose:The classical pathway (CP) of complement may significantly contribute to antibody-mediated rejection (ABMR). Blockade of CP key component C1 may be a promising strategy…
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